aqp-2

Functionⁱ

GO - Molecular functionⁱ

water channel activity
Source: WormBase
Inferred from direct assayⁱ
- 17229810

Complete GO annotation...

GO - Biological processⁱ

water transport
Source: WormBase
Inferred from direct assayⁱ
- 17229810

Complete GO annotation...

Keywordsⁱ

Biological process	TransportUniRule annotation

Biological process

TransportUniRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins. R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins. R-CEL-432047. Passive transport by Aquaporins.

Reactomeⁱ

R-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: AQuaPorin or aquaglyceroporin relatedImported
Gene namesⁱ	Name:aqp-2Imported ORF Names:C01G6.1Imported, CELE_C01G6.1Imported
Organismⁱ	Caenorhabditis elegansImported
Taxonomic identifierⁱ	6239 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
Proteomesⁱ	UP000001940 Componentⁱ: Chromosome II

Organism-specific databases

WormBase More...WormBaseⁱ	C01G6.1b; CE19664; WBGene00000170; aqp-2.

WormBaseⁱ

C01G6.1b; CE19664; WBGene00000170; aqp-2.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	20 – 39	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	51 – 72	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	93 – 118	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	152 – 171	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	183 – 202	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	233 – 254	HelicalSequence analysisAdd BLAST	22

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

EPDⁱ	Q7JMQ6.
PaxDbⁱ	Q7JMQ6.
PeptideAtlas More...PeptideAtlasⁱ	Q7JMQ6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	WBGene00000170.
ExpressionAtlasⁱ	Q7JMQ6. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7JMQ6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0224. Eukaryota. COG0580. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046311.
HOGENOMⁱ	HOG000288287.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00333. MIP. 1 hit.
Gene3Dⁱ	1.20.1080.10. 1 hit.
InterProⁱ	View protein in InterPro IPR023271. Aquaporin-like. IPR000425. MIP. IPR022357. MIP_CS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00230. MIP. 1 hit.
PRINTSⁱ	PR00783. MINTRINSICP.
SUPFAMⁱ	SSF81338. SSF81338. 1 hit.
TIGRFAMsⁱ	TIGR00861. MIP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00221. MIP. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7JMQ6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MILDKLRAKF HIRKELLRAV LAEFTGTYLL CLIGLSVVAQ KVLPRPEVNE 
        60         70         80         90        100
FIGVNVGFGI AIVFGVAVSA KLSGGHINPA VSFAFLSVGQ ITIVQFIAYF 
       110        120        130        140        150
VAQFFGAFFG AATVYAVYND AINVFDGGVR TVGGPKDTAG IFASYPAPHL 
       160        170        180        190        200
GLVNGFVDQF VATAVFVFLI AHIVDKRNSY PTWLQPILVG TGFVAIGAAF 
       210        220        230        240        250
GYNCGYPVNP ARDFAPRLFT SIFYGGAVFT KWFWVPIVGP FVGAVVGIWL 
       260        270        280 
YYFLIGFHTP QDAEEKYVVL TGNQELKPLT AKESA

Length:285

Mass (Da):30,868

Last modified:July 5, 2004 - v1

Checksum:ⁱ7FC8804D68229049

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX284602 Genomic DNA. Translation: CAA84642.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_495973.1. NM_063572.3.
UniGeneⁱ	Cel.17495.

Genome annotation databases

EnsemblMetazoaⁱ	C01G6.1b.1; C01G6.1b.1; WBGene00000170. C01G6.1b.2; C01G6.1b.2; WBGene00000170. C01G6.1b.3; C01G6.1b.3; WBGene00000170.
GeneIDⁱ	174467.
UCSC genome browser More...UCSCⁱ	C01G6.1a.2. c. elegans.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q7JMQ6	Q17571 A8WPB6 A0A1I7V198 A0A1I7V197 G0NE95 E3N386	Caenorhabditis elegans Caenorhabditis briggsae Caenorhabditis tropicalis Caenorhabditis brenneri (Nematode worm) Caenorhabditis remanei (Caenorhabditis vulgaris)	290	UniRef90_Q17571	Cluster: AQuaPorin or aquaglyceroporin related	7

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q7JMQ6	Q17571 G0NE95 A8WPB6 A0A1I7V198 A0A1I7V197 E3N386 A0A0R3PKT8 A0A0D8Y6K4 A0A016SGI9 A0A183CFJ1 +12	Caenorhabditis elegans Caenorhabditis brenneri (Nematode worm) Caenorhabditis briggsae Caenorhabditis tropicalis Caenorhabditis remanei (Caenorhabditis vulgaris) Angiostrongylus costaricensis (Nematode worm) Dictyocaulus viviparus (Bovine lungworm) Ancylostoma ceylanicum Globodera pallida (Potato cyst nematode) Heligmosomoides polygyrus bakeri (Parasitic nematode) (Heligmosomoides bakeri) And more	290	UniRef50_Q17571	Cluster: AQuaPorin or aquaglyceroporin related	23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX284602 Genomic DNA. Translation: CAA84642.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_495973.1. NM_063572.3.
UniGeneⁱ	Cel.17495.

3D structure databases

ProteinModelPortalⁱ	Q7JMQ6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	Q7JMQ6.
PaxDbⁱ	Q7JMQ6.
PeptideAtlas More...PeptideAtlasⁱ	Q7JMQ6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	C01G6.1b.1; C01G6.1b.1; WBGene00000170. C01G6.1b.2; C01G6.1b.2; WBGene00000170. C01G6.1b.3; C01G6.1b.3; WBGene00000170.
GeneIDⁱ	174467.
UCSC genome browser More...UCSCⁱ	C01G6.1a.2. c. elegans.

Organism-specific databases

CTDⁱ	174467.
WormBase More...WormBaseⁱ	C01G6.1b; CE19664; WBGene00000170; aqp-2.

Phylogenomic databases

eggNOGⁱ	KOG0224. Eukaryota. COG0580. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046311.
HOGENOMⁱ	HOG000288287.

Enzyme and pathway databases

Reactomeⁱ	R-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins. R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins. R-CEL-432047. Passive transport by Aquaporins.

Reactomeⁱ

R-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Gene expression databases

Bgeeⁱ	WBGene00000170.
ExpressionAtlasⁱ	Q7JMQ6. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00333. MIP. 1 hit.
Gene3Dⁱ	1.20.1080.10. 1 hit.
InterProⁱ	View protein in InterPro IPR023271. Aquaporin-like. IPR000425. MIP. IPR022357. MIP_CS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00230. MIP. 1 hit.
PRINTSⁱ	PR00783. MINTRINSICP.
SUPFAMⁱ	SSF81338. SSF81338. 1 hit.
TIGRFAMsⁱ	TIGR00861. MIP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00221. MIP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q7JMQ6_CAEEL
Accessionⁱ	Q7JMQ6Primary (citable) accession number: Q7JMQ6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	August 30, 2017
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7JMQ6 (Q7JMQ6_CAEEL)

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AQuaPorin or aquaglyceroporin related

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