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Protein
Submitted name:

AQuaPorin or aquaglyceroporin related

Gene

aqp-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • water channel activity Source: WormBase

GO - Biological processi

  • water transport Source: WormBase
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Submitted name:
AQuaPorin or aquaglyceroporin relatedImported
Gene namesi
Name:aqp-2Imported
ORF Names:C01G6.1Imported, CELE_C01G6.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC01G6.1b; CE19664; WBGene00000170; aqp-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalSequence analysisAdd BLAST20
Transmembranei51 – 72HelicalSequence analysisAdd BLAST22
Transmembranei93 – 118HelicalSequence analysisAdd BLAST26
Transmembranei152 – 171HelicalSequence analysisAdd BLAST20
Transmembranei183 – 202HelicalSequence analysisAdd BLAST20
Transmembranei233 – 254HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ7JMQ6.
PaxDbiQ7JMQ6.
PeptideAtlasiQ7JMQ6.

Expressioni

Gene expression databases

BgeeiWBGene00000170.
ExpressionAtlasiQ7JMQ6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.C01G6.1a.1.

Structurei

3D structure databases

ProteinModelPortaliQ7JMQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7JMQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILDKLRAKF HIRKELLRAV LAEFTGTYLL CLIGLSVVAQ KVLPRPEVNE
60 70 80 90 100
FIGVNVGFGI AIVFGVAVSA KLSGGHINPA VSFAFLSVGQ ITIVQFIAYF
110 120 130 140 150
VAQFFGAFFG AATVYAVYND AINVFDGGVR TVGGPKDTAG IFASYPAPHL
160 170 180 190 200
GLVNGFVDQF VATAVFVFLI AHIVDKRNSY PTWLQPILVG TGFVAIGAAF
210 220 230 240 250
GYNCGYPVNP ARDFAPRLFT SIFYGGAVFT KWFWVPIVGP FVGAVVGIWL
260 270 280
YYFLIGFHTP QDAEEKYVVL TGNQELKPLT AKESA
Length:285
Mass (Da):30,868
Last modified:July 5, 2004 - v1
Checksum:i7FC8804D68229049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA84642.1.
RefSeqiNP_495973.1. NM_063572.3.
UniGeneiCel.17495.

Genome annotation databases

EnsemblMetazoaiC01G6.1b.1; C01G6.1b.1; WBGene00000170.
C01G6.1b.2; C01G6.1b.2; WBGene00000170.
C01G6.1b.3; C01G6.1b.3; WBGene00000170.
GeneIDi174467.
UCSCiC01G6.1a.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA84642.1.
RefSeqiNP_495973.1. NM_063572.3.
UniGeneiCel.17495.

3D structure databases

ProteinModelPortaliQ7JMQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C01G6.1a.1.

Proteomic databases

EPDiQ7JMQ6.
PaxDbiQ7JMQ6.
PeptideAtlasiQ7JMQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC01G6.1b.1; C01G6.1b.1; WBGene00000170.
C01G6.1b.2; C01G6.1b.2; WBGene00000170.
C01G6.1b.3; C01G6.1b.3; WBGene00000170.
GeneIDi174467.
UCSCiC01G6.1a.2. c. elegans.

Organism-specific databases

CTDi174467.
WormBaseiC01G6.1b; CE19664; WBGene00000170; aqp-2.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Gene expression databases

BgeeiWBGene00000170.
ExpressionAtlasiQ7JMQ6. baseline and differential.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7JMQ6_CAEEL
AccessioniPrimary (citable) accession number: Q7JMQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.