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Q7K4Q5 (Y0417_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase CG10417

EC=3.1.3.16
Gene names
ORF Names:CG10417
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Probable protein phosphatase CG10417
PRO_0000372839

Regions

Compositional bias183 – 22240Ala-rich

Sites

Metal binding571Manganese 1 By similarity
Metal binding571Manganese 2 By similarity
Metal binding581Manganese 1; via carbonyl oxygen By similarity
Metal binding5061Manganese 2 By similarity
Metal binding5551Manganese 2 By similarity

Amino acid modifications

Modified residue2891Phosphoserine Ref.4
Modified residue3061Phosphoserine Ref.5
Modified residue5921Phosphoserine Ref.5
Modified residue5941Phosphoserine Ref.5
Modified residue5991Phosphoserine Ref.5
Modified residue6371Phosphothreonine Ref.5
Modified residue6391Phosphoserine Ref.5
Modified residue6411Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q7K4Q5 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: C34171B9B030996E

FASTA66272,370
        10         20         30         40         50         60 
MGAYLSHPKT DKTSTDQFNE LLAVGASSMQ GWRNSQEDAH NSILNFDNNT SFFAVYDGHG 

        70         80         90        100        110        120 
GAEVAQYCAD KLPHFLKNLE TYKNGQFEVA LKEAFLGFDK TLLDPSIVSI LKILAGEHNF 

       130        140        150        160        170        180 
VDAEADDYEE EDLAELQEES NLPLNEVLEK YKGLPQKKDL DLKSSDHKEN FKMRSPYFRG 

       190        200        210        220        230        240 
RRAAALAAEA TNKAVMDPSA KPDGSSTSAA AAAAALSADG VANSRNPSNV VNPMAGADSN 

       250        260        270        280        290        300 
TTTSINDLST KNAALKDDSV NDQNEGSNGT DFKHTLVSSS NKKLFATGSN DMTELNQSSK 

       310        320        330        340        350        360 
NEFTNSSTSK EFERNINSSQ DDEFTDDDAD YEENDNVKSP DTSSAESSDC TENDDDGDED 

       370        380        390        400        410        420 
GNEDSDEEET DEDQMANDNF CANMIEEPGK DSGCTAVVCL LQGRDLYVAN AGDSRCVISR 

       430        440        450        460        470        480 
SGQAIEMSID HKPEDDEEAS RIIKAGGRVT LDGRVNGGLN LSRALGDHAY KTNVTLPAEE 

       490        500        510        520        530        540 
QMISALPDIK KLIITPEDEF MVLACDGIWN YMSSEEVVEF VRCRLKDNKK LSTICEELFD 

       550        560        570        580        590        600 
NCLAPNTMGD GTGCDNMTAV IVQFKKKLQE LQSTIPPNQT EDKLLKTSEN VSHSLNDQSA 

       610        620        630        640        650        660 
SKRCASQNAD ADDEILEKNN SKRLKTDLEQ ENIKDRTPSP SNQNEDPTQK AIKEVTIIVS 


SS 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-592; SER-594; SER-599; THR-637; SER-639 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013599 Genomic DNA. Translation: AAF57333.1.
AY051748 mRNA. Translation: AAK93172.1.
RefSeqNP_610169.1. NM_136325.3.
NP_724410.1. NM_165430.2.
UniGeneDm.490.

3D structure databases

ProteinModelPortalQ7K4Q5.
SMRQ7K4Q5. Positions 1-117, 387-565.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid61404. 2 interactions.
STRING7227.FBpp0085428.

Proteomic databases

PaxDbQ7K4Q5.
PRIDEQ7K4Q5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0086091; FBpp0085427; FBgn0033021.
FBtr0086092; FBpp0085428; FBgn0033021.
GeneID35492.
KEGGdme:Dmel_CG10417.
UCSCCG10417-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0033021. CG10417.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00730000110861.
InParanoidQ7K4Q5.
KOK17499.
OMAIWNSMES.
OrthoDBEOG7034GD.
PhylomeDBQ7K4Q5.

Gene expression databases

BgeeQ7K4Q5.

Family and domain databases

Gene3D3.60.40.10. 2 hits.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 2 hits.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi35492.
NextBio793693.
PROQ7K4Q5.

Entry information

Entry nameY0417_DROME
AccessionPrimary (citable) accession number: Q7K4Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase