Q7JW03 (Q7JW03_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CG2257 EMBL ADG53169.1

Submitted name:
LD13772p EMBL AAM49879.1
Submitted name:
LD17992p EMBL AAL28785.1
Submitted name:
Ubc-E2H, isoform A EMBL AAF46319.1
EC=6.3.2.19 EMBL AAF46319.1
Submitted name:
Ubc-E2H, isoform B EMBL AAF46318.1
EC=6.3.2.19 EMBL AAF46318.1
Submitted name:
Ubc-E2H, isoform C EMBL AAN09227.1
EC=6.3.2.19 EMBL AAN09227.1

Gene names

Name:	Ubc-E2H EMBL AAM49879.1 FlyBase FBgn0029996
ORF Names:	CG2257 FlyBase FBgn0029996 EMBL ADG53169.1, Dmel_CG2257 EMBL AAF46318.1

Organism

Drosophila melanogaster (Fruit fly) EMBL AAM49879.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family. RuleBase RU004027

Ontologies

Keywords
Biological process	Ubl conjugation pathway SAAS SAAS023313
Ligand	ATP-binding SAAS SAAS023313 Nucleotide-binding
Molecular function	Ligase SAAS SAAS023313 EMBL AAF46318.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7JW03 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 64EAB8ABE3A2E2D4	FASTA	183	20,889
	10 20 30 40 50 60 MSSPSAGKRR MDNDVIKLIE SKHEVTILGG LNEFHVKFFG PTETPYEGGV WKVRVYLPDN 70 80 90 100 110 120 YPFKSPSIGF VNKIYHPNID ESSGTVCLDV INQAWTALYD LSNIFESFLP QLLTYPNPVD 130 140 150 160 170 180 PLNRDAAALY LHEPEEYHRK VADYVQRYAT EDALRAAQQE RESSDSESSM SDYSEDEARD MEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed: 17569856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed: 17569867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Correlated evolution of nearby residues in Drosophilid proteins." Callahan B., Neher R.A., Bachtrog D., Andolfatto P., Shraiman B.I. PLoS Genet. 7:E1001315-E1001315(2011) [PubMed: 21383965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ZS10 EMBL ADG53188.1, ZW104 EMBL ADG53169.1, ZW109 EMBL ADG53170.1, ZW123 EMBL ADG53171.1, ZW133 EMBL ADG53172.1, ZW136 EMBL ADG53173.1, ZW139 EMBL ADG53174.1, ZW141 EMBL ADG53175.1, ZW142 EMBL ADG53176.1, ZW143 EMBL ADG53177.1, ZW144 EMBL ADG53178.1, ZW149 EMBL ADG53179.1, ZW155 EMBL ADG53180.1, ZW164 EMBL ADG53181.1, ZW165 EMBL ADG53182.1, ZW177 EMBL ADG53183.1, ZW184 EMBL ADG53184.1, ZW185 EMBL ADG53185.1, ZW189 EMBL ADG53186.1 and ZW190 EMBL ADG53187.1.
[5]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed: 16110336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[7]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed: 12537574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed: 12537573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[9]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3 (12), RESEARCH0079 (2002) Cited for: NUCLEOTIDE SEQUENCE.
[10]	Drosophila Heterochromatin Genome Project Smith C.D., Shu S., Mungall C.J., Karpen G.H. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[11]	FlyBase Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL28785.1.
[13]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAM49879.1.
[14]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[15]	Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Karpen G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[16]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF46318.1. AE014298 Genomic DNA. Translation: AAF46319.1. AY061237 mRNA. Translation: AAL28785.1. AY118510 mRNA. Translation: AAM49879.1. AE014298 Genomic DNA. Translation: AAN09227.1. GQ306696 Genomic DNA. Translation: ADG53169.1. GQ306697 Genomic DNA. Translation: ADG53170.1. GQ306698 Genomic DNA. Translation: ADG53171.1. GQ306699 Genomic DNA. Translation: ADG53172.1. GQ306700 Genomic DNA. Translation: ADG53173.1. GQ306701 Genomic DNA. Translation: ADG53174.1. GQ306702 Genomic DNA. Translation: ADG53175.1. GQ306703 Genomic DNA. Translation: ADG53176.1. GQ306704 Genomic DNA. Translation: ADG53177.1. GQ306705 Genomic DNA. Translation: ADG53178.1. GQ306706 Genomic DNA. Translation: ADG53179.1. GQ306707 Genomic DNA. Translation: ADG53180.1. GQ306708 Genomic DNA. Translation: ADG53181.1. GQ306709 Genomic DNA. Translation: ADG53182.1. GQ306710 Genomic DNA. Translation: ADG53183.1. GQ306711 Genomic DNA. Translation: ADG53184.1. GQ306712 Genomic DNA. Translation: ADG53185.1. GQ306713 Genomic DNA. Translation: ADG53186.1. GQ306714 Genomic DNA. Translation: ADG53187.1. GQ306715 Genomic DNA. Translation: ADG53188.1.
RefSeq	NP_572438.1. NM_132210.2. NP_727233.1. NM_167145.1. NP_727234.1. NM_167146.1.
UniGene	Dm.7218.
3D structure databases
HSSP	HSSP built from PDB template 1JBB based on UniProtKB P52490.
ProteinModelPortal	Q7JW03.
SMR	Q7JW03. Positions 4-155.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7JW03. 3 interactions.
MINT	MINT-7761166.
STRING	Q7JW03.
Proteomic databases
PRIDE	Q7JW03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0071112; FBpp0071067; FBgn0029996. FBtr0071113; FBpp0071068; FBgn0029996. FBtr0071114; FBpp0071069; FBgn0029996.
GeneID	31728.
KEGG	dme:Dmel_CG2257.
UCSC	CG2257-RA. d. melanogaster.
Organism-specific databases
CTD	31728.
FlyBase	FBgn0029996. Ubc-E2H.
Phylogenomic databases
GeneTree	EMGT00050000007020.
InParanoid	Q7JW03.
OMA	AGKRRMD.
PhylomeDB	Q7JW03.
Gene expression databases
ArrayExpress	Q7JW03.
Bgee	Q7JW03.
Family and domain databases
InterPro	IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
KO	K10576.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	775042.

Entry information

Entry name

Q7JW03_DROME

Accession

Primary (citable) accession number: Q7JW03

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)