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Protein

Annexin

Gene

nex-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: WormBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • heparan sulfate proteoglycan binding Source: WormBase
  • heparin binding Source: WormBase
  • phosphatidylethanolamine binding Source: WormBase
  • phosphatidylserine binding Source: WormBase

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-114608. Platelet degranulation.
R-CEL-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:nex-2Imported
ORF Names:CELE_T07C4.9Imported, T07C4.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07C4.9b; CE35364; WBGene00003589; nex-2.

PTM / Processingi

Proteomic databases

EPDiQ7JMT5.
PaxDbiQ7JMT5.
PeptideAtlasiQ7JMT5.

Expressioni

Gene expression databases

BgeeiWBGene00003589.
ExpressionAtlasiQ7JMT5. baseline.

Interactioni

GO - Molecular functioni

  • heparan sulfate proteoglycan binding Source: WormBase

Structurei

3D structure databases

ProteinModelPortaliQ7JMT5.
SMRiQ7JMT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7JMT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGGGYPNQ QPSYGGYGQP PQQPGYGNGS YDPYGQPQQQ PYPGGGGQPP
60 70 80 90 100
YPGSNSNQGG GGYPGQGGAP YPGGSGGYPQ APQYGFSGGQ GSAPQPNQGG
110 120 130 140 150
YPPQQQQYPP QQGYQQGGQQ QGGGGFFPNQ GYGQPVMIGT PSVFPVQGFN
160 170 180 190 200
SNADAEVLRK AMKGLGCNNS KVISILCQRT NWQRQEISKA FKVMYGKDLI
210 220 230 240 250
KELKGELHGD FEDLILALMD APAIYDAKQL HRAMEGLGTK ESVLIEIMTS
260 270 280 290 300
RTNAQIQQVR DAYKMLFKKD LERDLIGETS GHFKRLLVSL CAGGRDESSQ
310 320 330 340 350
TDGLRANQDA RRLLQAGEKR LGTDESTFNA ILASQNFSQL RLVFEEYQKA
360 370 380 390 400
SNHSIEKAIE FEFSGDIRDG LLAVIAVIRN RPAYFAKLLH DSMKGLGTRD
410 420 430 440 450
NDLIRLCVTR AEYDMGDIRN MFQSLYRTSL ENMIKGDCSG AYKEGLIALV

NGNRG
Length:455
Mass (Da):49,445
Last modified:July 5, 2004 - v1
Checksum:i6EC74CD1CC442543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAE45742.1.
RefSeqiNP_001022756.1. NM_001027585.3.
UniGeneiCel.32947.

Genome annotation databases

EnsemblMetazoaiT07C4.9b.1; T07C4.9b.1; WBGene00003589.
T07C4.9b.2; T07C4.9b.2; WBGene00003589.
GeneIDi176446.

Similar proteinsi

Entry informationi

Entry nameiQ7JMT5_CAEEL
AccessioniPrimary (citable) accession number: Q7JMT5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported