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Protein

Hexokinase

Gene

Hex-C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • carbohydrate phosphorylation Source: GOC
  • cellular glucose homeostasis Source: GO_Central
  • glucose 6-phosphate metabolic process Source: GOC
  • glycolytic process Source: GO_Central
  • lateral inhibition Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_307214. Regulation of gene expression in beta cells.
REACT_319845. Glycolysis.
REACT_340255. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_342895. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Hex-CImported
ORF Names:CG8094Imported, Dmel_CG8094Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001187. Hex-C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086530.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
KOiK00844.
OMAiCLAKFVE.
OrthoDBiEOG7S21X5.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7JYW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDAEVRELM QPFVLSDYQV QEVYSRFCLE VARGLKRSTH PQANVKCFPT
60 70 80 90 100
YVQDLPTGDE MGKYLALDLG GTNFRVLLVS LKGHHDATVD SQIYAVPKDL
110 120 130 140 150
MVGPGVDLFD HIAGCLAKFV EKHDMKTAYL PLGFTFSFPC VQLGLKEGIL
160 170 180 190 200
VRWTKGFDCA GVEGEDVGRM LHEAIQRRGD ADIAVVAILN DTTGTLMSCA
210 220 230 240 250
HRNADCRVGV IVGTGCNACY VEDVENVDLL RADFKKTKRS VIVNAEWGAF
260 270 280 290 300
GEGGQLDFVR TEYDREVDEK SLNRSEQLFE KMTAGMYLGN LVRLVLLRAL
310 320 330 340 350
ERKLIFKQSS RRPEFASVLQ RNEEVFETRY ISEIEDDSFP EFASTRKIVK
360 370 380 390 400
NLFGLEKASV EDCQTLRYIC ECVAKRAATL VAIGVSGLVN RTSNRRVIVG
410 420 430 440 450
MDGSVYRYHP KFDAYMRQTL QKLVKADKEW DIMLSEDGSG RGAALVAAVA

SKTK
Length:454
Mass (Da):50,738
Last modified:October 3, 2006 - v1
Checksum:i57B3E6254F63710F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58160.1.
AF237469 mRNA. Translation: AAG10690.1.
AF257540 Genomic DNA. Translation: AAG23064.1.
AF257541 Genomic DNA. Translation: AAG23065.1.
AF257543 Genomic DNA. Translation: AAG23067.1.
AF257546 Genomic DNA. Translation: AAG23070.1.
AF257547 Genomic DNA. Translation: AAG23071.1.
AF257549 Genomic DNA. Translation: AAG23073.1.
AF257551 Genomic DNA. Translation: AAG23075.1.
AF257554 Genomic DNA. Translation: AAG23078.1.
AF257555 Genomic DNA. Translation: AAG23079.1.
AF257558 Genomic DNA. Translation: AAG23082.1.
AF257561 Genomic DNA. Translation: AAG23085.1.
AF257564 Genomic DNA. Translation: AAG23088.1.
AF257565 Genomic DNA. Translation: AAG23089.1.
AF257567 Genomic DNA. Translation: AAG23091.1.
AF257568 Genomic DNA. Translation: AAG23092.1.
AF257570 Genomic DNA. Translation: AAG23094.1.
AF257571 Genomic DNA. Translation: AAG23095.1.
AF257573 Genomic DNA. Translation: AAG23097.1.
AF257574 Genomic DNA. Translation: AAG23098.1.
AF257575 Genomic DNA. Translation: AAG23099.1.
AF257576 Genomic DNA. Translation: AAG23100.1.
AF257577 Genomic DNA. Translation: AAG23101.1.
AF257578 Genomic DNA. Translation: AAG23102.1.
AF257581 Genomic DNA. Translation: AAG23105.1.
AF257582 Genomic DNA. Translation: AAG23106.1.
AF257583 Genomic DNA. Translation: AAG23107.1.
AF257585 Genomic DNA. Translation: AAG23109.1.
AF257587 Genomic DNA. Translation: AAG23111.1.
AF257588 Genomic DNA. Translation: AAG23112.1.
AF257589 Genomic DNA. Translation: AAG23113.1.
AY070657 mRNA. Translation: AAL48128.1.
AY071719 mRNA. Translation: AAL49341.1.
AJ309864 Genomic DNA. Translation: CAC34564.1.
RefSeqiNP_524674.1. NM_079935.4.
UniGeneiDm.1873.

