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Q7JYW9

- Q7JYW9_DROME

UniProt

Q7JYW9 - Q7JYW9_DROME

Protein
Submitted name:

Hexokinase C

Gene

Hex-C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: RefGenome
    3. glucokinase activity Source: RefGenome
    4. hexokinase activity Source: FlyBase
    5. mannokinase activity Source: RefGenome

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. cellular glucose homeostasis Source: RefGenome
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: RefGenome
    5. lateral inhibition Source: FlyBase

    Keywords - Molecular functioni

    KinaseSAAS annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_218382. Glucose transport.
    REACT_80959. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hexokinase CImported (EC:2.7.1.1Imported)
    Submitted name:
    Hexokinase-CImported (EC:2.7.1.1Imported)
    Submitted name:
    RH04305pImported
    Submitted name:
    RH33703pImported
    Gene namesi
    Name:Hex-CImported
    ORF Names:CG8094Imported, Dmel_CG8094Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0001187. Hex-C.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hexokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5026.
    GeneTreeiENSGT00390000017159.
    InParanoidiQ7JYW9.
    KOiK00844.
    OMAiRNADCRV.
    OrthoDBiEOG7S21X5.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.

    Sequencei

    Sequence statusi: Complete.

    Q7JYW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDAEVRELM QPFVLSDYQV QEVYSRFCLE VARGLKRSTH PQANVKCFPT    50
    YVQDLPTGDE MGKYLALDLG GTNFRVLLVS LKGHHDATVD SQIYAVPKDL 100
    MVGPGVDLFD HIAGCLAKFV EKHDMKTAYL PLGFTFSFPC VQLGLKEGIL 150
    VRWTKGFDCA GVEGEDVGRM LHEAIQRRGD ADIAVVAILN DTTGTLMSCA 200
    HRNADCRVGV IVGTGCNACY VEDVENVDLL RADFKKTKRS VIVNAEWGAF 250
    GEGGQLDFVR TEYDREVDEK SLNRSEQLFE KMTAGMYLGN LVRLVLLRAL 300
    ERKLIFKQSS RRPEFASVLQ RNEEVFETRY ISEIEDDSFP EFASTRKIVK 350
    NLFGLEKASV EDCQTLRYIC ECVAKRAATL VAIGVSGLVN RTSNRRVIVG 400
    MDGSVYRYHP KFDAYMRQTL QKLVKADKEW DIMLSEDGSG RGAALVAAVA 450
    SKTK 454
    Length:454
    Mass (Da):50,738
    Last modified:October 3, 2006 - v1
    Checksum:i57B3E6254F63710F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF58160.1.
    AF237469 mRNA. Translation: AAG10690.1.
    AF257540 Genomic DNA. Translation: AAG23064.1.
    AF257541 Genomic DNA. Translation: AAG23065.1.
    AF257543 Genomic DNA. Translation: AAG23067.1.
    AF257546 Genomic DNA. Translation: AAG23070.1.
    AF257547 Genomic DNA. Translation: AAG23071.1.
    AF257549 Genomic DNA. Translation: AAG23073.1.
    AF257551 Genomic DNA. Translation: AAG23075.1.
    AF257554 Genomic DNA. Translation: AAG23078.1.
    AF257555 Genomic DNA. Translation: AAG23079.1.
    AF257558 Genomic DNA. Translation: AAG23082.1.
    AF257561 Genomic DNA. Translation: AAG23085.1.
    AF257564 Genomic DNA. Translation: AAG23088.1.
    AF257565 Genomic DNA. Translation: AAG23089.1.
    AF257567 Genomic DNA. Translation: AAG23091.1.
    AF257568 Genomic DNA. Translation: AAG23092.1.
    AF257570 Genomic DNA. Translation: AAG23094.1.
    AF257571 Genomic DNA. Translation: AAG23095.1.
    AF257573 Genomic DNA. Translation: AAG23097.1.
    AF257574 Genomic DNA. Translation: AAG23098.1.
    AF257575 Genomic DNA. Translation: AAG23099.1.
    AF257576 Genomic DNA. Translation: AAG23100.1.
    AF257577 Genomic DNA. Translation: AAG23101.1.
    AF257578 Genomic DNA. Translation: AAG23102.1.
    AF257581 Genomic DNA. Translation: AAG23105.1.
    AF257582 Genomic DNA. Translation: AAG23106.1.
    AF257583 Genomic DNA. Translation: AAG23107.1.
    AF257585 Genomic DNA. Translation: AAG23109.1.
    AF257587 Genomic DNA. Translation: AAG23111.1.
    AF257588 Genomic DNA. Translation: AAG23112.1.
    AF257589 Genomic DNA. Translation: AAG23113.1.
    AY070657 mRNA. Translation: AAL48128.1.
    AY071719 mRNA. Translation: AAL49341.1.
    AJ309864 Genomic DNA. Translation: CAC34564.1.
    RefSeqiNP_524674.1. NM_079935.3.
    UniGeneiDm.1873.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087399; FBpp0086530; FBgn0001187.
    GeneIDi44008.
    KEGGidme:Dmel_CG8094.
    UCSCiCG8094-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF58160.1 .
    AF237469 mRNA. Translation: AAG10690.1 .
    AF257540 Genomic DNA. Translation: AAG23064.1 .
    AF257541 Genomic DNA. Translation: AAG23065.1 .
    AF257543 Genomic DNA. Translation: AAG23067.1 .
    AF257546 Genomic DNA. Translation: AAG23070.1 .
    AF257547 Genomic DNA. Translation: AAG23071.1 .
    AF257549 Genomic DNA. Translation: AAG23073.1 .
    AF257551 Genomic DNA. Translation: AAG23075.1 .
    AF257554 Genomic DNA. Translation: AAG23078.1 .
    AF257555 Genomic DNA. Translation: AAG23079.1 .
    AF257558 Genomic DNA. Translation: AAG23082.1 .
    AF257561 Genomic DNA. Translation: AAG23085.1 .
    AF257564 Genomic DNA. Translation: AAG23088.1 .
    AF257565 Genomic DNA. Translation: AAG23089.1 .
    AF257567 Genomic DNA. Translation: AAG23091.1 .
    AF257568 Genomic DNA. Translation: AAG23092.1 .
    AF257570 Genomic DNA. Translation: AAG23094.1 .
    AF257571 Genomic DNA. Translation: AAG23095.1 .
    AF257573 Genomic DNA. Translation: AAG23097.1 .
    AF257574 Genomic DNA. Translation: AAG23098.1 .
    AF257575 Genomic DNA. Translation: AAG23099.1 .
    AF257576 Genomic DNA. Translation: AAG23100.1 .
    AF257577 Genomic DNA. Translation: AAG23101.1 .
    AF257578 Genomic DNA. Translation: AAG23102.1 .
    AF257581 Genomic DNA. Translation: AAG23105.1 .
    AF257582 Genomic DNA. Translation: AAG23106.1 .
    AF257583 Genomic DNA. Translation: AAG23107.1 .
    AF257585 Genomic DNA. Translation: AAG23109.1 .
    AF257587 Genomic DNA. Translation: AAG23111.1 .
    AF257588 Genomic DNA. Translation: AAG23112.1 .
    AF257589 Genomic DNA. Translation: AAG23113.1 .
    AY070657 mRNA. Translation: AAL48128.1 .
    AY071719 mRNA. Translation: AAL49341.1 .
    AJ309864 Genomic DNA. Translation: CAC34564.1 .
    RefSeqi NP_524674.1. NM_079935.3.
    UniGenei Dm.1873.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087399 ; FBpp0086530 ; FBgn0001187 .
    GeneIDi 44008.
    KEGGi dme:Dmel_CG8094.
    UCSCi CG8094-RA. d. melanogaster.

