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Protein
Submitted name:

DHX15 ortholog, isoform A

Gene

Dhx15

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: FlyBase
  • nucleotidyltransferase activity Source: UniProtKB-KW
  • RNA binding Source: GO_Central
  • RNA helicase activity Source: FlyBase

GO - Biological processi

  • mRNA splicing, via spliceosome Source: FlyBase
  • positive regulation of p38MAPK cascade Source: FlyBase

Keywordsi

Molecular functionHydrolaseSAAS annotationImported, NucleotidyltransferaseImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Submitted name:
DHX15 ortholog, isoform AImported (EC:2.7.7.-Imported, EC:3.6.1.3Imported)
Submitted name:
DHX15 ortholog, isoform BImported
Submitted name:
GM13272pImported
Gene namesi
Name:Dhx15Imported
ORF Names:CG11107Imported, Dmel_CG11107Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033160 Dhx15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0033160

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0088040

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 246Helicase ATP-bindingInterPro annotationAdd BLAST165
Domaini271 – 451Helicase C-terminalInterPro annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili292 – 312Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0925 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00910000144017
KOiK12820
OMAiQWCVDFA
OrthoDBiEOG091G030Q

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q7K3M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRRIEVGE TYGSKAKKDP EASSSSAAAA AGTVAQILGG FVPNKQPPTM
60 70 80 90 100
NPLTNTPYSQ RYQNLYKKRI ALPVFEYQAD FMRLLSLHQC IVLVGETGSG
110 120 130 140 150
KTTQIPQWCV DFAVSKGRKG VSCTQPRRVA AMSVAQRVSE EMDVKLGEEV
160 170 180 190 200
GYSIRFEDCS TAKTLLKYMT DGMLLREAMS DPMLDQYQVI LLDEAHERTL
210 220 230 240 250
ATDILMGVLK EVIRQRSDLK LVVMSATLDA GKFQQYFDNA PLMKVPGRTH
260 270 280 290 300
PVEIFYTPEP ERDYLEAAIR TVIQIHMCEE IEGDILMFLT GQEEIEEACK
310 320 330 340 350
RIKREIDNLG SEIGELKCIP LYSTLPPNLQ QRIFEPAPPP NANGAIGRKV
360 370 380 390 400
VVSTNIAETS LTIDGVVFVI DPGFAKQKVY NPRIRVESLL VSPISKASAQ
410 420 430 440 450
QRSGRAGRTR PGKCFRLYTE KAFKNEMQDN TYPEILRSNL GTVVLQLKKL
460 470 480 490 500
GIDDLVHFDF MDPPAPETLM RALELLNYLA ALDDDGNLTD LGAVMSEFPL
510 520 530 540 550
DPQLAKMLIA SCQHNCSNEI LSITAMLSVP QCFVRPNEAK KAADEAKMRF
560 570 580 590 600
AHIDGDHLTL LNVYHAFKQS SEDPNWCYEN FINFRSLKSA DNVRQQLARI
610 620 630 640 650
MDRFNLRRTS TEFTSKDYYV NIRKALVQGF FMQVAHLERT GYYLTIKDNQ
660 670 680 690 700
NVQLHPSTCL DHKPDWVIYN EFVLTTKNYI RTVTDVKPEW LCCLAPQYYD
710 720
LNNFPQCEAK RQLELLQQRL ETKQYQKGF
Length:729
Mass (Da):82,652
Last modified:October 3, 2006 - v1
Checksum:i5C14D4338E6403A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59269.1
AY058484 mRNA Translation: AAL13713.1
AE013599 Genomic DNA Translation: AGB93299.1
RefSeqiNP_001260766.1, NM_001273837.1
NP_610269.1, NM_136425.3
UniGeneiDm.4189

Genome annotation databases

EnsemblMetazoaiFBtr0088966; FBpp0088040; FBgn0033160
FBtr0336909; FBpp0307849; FBgn0033160
GeneIDi35654
KEGGidme:Dmel_CG11107
UCSCiCG11107-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ7K3M5_DROME
AccessioniPrimary (citable) accession number: Q7K3M5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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