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Protein

Mitochondrial uncoupling protein Bmcp

Gene

Bmcp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates metabolic homeostasis in response to nutritional cues and may therefore be involved in adaptation to dietary variations. May not function in creating mitochondrial proton leaks across the inner mitochondrial membrane (i.e. mitochondrial uncoupling).1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrial transport Source: GO_Central
  • regulation of metabolic process Source: FlyBase
  • sensory perception of sound Source: FlyBase

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DME-167826. The fatty acid cycling model.
R-DME-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein BmcpCurated
Alternative name(s):
Brain mitochondrial carrier protein 11 Publication
Short name:
Bmcp-11 Publication
Mitochondrial uncoupling protein 51 Publication
Gene namesi
Name:BmcpImported
Synonyms:Ucp51 Publication
ORF Names:CG7314Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036199. Bmcp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 27Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei72 – 90Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei112 – 131Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei171 – 190Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei278 – 297Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Reduced levels of total sugars (glucose and trehalose) in normal-fed flies and increased susceptibility to starvation. Life span is increased when fed a low-calorie diet and flies gain less weight when fed a high-calorie diet. Females lay a lower proportion of eggs, particularly under a restricted diet. Glycogen and triacylglyceride (TAG) levels are not affected in normal-fed flies. However, TAG levels decrease at a faster rate under starvation conditions. No increase in life span when fed a high-calorie diet or under starvation conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004387781 – 303Mitochondrial uncoupling protein BmcpAdd BLAST303

Expressioni

Tissue specificityi

Expression levels are higher in the head than the body.1 Publication

Developmental stagei

Expressed throughout development. Expression levels are very weak, but increase in the adult stages.1 Publication

Gene expression databases

BgeeiFBgn0036199.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0075846.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 97Solcar 1PROSITE-ProRule annotationAdd BLAST90
Repeati111 – 196Solcar 2PROSITE-ProRule annotationAdd BLAST86
Repeati203 – 303Solcar 3PROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
KOiK15106.
OMAiDMDQDLA.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ7K566.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q7K566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEVKDWRPF VYGGVASITA EFGTFPIDTT KTRLQIQGQK IDQSFSQLRY
60 70 80 90 100
RGMTDAFVKI SREEGLRALY SGIWPAVLRQ ATYGTIKFGT YYTLKKLANE
110 120 130 140 150
RGLLINEDGS ERVWSNILCA AAAGAISSAI ANPTDVLKVR MQVHGKGQHK
160 170 180 190 200
GLLGCFGEIY KYEGVRGLWR GVGPTAQRAV VIASVELPVY DFCKLQLMNA
210 220 230 240 250
FGDHVGNHFI SSFIASLGSA IASTPIDVIR TRLMNQRPVS ITMNGVVTAA
260 270 280 290 300
ATPKLYSGSL DCAVQTIRNE GLPALYKGFI PTWVRMGPWN IIFFITYEQL

KKY
Length:303
Mass (Da):33,493
Last modified:October 17, 2006 - v1
Checksum:iE52A93E2A2E5AC48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50019.1.
AE014296 Genomic DNA. Translation: AAN11881.1.
AY051433 mRNA. Translation: AAK92857.1.
RefSeqiNP_648501.1. NM_140244.5.
NP_729738.1. NM_168472.2.
UniGeneiDm.4611.

Genome annotation databases

EnsemblMetazoaiFBtr0076114; FBpp0075845; FBgn0036199.
FBtr0076115; FBpp0075846; FBgn0036199.
GeneIDi39322.
KEGGidme:Dmel_CG7314.
UCSCiCG7314-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50019.1.
AE014296 Genomic DNA. Translation: AAN11881.1.
AY051433 mRNA. Translation: AAK92857.1.
RefSeqiNP_648501.1. NM_140244.5.
NP_729738.1. NM_168472.2.
UniGeneiDm.4611.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0075846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076114; FBpp0075845; FBgn0036199.
FBtr0076115; FBpp0075846; FBgn0036199.
GeneIDi39322.
KEGGidme:Dmel_CG7314.
UCSCiCG7314-RA. d. melanogaster.

Organism-specific databases

CTDi39322.
FlyBaseiFBgn0036199. Bmcp.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
KOiK15106.
OMAiDMDQDLA.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ7K566.

Enzyme and pathway databases

ReactomeiR-DME-167826. The fatty acid cycling model.
R-DME-167827. The proton buffering model.

Miscellaneous databases

GenomeRNAii39322.
PROiQ7K566.

Gene expression databases

BgeeiFBgn0036199.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBMCP_DROME
AccessioniPrimary (citable) accession number: Q7K566
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: October 17, 2006
Last modified: March 15, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Functions as a mitochondrial uncoupling protein when expressed in yeast.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.