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Protein

Probable protein phosphatase CG10417

Gene

CG10417

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Manganese 1By similarity1
Metal bindingi57Manganese 2By similarity1
Metal bindingi58Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi506Manganese 2By similarity1
Metal bindingi555Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase CG10417 (EC:3.1.3.16)
Gene namesi
ORF Names:CG10417
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033021. CG10417.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003728391 – 662Probable protein phosphatase CG10417Add BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289Phosphoserine1 Publication1
Modified residuei306Phosphoserine1 Publication1
Modified residuei592Phosphoserine1 Publication1
Modified residuei594Phosphoserine1 Publication1
Modified residuei599Phosphoserine1 Publication1
Modified residuei637Phosphothreonine1 Publication1
Modified residuei639Phosphoserine1 Publication1
Modified residuei641Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7K4Q5.
PRIDEiQ7K4Q5.

PTM databases

iPTMnetiQ7K4Q5.

Expressioni

Gene expression databases

BgeeiFBgn0033021.
ExpressionAtlasiQ7K4Q5. baseline.
GenevisibleiQ7K4Q5. DM.

Interactioni

Protein-protein interaction databases

BioGridi61404. 2 interactors.
IntActiQ7K4Q5. 1 interactor.
STRINGi7227.FBpp0085427.

Structurei

3D structure databases

ProteinModelPortaliQ7K4Q5.
SMRiQ7K4Q5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 564PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST542

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi183 – 222Ala-richAdd BLAST40

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00860000133868.
InParanoidiQ7K4Q5.
KOiK17499.
OMAiELHEESH.
OrthoDBiEOG091G0D0W.
PhylomeDBiQ7K4Q5.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7K4Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSHPKT DKTSTDQFNE LLAVGASSMQ GWRNSQEDAH NSILNFDNNT
60 70 80 90 100
SFFAVYDGHG GAEVAQYCAD KLPHFLKNLE TYKNGQFEVA LKEAFLGFDK
110 120 130 140 150
TLLDPSIVSI LKILAGEHNF VDAEADDYEE EDLAELQEES NLPLNEVLEK
160 170 180 190 200
YKGLPQKKDL DLKSSDHKEN FKMRSPYFRG RRAAALAAEA TNKAVMDPSA
210 220 230 240 250
KPDGSSTSAA AAAAALSADG VANSRNPSNV VNPMAGADSN TTTSINDLST
260 270 280 290 300
KNAALKDDSV NDQNEGSNGT DFKHTLVSSS NKKLFATGSN DMTELNQSSK
310 320 330 340 350
NEFTNSSTSK EFERNINSSQ DDEFTDDDAD YEENDNVKSP DTSSAESSDC
360 370 380 390 400
TENDDDGDED GNEDSDEEET DEDQMANDNF CANMIEEPGK DSGCTAVVCL
410 420 430 440 450
LQGRDLYVAN AGDSRCVISR SGQAIEMSID HKPEDDEEAS RIIKAGGRVT
460 470 480 490 500
LDGRVNGGLN LSRALGDHAY KTNVTLPAEE QMISALPDIK KLIITPEDEF
510 520 530 540 550
MVLACDGIWN YMSSEEVVEF VRCRLKDNKK LSTICEELFD NCLAPNTMGD
560 570 580 590 600
GTGCDNMTAV IVQFKKKLQE LQSTIPPNQT EDKLLKTSEN VSHSLNDQSA
610 620 630 640 650
SKRCASQNAD ADDEILEKNN SKRLKTDLEQ ENIKDRTPSP SNQNEDPTQK
660
AIKEVTIIVS SS
Length:662
Mass (Da):72,370
Last modified:October 3, 2006 - v1
Checksum:iC34171B9B030996E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57333.1.
AY051748 mRNA. Translation: AAK93172.1.
RefSeqiNP_610169.1. NM_136325.3.
NP_724410.1. NM_165430.2.
UniGeneiDm.490.

Genome annotation databases

EnsemblMetazoaiFBtr0086091; FBpp0085427; FBgn0033021.
FBtr0086092; FBpp0085428; FBgn0033021.
GeneIDi35492.
KEGGidme:Dmel_CG10417.
UCSCiCG10417-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57333.1.
AY051748 mRNA. Translation: AAK93172.1.
RefSeqiNP_610169.1. NM_136325.3.
NP_724410.1. NM_165430.2.
UniGeneiDm.490.

3D structure databases

ProteinModelPortaliQ7K4Q5.
SMRiQ7K4Q5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61404. 2 interactors.
IntActiQ7K4Q5. 1 interactor.
STRINGi7227.FBpp0085427.

PTM databases

iPTMnetiQ7K4Q5.

Proteomic databases

PaxDbiQ7K4Q5.
PRIDEiQ7K4Q5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086091; FBpp0085427; FBgn0033021.
FBtr0086092; FBpp0085428; FBgn0033021.
GeneIDi35492.
KEGGidme:Dmel_CG10417.
UCSCiCG10417-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0033021. CG10417.

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00860000133868.
InParanoidiQ7K4Q5.
KOiK17499.
OMAiELHEESH.
OrthoDBiEOG091G0D0W.
PhylomeDBiQ7K4Q5.

Miscellaneous databases

ChiTaRSiCG10417. fly.
GenomeRNAii35492.
PROiQ7K4Q5.

Gene expression databases

BgeeiFBgn0033021.
ExpressionAtlasiQ7K4Q5. baseline.
GenevisibleiQ7K4Q5. DM.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY0417_DROME
AccessioniPrimary (citable) accession number: Q7K4Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.