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Protein

Probable protein phosphatase CG10417

Gene

CG10417

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi506 – 5061Manganese 2By similarity
Metal bindingi555 – 5551Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  1. protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase CG10417 (EC:3.1.3.16)
Gene namesi
ORF Names:CG10417
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033021. CG10417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Probable protein phosphatase CG10417PRO_0000372839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891Phosphoserine1 Publication
Modified residuei306 – 3061Phosphoserine1 Publication
Modified residuei592 – 5921Phosphoserine1 Publication
Modified residuei594 – 5941Phosphoserine1 Publication
Modified residuei599 – 5991Phosphoserine1 Publication
Modified residuei637 – 6371Phosphothreonine1 Publication
Modified residuei639 – 6391Phosphoserine1 Publication
Modified residuei641 – 6411Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7K4Q5.
PRIDEiQ7K4Q5.

Expressioni

Gene expression databases

BgeeiQ7K4Q5.
ExpressionAtlasiQ7K4Q5. differential.

Interactioni

Protein-protein interaction databases

BioGridi61404. 2 interactions.
IntActiQ7K4Q5. 1 interaction.
STRINGi7227.FBpp0085428.

Structurei

3D structure databases

ProteinModelPortaliQ7K4Q5.
SMRiQ7K4Q5. Positions 1-117, 387-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 22240Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
InParanoidiQ7K4Q5.
KOiK17499.
OMAiIWNSMES.
OrthoDBiEOG7034GD.
PhylomeDBiQ7K4Q5.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7K4Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSHPKT DKTSTDQFNE LLAVGASSMQ GWRNSQEDAH NSILNFDNNT
60 70 80 90 100
SFFAVYDGHG GAEVAQYCAD KLPHFLKNLE TYKNGQFEVA LKEAFLGFDK
110 120 130 140 150
TLLDPSIVSI LKILAGEHNF VDAEADDYEE EDLAELQEES NLPLNEVLEK
160 170 180 190 200
YKGLPQKKDL DLKSSDHKEN FKMRSPYFRG RRAAALAAEA TNKAVMDPSA
210 220 230 240 250
KPDGSSTSAA AAAAALSADG VANSRNPSNV VNPMAGADSN TTTSINDLST
260 270 280 290 300
KNAALKDDSV NDQNEGSNGT DFKHTLVSSS NKKLFATGSN DMTELNQSSK
310 320 330 340 350
NEFTNSSTSK EFERNINSSQ DDEFTDDDAD YEENDNVKSP DTSSAESSDC
360 370 380 390 400
TENDDDGDED GNEDSDEEET DEDQMANDNF CANMIEEPGK DSGCTAVVCL
410 420 430 440 450
LQGRDLYVAN AGDSRCVISR SGQAIEMSID HKPEDDEEAS RIIKAGGRVT
460 470 480 490 500
LDGRVNGGLN LSRALGDHAY KTNVTLPAEE QMISALPDIK KLIITPEDEF
510 520 530 540 550
MVLACDGIWN YMSSEEVVEF VRCRLKDNKK LSTICEELFD NCLAPNTMGD
560 570 580 590 600
GTGCDNMTAV IVQFKKKLQE LQSTIPPNQT EDKLLKTSEN VSHSLNDQSA
610 620 630 640 650
SKRCASQNAD ADDEILEKNN SKRLKTDLEQ ENIKDRTPSP SNQNEDPTQK
660
AIKEVTIIVS SS
Length:662
Mass (Da):72,370
Last modified:October 3, 2006 - v1
Checksum:iC34171B9B030996E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57333.1.
AY051748 mRNA. Translation: AAK93172.1.
RefSeqiNP_610169.1. NM_136325.3.
NP_724410.1. NM_165430.2.
UniGeneiDm.490.

Genome annotation databases

EnsemblMetazoaiFBtr0086091; FBpp0085427; FBgn0033021.
FBtr0086092; FBpp0085428; FBgn0033021.
GeneIDi35492.
KEGGidme:Dmel_CG10417.
UCSCiCG10417-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57333.1.
AY051748 mRNA. Translation: AAK93172.1.
RefSeqiNP_610169.1. NM_136325.3.
NP_724410.1. NM_165430.2.
UniGeneiDm.490.

3D structure databases

ProteinModelPortaliQ7K4Q5.
SMRiQ7K4Q5. Positions 1-117, 387-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61404. 2 interactions.
IntActiQ7K4Q5. 1 interaction.
STRINGi7227.FBpp0085428.

Proteomic databases

PaxDbiQ7K4Q5.
PRIDEiQ7K4Q5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086091; FBpp0085427; FBgn0033021.
FBtr0086092; FBpp0085428; FBgn0033021.
GeneIDi35492.
KEGGidme:Dmel_CG10417.
UCSCiCG10417-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0033021. CG10417.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
InParanoidiQ7K4Q5.
KOiK17499.
OMAiIWNSMES.
OrthoDBiEOG7034GD.
PhylomeDBiQ7K4Q5.

Miscellaneous databases

ChiTaRSiCG10417. fly.
GenomeRNAii35492.
NextBioi793693.
PROiQ7K4Q5.

Gene expression databases

BgeeiQ7K4Q5.
ExpressionAtlasiQ7K4Q5. differential.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-592; SER-594; SER-599; THR-637; SER-639 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiY0417_DROME
AccessioniPrimary (citable) accession number: Q7K4Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 3, 2006
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.