Reviewed, UniProtKB/Swiss-Prot Q7K550 (EIF3J_DROME)

Names and origin

Protein names

Recommended name:
    Eukaryotic translation initiation factor 3 subunit J
      Short name=eIF3j

Gene names

Name:	Adam
ORF Names:	CG12131

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Ref.4
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the eIF-3 subunit J family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of translational initiation Ref.4 Inferred from direct assay. Source: UniProtKB translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	eukaryotic translation initiation factor 3 complex Ref.4 Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: UniProtKB translation initiation factor activity Ref.4 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Eukaryotic translation initiation factor 3 subunit J		PRO_0000365135

Sequences

	Sequence		Length	Mass (Da)
	Q7K550-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 38DFB4AEFE875C1E	FASTA	236	26,568
	10 20 30 40 50 60 MADDWESAAD SEVVIRPTAA ASVNKWEGED EDEDIKDSWE DEEEKKDEEK PTKTEAPAKP 70 80 90 100 110 120 KPNKALKAKL EQQALLEEEA EAKRLANLSP AEKLAEKLRL QKIQEASDLK HAQEAFGVTS 130 140 150 160 170 180 TCGGLDAFNP ETKEEFKEFG ATLSWKVGQF RESEHFPQFV EDLVRSLCVN LSAADIKKVK 190 200 210 220 230 MNVEILHSEK LKLEKANAKK PAGKGKGKVT LRTENDDIDG YQKYGNDFTE DYDDFM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
[4]	"The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation." Andersen D.S., Leevers S.J. J. Biol. Chem. 282:14752-14760(2007) [PubMed: 17392269] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH PIX, ASSOCIATION WITH THE 40S RIBOSOME.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF58867.1. AY051457 mRNA. Translation: AAK92881.1.
RefSeq	NP_610541.1.
UniGene	Dm.4603
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7K550.
Proteomic databases
PRIDE	Q7K550.
Genome annotation databases
Ensembl	FBtr0088387; FBpp0087475; FBgn0027619; Drosophila melanogaster. [Genome view]
GeneID	36037.
KEGG	dme:Dmel_CG12131.
NMPDR	fig|7227.3.peg.4347.
UCSC	CG12131-RA. d. melanogaster.
Organism-specific databases
CTD	36037.
FlyBase	FBgn0027619. Adam.
Phylogenomic databases
OMA	DSWDADA
OrthoDB	EOG9SJ5N4
Gene expression databases
ArrayExpress	Q7K550.
Family and domain databases
InterPro	IPR013906. eIF3_subunit. [Graphical view]
PANTHER	PTHR21681. eIF3_subunit. 1 hit.
Pfam	PF08597. eIF3_subunit. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	796490.

Entry information

Entry name

EIF3J_DROME

Accession

Primary (citable) accession number: Q7K550

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	October 3, 2006
Last modified:	November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project