    Organism-specific databases

    CTDi 44008.
    FlyBasei FBgn0001187. Hex-C.

    Phylogenomic databases

    eggNOGi COG5026.
    GeneTreei ENSGT00390000017159.
    InParanoidi Q7JYW9.
    KOi K00844.
    OMAi RNADCRV.
    OrthoDBi EOG7S21X5.

    Enzyme and pathway databases

    Reactomei REACT_218382. Glucose transport.
    REACT_80959. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Miscellaneous databases

    GenomeRNAii 44008.
    NextBioi 836583.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    ProtoNeti Search...

    Publicationsi

    1. "Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
      Duvernell D.D., Eanes W.F.
      Genetics 156:1191-1201(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HFL97e2_15Imported, HFL97e2_23Imported, HFL97e2_4Imported, HFL97e2_43Imported, HFL97e2_52Imported, HFL97e2_61Imported, HFL97e2_76Imported, MA96e2_28.3Imported, MA96e2_3.5Imported, MA96e2_31.3Imported, MA96e2_42.1Imported, MA96e2_45.5Imported, MA96e2_50.4Imported, MA96e2_7.1Imported, VT97e2_1Imported, VT97e2_19Imported, VT97e2_24Imported, VT97e2_44Imported, VT97e2_59Imported, VT97e2_7Imported, VT97e2_9Imported and ZIMImported.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Lee S.H., Yang E.S., Kim-Ha J.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeadImported.
    4. Deobagkar D.N.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Oregon-KImported.
    5. Kulkarni G.V., Deobagkar D.D.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Oregon-KImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    9. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    10. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    12. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    13. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    14. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    16. FlyBase
      Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ7JYW9_DROME
    AccessioniPrimary (citable) accession number: Q7JYW9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3