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Protein
Submitted name:

LD20892p

Gene

Myd88

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase
  • Toll binding Source: FlyBase

GO - Biological processi

  • antifungal peptide production Source: FlyBase
  • defense response to fungus Source: FlyBase
  • defense response to Gram-positive bacterium Source: FlyBase
  • dorsal/ventral pattern formation Source: FlyBase
  • immune response Source: FlyBase
  • innate immune response Source: FlyBase
  • positive regulation of antifungal peptide production Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • response to fungus Source: FlyBase
  • Toll signaling pathway Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-1810476. RIP-mediated NFkB activation via ZBP1.
R-DME-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-DME-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DME-933542. TRAF6 mediated NF-kB activation.
R-DME-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-DME-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-DME-975155. MyD88 dependent cascade initiated on endosome.

Names & Taxonomyi

Protein namesi
Submitted name:
LD20892pImported
Submitted name:
MyD88 adapter proteinImported
Submitted name:
Myd88, isoform AImported
Submitted name:
Myd88, isoform BImported
Submitted name:
Myd88, isoform CImported
Gene namesi
Name:Myd88Imported
ORF Names:CG2078Imported, Dmel_CG2078Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033402. Myd88.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0033402.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TlP089533EBI-129988,EBI-143610

GO - Molecular functioni

  • Toll binding Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0305215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 341TIRInterPro annotationAdd BLAST101

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
GeneTreeiENSGT00510000048324.
HOGENOMiHOG000243425.
KOiK04729.
OMAiLPRYNAC.
OrthoDBiEOG091G0NDI.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13676. TIR_2. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7K105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRFVCHQQ HSVAHSHYQP HSHFHHHTHR HPNPPHHHHI YGATDVSYRR
60 70 80 90 100
YRTAGMVVAE GVMDSGSGSG TGTGLGHFNE TPLSALGIET RTQLSRMLNR
110 120 130 140 150
KKVLRSEEGY QRDWRGISEL AKQKGFVDEN ANNPMDLVLI SWSQRSPQTA
160 170 180 190 200
KVGHLEHFLG IIDRWDVCDD IQENLAKDTQ RFIMKQEQRQ TALVEACPPP
210 220 230 240 250
PSDCFETNNN YSSSNNITVG QSVQILSDED QRCVQMGQPL PRYNACVLYA
260 270 280 290 300
EADIDHATEI MNNLESERYN LRLFLRHRDM LMGVPFEHVQ LSHFMATRCN
310 320 330 340 350
HLIVVLTEEF LRSPENTYLV NFTQKIQIEN HTRKIIPILY KTDMHIPQTL
360 370 380 390 400
GIYTHIKYAG DSKLFNFWDK LARSLHDLDA FSIYSTRQVQ TPSPVEESAP
410 420 430 440 450
RVTTPSIRIQ INDKDVTDMP NYNSCKVPEA ETTIVSVSGD TGSPLPEHKP
460 470 480 490 500
KKKDRFLRRI THSFGKTARS DGASGKTLRH AHSVSTINVT ERERTLSASS
510 520 530
SNISTTSESK KSFIKWQPNI LKKALFSRSS SKLQTPG
Length:537
Mass (Da):61,163
Last modified:October 3, 2006 - v1
Checksum:i4AA9E9F89EF2D79F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58953.1.
AY069468 mRNA. Translation: AAL39613.1.
AF422803 mRNA. Translation: AAL56570.1.
AE013599 Genomic DNA. Translation: AGB93354.1.
AE013599 Genomic DNA. Translation: AHN56044.1.
RefSeqiNP_001260821.1. NM_001273892.1.
NP_001286246.1. NM_001299317.1.
NP_610479.1. NM_136635.3.
UniGeneiDm.2113.

Genome annotation databases

EnsemblMetazoaiFBtr0088598; FBpp0087679; FBgn0033402.
FBtr0333000; FBpp0305215; FBgn0033402.
FBtr0345024; FBpp0311274; FBgn0033402.
GeneIDi35956.
KEGGidme:Dmel_CG2078.
UCSCiCG2078-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58953.1.
AY069468 mRNA. Translation: AAL39613.1.
AF422803 mRNA. Translation: AAL56570.1.
AE013599 Genomic DNA. Translation: AGB93354.1.
AE013599 Genomic DNA. Translation: AHN56044.1.
RefSeqiNP_001260821.1. NM_001273892.1.
NP_001286246.1. NM_001299317.1.
NP_610479.1. NM_136635.3.
UniGeneiDm.2113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0305215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088598; FBpp0087679; FBgn0033402.
FBtr0333000; FBpp0305215; FBgn0033402.
FBtr0345024; FBpp0311274; FBgn0033402.
GeneIDi35956.
KEGGidme:Dmel_CG2078.
UCSCiCG2078-RA. d. melanogaster.

Organism-specific databases

CTDi4615.
FlyBaseiFBgn0033402. Myd88.

Phylogenomic databases

eggNOGiENOG410IIN8. Eukaryota.
ENOG410ZIY0. LUCA.
GeneTreeiENSGT00510000048324.
HOGENOMiHOG000243425.
KOiK04729.
OMAiLPRYNAC.
OrthoDBiEOG091G0NDI.

Enzyme and pathway databases

ReactomeiR-DME-1810476. RIP-mediated NFkB activation via ZBP1.
R-DME-3134963. DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
R-DME-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DME-933542. TRAF6 mediated NF-kB activation.
R-DME-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-DME-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-DME-975155. MyD88 dependent cascade initiated on endosome.

Miscellaneous databases

GenomeRNAii35956.
PROiQ7K105.

Gene expression databases

BgeeiFBgn0033402.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.10140. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13676. TIR_2. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7K105_DROME
AccessioniPrimary (citable) accession number: Q7K105
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.