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Q7JYW9

- Q7JYW9_DROME

UniProt

Q7JYW9 - Q7JYW9_DROME

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Protein
Submitted name:

Hexokinase C

Gene

Hex-C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. hexokinase activity Source: FlyBase
  5. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: RefGenome
  5. lateral inhibition Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_218382. Glucose transport.
REACT_80959. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase CImported (EC:2.7.1.1Imported)
Submitted name:
Hexokinase-CImported (EC:2.7.1.1Imported)
Submitted name:
RH04305pImported
Submitted name:
RH33703pImported
Gene namesi
Name:Hex-CImported
ORF Names:CG8094Imported, Dmel_CG8094Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0001187. Hex-C.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
KOiK00844.
OMAiRNADCRV.
OrthoDBiEOG7S21X5.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

Q7JYW9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDAEVRELM QPFVLSDYQV QEVYSRFCLE VARGLKRSTH PQANVKCFPT
60 70 80 90 100
YVQDLPTGDE MGKYLALDLG GTNFRVLLVS LKGHHDATVD SQIYAVPKDL
110 120 130 140 150
MVGPGVDLFD HIAGCLAKFV EKHDMKTAYL PLGFTFSFPC VQLGLKEGIL
160 170 180 190 200
VRWTKGFDCA GVEGEDVGRM LHEAIQRRGD ADIAVVAILN DTTGTLMSCA
210 220 230 240 250
HRNADCRVGV IVGTGCNACY VEDVENVDLL RADFKKTKRS VIVNAEWGAF
260 270 280 290 300
GEGGQLDFVR TEYDREVDEK SLNRSEQLFE KMTAGMYLGN LVRLVLLRAL
310 320 330 340 350
ERKLIFKQSS RRPEFASVLQ RNEEVFETRY ISEIEDDSFP EFASTRKIVK
360 370 380 390 400
NLFGLEKASV EDCQTLRYIC ECVAKRAATL VAIGVSGLVN RTSNRRVIVG
410 420 430 440 450
MDGSVYRYHP KFDAYMRQTL QKLVKADKEW DIMLSEDGSG RGAALVAAVA

SKTK
Length:454
Mass (Da):50,738
Last modified:October 3, 2006 - v1
Checksum:i57B3E6254F63710F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF58160.1.
AF237469 mRNA. Translation: AAG10690.1.
AF257540 Genomic DNA. Translation: AAG23064.1.
AF257541 Genomic DNA. Translation: AAG23065.1.
AF257543 Genomic DNA. Translation: AAG23067.1.
AF257546 Genomic DNA. Translation: AAG23070.1.
AF257547 Genomic DNA. Translation: AAG23071.1.
AF257549 Genomic DNA. Translation: AAG23073.1.
AF257551 Genomic DNA. Translation: AAG23075.1.
AF257554 Genomic DNA. Translation: AAG23078.1.
AF257555 Genomic DNA. Translation: AAG23079.1.
AF257558 Genomic DNA. Translation: AAG23082.1.
AF257561 Genomic DNA. Translation: AAG23085.1.
AF257564 Genomic DNA. Translation: AAG23088.1.
AF257565 Genomic DNA. Translation: AAG23089.1.
AF257567 Genomic DNA. Translation: AAG23091.1.
AF257568 Genomic DNA. Translation: AAG23092.1.
AF257570 Genomic DNA. Translation: AAG23094.1.
AF257571 Genomic DNA. Translation: AAG23095.1.
AF257573 Genomic DNA. Translation: AAG23097.1.
AF257574 Genomic DNA. Translation: AAG23098.1.
AF257575 Genomic DNA. Translation: AAG23099.1.
AF257576 Genomic DNA. Translation: AAG23100.1.
AF257577 Genomic DNA. Translation: AAG23101.1.
AF257578 Genomic DNA. Translation: AAG23102.1.
AF257581 Genomic DNA. Translation: AAG23105.1.
AF257582 Genomic DNA. Translation: AAG23106.1.
AF257583 Genomic DNA. Translation: AAG23107.1.
AF257585 Genomic DNA. Translation: AAG23109.1.
AF257587 Genomic DNA. Translation: AAG23111.1.
AF257588 Genomic DNA. Translation: AAG23112.1.
AF257589 Genomic DNA. Translation: AAG23113.1.
AY070657 mRNA. Translation: AAL48128.1.
AY071719 mRNA. Translation: AAL49341.1.
AJ309864 Genomic DNA. Translation: CAC34564.1.
RefSeqiNP_524674.1. NM_079935.4.
UniGeneiDm.1873.

