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Q7K4Q5

- Y0417_DROME

UniProt

Q7K4Q5 - Y0417_DROME

Protein

Probable protein phosphatase CG10417

Gene

CG10417

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Manganese 1By similarity
    Metal bindingi57 – 571Manganese 2By similarity
    Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi506 – 5061Manganese 2By similarity
    Metal bindingi555 – 5551Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: FlyBase

    GO - Biological processi

    1. protein dephosphorylation Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase CG10417 (EC:3.1.3.16)
    Gene namesi
    ORF Names:CG10417
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0033021. CG10417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 662662Probable protein phosphatase CG10417PRO_0000372839Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei289 – 2891Phosphoserine1 Publication
    Modified residuei306 – 3061Phosphoserine1 Publication
    Modified residuei592 – 5921Phosphoserine1 Publication
    Modified residuei594 – 5941Phosphoserine1 Publication
    Modified residuei599 – 5991Phosphoserine1 Publication
    Modified residuei637 – 6371Phosphothreonine1 Publication
    Modified residuei639 – 6391Phosphoserine1 Publication
    Modified residuei641 – 6411Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ7K4Q5.
    PRIDEiQ7K4Q5.

    Expressioni

    Gene expression databases

    BgeeiQ7K4Q5.

    Interactioni

    Protein-protein interaction databases

    BioGridi61404. 2 interactions.
    STRINGi7227.FBpp0085428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7K4Q5.
    SMRiQ7K4Q5. Positions 1-117, 387-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi183 – 22240Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00730000110861.
    InParanoidiQ7K4Q5.
    KOiK17499.
    OMAiIWNSMES.
    OrthoDBiEOG7034GD.
    PhylomeDBiQ7K4Q5.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7K4Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAYLSHPKT DKTSTDQFNE LLAVGASSMQ GWRNSQEDAH NSILNFDNNT    50
    SFFAVYDGHG GAEVAQYCAD KLPHFLKNLE TYKNGQFEVA LKEAFLGFDK 100
    TLLDPSIVSI LKILAGEHNF VDAEADDYEE EDLAELQEES NLPLNEVLEK 150
    YKGLPQKKDL DLKSSDHKEN FKMRSPYFRG RRAAALAAEA TNKAVMDPSA 200
    KPDGSSTSAA AAAAALSADG VANSRNPSNV VNPMAGADSN TTTSINDLST 250
    KNAALKDDSV NDQNEGSNGT DFKHTLVSSS NKKLFATGSN DMTELNQSSK 300
    NEFTNSSTSK EFERNINSSQ DDEFTDDDAD YEENDNVKSP DTSSAESSDC 350
    TENDDDGDED GNEDSDEEET DEDQMANDNF CANMIEEPGK DSGCTAVVCL 400
    LQGRDLYVAN AGDSRCVISR SGQAIEMSID HKPEDDEEAS RIIKAGGRVT 450
    LDGRVNGGLN LSRALGDHAY KTNVTLPAEE QMISALPDIK KLIITPEDEF 500
    MVLACDGIWN YMSSEEVVEF VRCRLKDNKK LSTICEELFD NCLAPNTMGD 550
    GTGCDNMTAV IVQFKKKLQE LQSTIPPNQT EDKLLKTSEN VSHSLNDQSA 600
    SKRCASQNAD ADDEILEKNN SKRLKTDLEQ ENIKDRTPSP SNQNEDPTQK 650
    AIKEVTIIVS SS 662
    Length:662
    Mass (Da):72,370
    Last modified:October 3, 2006 - v1
    Checksum:iC34171B9B030996E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF57333.1.
    AY051748 mRNA. Translation: AAK93172.1.
    RefSeqiNP_610169.1. NM_136325.3.
    NP_724410.1. NM_165430.2.
    UniGeneiDm.490.

    Genome annotation databases

    EnsemblMetazoaiFBtr0086091; FBpp0085427; FBgn0033021.
    FBtr0086092; FBpp0085428; FBgn0033021.
    GeneIDi35492.
    KEGGidme:Dmel_CG10417.
    UCSCiCG10417-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF57333.1 .
    AY051748 mRNA. Translation: AAK93172.1 .
    RefSeqi NP_610169.1. NM_136325.3.
    NP_724410.1. NM_165430.2.
    UniGenei Dm.490.

    3D structure databases

    ProteinModelPortali Q7K4Q5.
    SMRi Q7K4Q5. Positions 1-117, 387-565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61404. 2 interactions.
    STRINGi 7227.FBpp0085428.

    Proteomic databases

    PaxDbi Q7K4Q5.
    PRIDEi Q7K4Q5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0086091 ; FBpp0085427 ; FBgn0033021 .
    FBtr0086092 ; FBpp0085428 ; FBgn0033021 .
    GeneIDi 35492.
    KEGGi dme:Dmel_CG10417.
    UCSCi CG10417-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0033021. CG10417.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00730000110861.
    InParanoidi Q7K4Q5.
    KOi K17499.
    OMAi IWNSMES.
    OrthoDBi EOG7034GD.
    PhylomeDBi Q7K4Q5.

    Miscellaneous databases

    GenomeRNAii 35492.
    NextBioi 793693.
    PROi Q7K4Q5.

    Gene expression databases

    Bgeei Q7K4Q5.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
      Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
      Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-592; SER-594; SER-599; THR-637; SER-639 AND SER-641, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiY0417_DROME
    AccessioniPrimary (citable) accession number: Q7K4Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3