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Protein
Submitted name:

CathD

Gene

cathD

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91PROSITE-ProRule annotation1
Active sitei277PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: FlyBase
  • autophagic cell death Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central
  • salivary gland cell autophagic cell death Source: FlyBase

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-DME-1442490. Collagen degradation.
R-DME-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-DME-2132295. MHC class II antigen presentation.
R-DME-5683826. Surfactant metabolism.
R-DME-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Submitted name:
CathDImported (EC:3.4.23.-Imported)
Submitted name:
Cathepsin DImported
Submitted name:
SD07085pImported
Gene namesi
Name:cathDImported
ORF Names:CG1548Imported, Dmel_CG1548Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0029093. cathD.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
  • lysosome Source: FlyBase
  • microtubule associated complex Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500971450218 – 392Sequence analysisAdd BLAST375

Expressioni

Gene expression databases

BgeeiFBgn0029093.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087972.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 389Peptidase A1InterPro annotationAdd BLAST317

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
KOiK01379.
OMAiDLQLCKG.
OrthoDBiEOG091G0JP7.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF487. PTHR13683:SF487. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7K485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKVALLLVA FLAAAVAHPN SQEKPGLLRV PLHKFQSARR HFADVGTELQ
60 70 80 90 100
QLRIRYGGGD VPEPLSNYMD AQYYGPIAIG SPPQNFRVVF DTGSSNLWVP
110 120 130 140 150
SKKCHLTNIA CLMHNKYDAS KSKTYTKNGT EFAIQYGSGS LSGYLSTDTV
160 170 180 190 200
SIAGLDIKDQ TFAEALSEPG LVFVAAKFDG ILGLGYNSIS VDKVKPPFYA
210 220 230 240 250
MYEQGLISAP VFSFYLNRDP ASPEGGEIIF GGSDPNHYTG EFTYLPVTRK
260 270 280 290 300
AYWQIKMDAA SIGDLQLCKG GCQVIADTGT SLIAAPLEEA TSINQKIGGT
310 320 330 340 350
PIIGGQYVVS CDLIPQLPVI KFVLGGKTFE LEGKDYILRV AQMGKTICLS
360 370 380 390
GFMGLDIPPP NGPLWILGDV FIGKYYTEFD MGNDRVGFAD AK
Length:392
Mass (Da):42,473
Last modified:October 3, 2006 - v1
Checksum:i022E7F5C09BE43F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220040 mRNA. Translation: AAF23824.1.
AE013599 Genomic DNA. Translation: AAF59186.1.
AY052119 mRNA. Translation: AAK93543.1.
RefSeqiNP_001334713.1. NM_001347752.1.
NP_001334714.1. NM_001347753.1.
NP_652013.1. NM_143756.3.
UniGeneiDm.3355.

Genome annotation databases

EnsemblMetazoaiFBtr0088898; FBpp0087972; FBgn0029093.
GeneIDi45268.
KEGGidme:Dmel_CG1548.
UCSCiCG1548-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220040 mRNA. Translation: AAF23824.1.
AE013599 Genomic DNA. Translation: AAF59186.1.
AY052119 mRNA. Translation: AAK93543.1.
RefSeqiNP_001334713.1. NM_001347752.1.
NP_001334714.1. NM_001347753.1.
NP_652013.1. NM_143756.3.
UniGeneiDm.3355.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087972.

Protein family/group databases

MEROPSiA01.009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088898; FBpp0087972; FBgn0029093.
GeneIDi45268.
KEGGidme:Dmel_CG1548.
UCSCiCG1548-RA. d. melanogaster.

Organism-specific databases

CTDi45268.
FlyBaseiFBgn0029093. cathD.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
KOiK01379.
OMAiDLQLCKG.
OrthoDBiEOG091G0JP7.

Enzyme and pathway databases

ReactomeiR-DME-1442490. Collagen degradation.
R-DME-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-DME-2132295. MHC class II antigen presentation.
R-DME-5683826. Surfactant metabolism.
R-DME-6798695. Neutrophil degranulation.

Miscellaneous databases

GenomeRNAii45268.

Gene expression databases

BgeeiFBgn0029093.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF487. PTHR13683:SF487. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ7K485_DROME
AccessioniPrimary (citable) accession number: Q7K485
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: March 15, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.