Genome annotation databases

EnsemblMetazoaiFBtr0087399; FBpp0086530; FBgn0001187.
GeneIDi44008.
KEGGidme:Dmel_CG8094.
UCSCiCG8094-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58160.1.
AF237469 mRNA. Translation: AAG10690.1.
AF257540 Genomic DNA. Translation: AAG23064.1.
AF257541 Genomic DNA. Translation: AAG23065.1.
AF257543 Genomic DNA. Translation: AAG23067.1.
AF257546 Genomic DNA. Translation: AAG23070.1.
AF257547 Genomic DNA. Translation: AAG23071.1.
AF257549 Genomic DNA. Translation: AAG23073.1.
AF257551 Genomic DNA. Translation: AAG23075.1.
AF257554 Genomic DNA. Translation: AAG23078.1.
AF257555 Genomic DNA. Translation: AAG23079.1.
AF257558 Genomic DNA. Translation: AAG23082.1.
AF257561 Genomic DNA. Translation: AAG23085.1.
AF257564 Genomic DNA. Translation: AAG23088.1.
AF257565 Genomic DNA. Translation: AAG23089.1.
AF257567 Genomic DNA. Translation: AAG23091.1.
AF257568 Genomic DNA. Translation: AAG23092.1.
AF257570 Genomic DNA. Translation: AAG23094.1.
AF257571 Genomic DNA. Translation: AAG23095.1.
AF257573 Genomic DNA. Translation: AAG23097.1.
AF257574 Genomic DNA. Translation: AAG23098.1.
AF257575 Genomic DNA. Translation: AAG23099.1.
AF257576 Genomic DNA. Translation: AAG23100.1.
AF257577 Genomic DNA. Translation: AAG23101.1.
AF257578 Genomic DNA. Translation: AAG23102.1.
AF257581 Genomic DNA. Translation: AAG23105.1.
AF257582 Genomic DNA. Translation: AAG23106.1.
AF257583 Genomic DNA. Translation: AAG23107.1.
AF257585 Genomic DNA. Translation: AAG23109.1.
AF257587 Genomic DNA. Translation: AAG23111.1.
AF257588 Genomic DNA. Translation: AAG23112.1.
AF257589 Genomic DNA. Translation: AAG23113.1.
AY070657 mRNA. Translation: AAL48128.1.
AY071719 mRNA. Translation: AAL49341.1.
AJ309864 Genomic DNA. Translation: CAC34564.1.
RefSeqiNP_524674.1. NM_079935.4.
UniGeneiDm.1873.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087399; FBpp0086530; FBgn0001187.
GeneIDi44008.
KEGGidme:Dmel_CG8094.
UCSCiCG8094-RA. d. melanogaster.

Organism-specific databases

CTDi44008.
FlyBaseiFBgn0001187. Hex-C.

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
KOiK00844.
OMAiCLAKFVE.
OrthoDBiEOG7S21X5.

Enzyme and pathway databases

ReactomeiREACT_307214. Regulation of gene expression in beta cells.
REACT_319845. Glycolysis.
REACT_340255. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_342895. Glucose transport.

Miscellaneous databases

GenomeRNAii44008.
NextBioi836583.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
    Duvernell D.D., Eanes W.F.
    Genetics 156:1191-1201(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HFL97e2_15Imported, HFL97e2_23Imported, HFL97e2_4Imported, HFL97e2_43Imported, HFL97e2_52Imported, HFL97e2_61Imported, HFL97e2_76Imported, MA96e2_28.3Imported, MA96e2_3.5Imported, MA96e2_31.3Imported, MA96e2_42.1Imported, MA96e2_45.5Imported, MA96e2_50.4Imported, MA96e2_7.1Imported, VT97e2_1Imported, VT97e2_19Imported, VT97e2_24Imported, VT97e2_44Imported, VT97e2_59Imported, VT97e2_7Imported, VT97e2_9Imported and ZIMImported.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Lee S.H., Yang E.S., Kim-Ha J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeadImported.
  4. Deobagkar D.N.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-KImported.
  5. Kulkarni G.V., Deobagkar D.D.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-KImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  9. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  16. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7JYW9_DROME
AccessioniPrimary (citable) accession number: Q7JYW9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 24, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.