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Protein
Submitted name:

DHX15 ortholog, isoform A

Gene

Dhx15

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: FlyBase
  • nucleotidyltransferase activity Source: UniProtKB-KW
  • RNA binding Source: GO_Central
  • RNA helicase activity Source: FlyBase

GO - Biological processi

  • mRNA splicing, via spliceosome Source: FlyBase
  • positive regulation of p38MAPK cascade Source: FlyBase

Keywordsi

Molecular functionHydrolaseSAAS annotationImported, NucleotidyltransferaseImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
DHX15 ortholog, isoform AImported (EC:2.7.7.-Imported, EC:3.6.1.3Imported)
Submitted name:
DHX15 ortholog, isoform BImported
Submitted name:
GM13272pImported
Gene namesi
Name:Dhx15Imported
Synonyms:CG11107Imported
ORF Names:Dmel_CG11107Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033160. Dhx15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0033160.

Interactioni

Protein-protein interaction databases

IntActiQ7K3M5. 5 interactors.
STRINGi7227.FBpp0088040.

Structurei

3D structure databases

SMRiQ7K3M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 246Helicase ATP-bindingInterPro annotationAdd BLAST165
Domaini271 – 451Helicase C-terminalInterPro annotationAdd BLAST181

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00900000140964.
KOiK12820.
OMAiQWCVDFA.
OrthoDBiEOG091G030Q.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7K3M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRRIEVGE TYGSKAKKDP EASSSSAAAA AGTVAQILGG FVPNKQPPTM
60 70 80 90 100
NPLTNTPYSQ RYQNLYKKRI ALPVFEYQAD FMRLLSLHQC IVLVGETGSG
110 120 130 140 150
KTTQIPQWCV DFAVSKGRKG VSCTQPRRVA AMSVAQRVSE EMDVKLGEEV
160 170 180 190 200
GYSIRFEDCS TAKTLLKYMT DGMLLREAMS DPMLDQYQVI LLDEAHERTL
210 220 230 240 250
ATDILMGVLK EVIRQRSDLK LVVMSATLDA GKFQQYFDNA PLMKVPGRTH
260 270 280 290 300
PVEIFYTPEP ERDYLEAAIR TVIQIHMCEE IEGDILMFLT GQEEIEEACK
310 320 330 340 350
RIKREIDNLG SEIGELKCIP LYSTLPPNLQ QRIFEPAPPP NANGAIGRKV
360 370 380 390 400
VVSTNIAETS LTIDGVVFVI DPGFAKQKVY NPRIRVESLL VSPISKASAQ
410 420 430 440 450
QRSGRAGRTR PGKCFRLYTE KAFKNEMQDN TYPEILRSNL GTVVLQLKKL
460 470 480 490 500
GIDDLVHFDF MDPPAPETLM RALELLNYLA ALDDDGNLTD LGAVMSEFPL
510 520 530 540 550
DPQLAKMLIA SCQHNCSNEI LSITAMLSVP QCFVRPNEAK KAADEAKMRF
560 570 580 590 600
AHIDGDHLTL LNVYHAFKQS SEDPNWCYEN FINFRSLKSA DNVRQQLARI
610 620 630 640 650
MDRFNLRRTS TEFTSKDYYV NIRKALVQGF FMQVAHLERT GYYLTIKDNQ
660 670 680 690 700
NVQLHPSTCL DHKPDWVIYN EFVLTTKNYI RTVTDVKPEW LCCLAPQYYD
710 720
LNNFPQCEAK RQLELLQQRL ETKQYQKGF
Length:729
Mass (Da):82,652
Last modified:October 3, 2006 - v1
Checksum:i5C14D4338E6403A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF59269.1.
AY058484 mRNA. Translation: AAL13713.1.
AE013599 Genomic DNA. Translation: AGB93299.1.
RefSeqiNP_001260766.1. NM_001273837.1.
NP_610269.1. NM_136425.3.
UniGeneiDm.4189.

Genome annotation databases

EnsemblMetazoaiFBtr0088966; FBpp0088040; FBgn0033160.
FBtr0336909; FBpp0307849; FBgn0033160.
GeneIDi35654.
KEGGidme:Dmel_CG11107.
UCSCiCG11107-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ7K3M5_DROME
AccessioniPrimary (citable) accession number: Q7K3M5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported