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Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

usp-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cleaves ubiquitin fusion protein substrates.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021NucleophilePROSITE-ProRule annotation
Active sitei442 – 4421Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: GO_Central
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: GO_Central

GO - Biological processi

  1. hemidesmosome assembly Source: WormBase
  2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  3. protein deubiquitination Source: UniProtKB
  4. regulation of proteasomal protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ7JKC3.

Protein family/group databases

MEROPSiC19.A54.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:usp-7
Synonyms:math-33
ORF Names:H19N07.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiH19N07.2c; CE36180; WBGene00010406; math-33.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11351135Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268010Add
BLAST

Post-translational modificationi

Polyneddylated.By similarity
Polyubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ7JKC3.
PRIDEiQ7JKC3.

Expressioni

Gene expression databases

ExpressionAtlasiQ7JKC3. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ7JKC3.
SMRiQ7JKC3. Positions 46-544, 692-1119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 172142MATHPROSITE-ProRule annotationAdd
BLAST
Domaini193 – 503311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOGENOMiHOG000160240.
InParanoidiQ7JKC3.
KOiK11838.
OMAiSELACIV.
PhylomeDBiQ7JKC3.

Family and domain databases

InterProiIPR002083. MATH.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7JKC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQCSPDPEDL LIVPTHDIPS YDESLDPFGP EGHLSLDIDC FSKFMSRSDN
60 70 80 90 100
RIMSKPIIVR GIPWRILAIC RNQQGSRHSM NSRVNRSNFN FGFFLQCNND
110 120 130 140 150
ELLQKRGMWR CYGTAVLEVL NADGPSIQKK IHHSFHNTEV DWGFSNYDQY
160 170 180 190 200
DTLCNPKDGY VVNDTIKLRC RFTADVPTGA NYMWDSKRHT GCIGLRNQGA
210 220 230 240 250
TCYMNSILQS FYFTTGFRRA VYNMDVGTEP NESNIVLAMQ RVFYELQMAS
260 270 280 290 300
EAVETNSLTR AFGWDKLDAF NQHDVQEFCR VLLDNLETKM KGTSEEKSIP
310 320 330 340 350
NLFRGNMKSY IKCLDVDYES SRTESFYDVQ LNVLGMDSLE RAFEAYTTSE
360 370 380 390 400
ILDDENKYDA GDHGLQRAEK GVKFVELPPI LHVQLMRFQY CGVEQKINER
410 420 430 440 450
FSFPEKMNLA SCCELGPMLT EEDCVYSLHA VLVHSGEFHG GHYVTYINVN
460 470 480 490 500
LHESAVDPTS SAKWCKFDDD VVSRTTTDDA IVSNFGGEKT MNSSAYMLVY
510 520 530 540 550
VRDNAIDQFL APIPDSQIPQ SVSRTFEMER LHRNREKKKL EEEQLCMGIV
560 570 580 590 600
LVTPDIVASN HSFDLVDQSI VHDSIPHETV WKHMFTAELY QFVHDRLFEK
610 620 630 640 650
SAMQKIDMFD SDDEARQARR DNLRRIKSKK FNFRLWRMTD SYSLERTTQK
660 670 680 690 700
LTSRLRPSEF IDCKTDTRLD TLLSQDFETI YVEFSNNIER PLCEYDTARD
710 720 730 740 750
LLFFVKYYDT MTDKFTIIGH TMFDCHKRFN LYRSMLCEMI GLPADTELKY
760 770 780 790 800
YMEHAASYLE LVDLTQNYSI GRLVEEQDGG ILVVEKVETS TSTQNAKQKM
810 820 830 840 850
NELFLDVEVE FVQSFYNKKP EEEPFEQFVK RICLDDKLFT VAEEIGARLN
860 870 880 890 900
VDPKKVLIWT RVSGSRFEPF FDDYMLNTCK GLMTRPVHDP RAYKRYRVQY
910 920 930 940 950
AIMPFDIDEI SKHRIQTKLF WQLPNGHVEE LTLFPLKEGT VIDIINEAKR
960 970 980 990 1000
YYPFVEGGSG KFRLLQIGAP PLSNQRVYQI YGENTLISDL DQRTMYKLVS
1010 1020 1030 1040 1050
SQALHCRLEE VPIDELDMSP GEFLCPVVHF DREPTKLFGL SFVIKIRNNE
1060 1070 1080 1090 1100
LMTEVRDRLR RKLNDVSDAD FAKYKFALLS RDKLQLCRTI EFNNGEKVNL
1110 1120 1130
ADMANQTTGV PQVYIGLDHK SPIQHSSEAA IRILN
Length:1,135
Mass (Da):131,597
Last modified:July 5, 2004 - v1
Checksum:iC4B24A58E9EEFAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92835 Genomic DNA. Translation: CAE54910.1.
RefSeqiNP_001024012.1. NM_001028841.3.
UniGeneiCel.17273.

Genome annotation databases

EnsemblMetazoaiH19N07.2c; H19N07.2c; WBGene00010406.
GeneIDi179538.
KEGGicel:CELE_H19N07.2.
UCSCiH19N07.2a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92835 Genomic DNA. Translation: CAE54910.1.
RefSeqiNP_001024012.1. NM_001028841.3.
UniGeneiCel.17273.

3D structure databases

ProteinModelPortaliQ7JKC3.
SMRiQ7JKC3. Positions 46-544, 692-1119.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC19.A54.

Proteomic databases

PaxDbiQ7JKC3.
PRIDEiQ7JKC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH19N07.2c; H19N07.2c; WBGene00010406.
GeneIDi179538.
KEGGicel:CELE_H19N07.2.
UCSCiH19N07.2a. c. elegans.

Organism-specific databases

CTDi179538.
WormBaseiH19N07.2c; CE36180; WBGene00010406; math-33.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOGENOMiHOG000160240.
InParanoidiQ7JKC3.
KOiK11838.
OMAiSELACIV.
PhylomeDBiQ7JKC3.

Enzyme and pathway databases

SignaLinkiQ7JKC3.

Miscellaneous databases

NextBioi905840.
PROiQ7JKC3.

Gene expression databases

ExpressionAtlasiQ7JKC3. baseline.

Family and domain databases

InterProiIPR002083. MATH.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBP7_CAEEL
AccessioniPrimary (citable) accession number: Q7JKC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.