Genome annotation databases

EnsemblMetazoaiFBtr0087399; FBpp0086530; FBgn0001187.
GeneIDi44008.
KEGGidme:Dmel_CG8094.
UCSCiCG8094-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF58160.1 .
AF237469 mRNA. Translation: AAG10690.1 .
AF257540 Genomic DNA. Translation: AAG23064.1 .
AF257541 Genomic DNA. Translation: AAG23065.1 .
AF257543 Genomic DNA. Translation: AAG23067.1 .
AF257546 Genomic DNA. Translation: AAG23070.1 .
AF257547 Genomic DNA. Translation: AAG23071.1 .
AF257549 Genomic DNA. Translation: AAG23073.1 .
AF257551 Genomic DNA. Translation: AAG23075.1 .
AF257554 Genomic DNA. Translation: AAG23078.1 .
AF257555 Genomic DNA. Translation: AAG23079.1 .
AF257558 Genomic DNA. Translation: AAG23082.1 .
AF257561 Genomic DNA. Translation: AAG23085.1 .
AF257564 Genomic DNA. Translation: AAG23088.1 .
AF257565 Genomic DNA. Translation: AAG23089.1 .
AF257567 Genomic DNA. Translation: AAG23091.1 .
AF257568 Genomic DNA. Translation: AAG23092.1 .
AF257570 Genomic DNA. Translation: AAG23094.1 .
AF257571 Genomic DNA. Translation: AAG23095.1 .
AF257573 Genomic DNA. Translation: AAG23097.1 .
AF257574 Genomic DNA. Translation: AAG23098.1 .
AF257575 Genomic DNA. Translation: AAG23099.1 .
AF257576 Genomic DNA. Translation: AAG23100.1 .
AF257577 Genomic DNA. Translation: AAG23101.1 .
AF257578 Genomic DNA. Translation: AAG23102.1 .
AF257581 Genomic DNA. Translation: AAG23105.1 .
AF257582 Genomic DNA. Translation: AAG23106.1 .
AF257583 Genomic DNA. Translation: AAG23107.1 .
AF257585 Genomic DNA. Translation: AAG23109.1 .
AF257587 Genomic DNA. Translation: AAG23111.1 .
AF257588 Genomic DNA. Translation: AAG23112.1 .
AF257589 Genomic DNA. Translation: AAG23113.1 .
AY070657 mRNA. Translation: AAL48128.1 .
AY071719 mRNA. Translation: AAL49341.1 .
AJ309864 Genomic DNA. Translation: CAC34564.1 .
RefSeqi NP_524674.1. NM_079935.4.
UniGenei Dm.1873.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087399 ; FBpp0086530 ; FBgn0001187 .
GeneIDi 44008.
KEGGi dme:Dmel_CG8094.
UCSCi CG8094-RA. d. melanogaster.

Organism-specific databases

CTDi 44008.
FlyBasei FBgn0001187. Hex-C.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
KOi K00844.
OMAi RNADCRV.
OrthoDBi EOG7S21X5.

Enzyme and pathway databases

Reactomei REACT_218382. Glucose transport.
REACT_80959. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

GenomeRNAii 44008.
NextBioi 836583.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
    Duvernell D.D., Eanes W.F.
    Genetics 156:1191-1201(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HFL97e2_15Imported, HFL97e2_23Imported, HFL97e2_4Imported, HFL97e2_43Imported, HFL97e2_52Imported, HFL97e2_61Imported, HFL97e2_76Imported, MA96e2_28.3Imported, MA96e2_3.5Imported, MA96e2_31.3Imported, MA96e2_42.1Imported, MA96e2_45.5Imported, MA96e2_50.4Imported, MA96e2_7.1Imported, VT97e2_1Imported, VT97e2_19Imported, VT97e2_24Imported, VT97e2_44Imported, VT97e2_59Imported, VT97e2_7Imported, VT97e2_9Imported and ZIMImported.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Lee S.H., Yang E.S., Kim-Ha J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeadImported.
  4. Deobagkar D.N.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-KImported.
  5. Kulkarni G.V., Deobagkar D.D.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Oregon-KImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  9. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  16. FlyBase
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7JYW9_DROME
AccessioniPrimary (citable) accession number: Q7JYW9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3