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Q7JKC3

- UBP7_CAEEL

UniProt

Q7JKC3 - UBP7_CAEEL

Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

usp-7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cleaves ubiquitin fusion protein substrates.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei202 – 2021NucleophilePROSITE-ProRule annotation
    Active sitei442 – 4421Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. hemidesmosome assembly Source: WormBase
    2. protein deubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ7JKC3.

    Protein family/group databases

    MEROPSiC19.A54.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 7
    Ubiquitin thioesterase 7
    Ubiquitin-specific-processing protease 7
    Gene namesi
    Name:usp-7
    Synonyms:math-33
    ORF Names:H19N07.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiH19N07.2c; CE36180; WBGene00010406; math-33.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11351135Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268010Add
    BLAST

    Post-translational modificationi

    Polyneddylated.By similarity
    Polyubiquitinated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ7JKC3.
    PRIDEiQ7JKC3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7JKC3.
    SMRiQ7JKC3. Positions 46-544, 692-1119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 172142MATHPROSITE-ProRule annotationAdd
    BLAST
    Domaini193 – 503311USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 MATH domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00740000115066.
    HOGENOMiHOG000160240.
    InParanoidiQ7JKC3.
    KOiK11838.
    OMAiNNELMTE.
    PhylomeDBiQ7JKC3.

    Family and domain databases

    InterProiIPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view]
    PfamiPF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view]
    SMARTiSM00061. MATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 1 hit.
    PROSITEiPS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7JKC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQCSPDPEDL LIVPTHDIPS YDESLDPFGP EGHLSLDIDC FSKFMSRSDN     50
    RIMSKPIIVR GIPWRILAIC RNQQGSRHSM NSRVNRSNFN FGFFLQCNND 100
    ELLQKRGMWR CYGTAVLEVL NADGPSIQKK IHHSFHNTEV DWGFSNYDQY 150
    DTLCNPKDGY VVNDTIKLRC RFTADVPTGA NYMWDSKRHT GCIGLRNQGA 200
    TCYMNSILQS FYFTTGFRRA VYNMDVGTEP NESNIVLAMQ RVFYELQMAS 250
    EAVETNSLTR AFGWDKLDAF NQHDVQEFCR VLLDNLETKM KGTSEEKSIP 300
    NLFRGNMKSY IKCLDVDYES SRTESFYDVQ LNVLGMDSLE RAFEAYTTSE 350
    ILDDENKYDA GDHGLQRAEK GVKFVELPPI LHVQLMRFQY CGVEQKINER 400
    FSFPEKMNLA SCCELGPMLT EEDCVYSLHA VLVHSGEFHG GHYVTYINVN 450
    LHESAVDPTS SAKWCKFDDD VVSRTTTDDA IVSNFGGEKT MNSSAYMLVY 500
    VRDNAIDQFL APIPDSQIPQ SVSRTFEMER LHRNREKKKL EEEQLCMGIV 550
    LVTPDIVASN HSFDLVDQSI VHDSIPHETV WKHMFTAELY QFVHDRLFEK 600
    SAMQKIDMFD SDDEARQARR DNLRRIKSKK FNFRLWRMTD SYSLERTTQK 650
    LTSRLRPSEF IDCKTDTRLD TLLSQDFETI YVEFSNNIER PLCEYDTARD 700
    LLFFVKYYDT MTDKFTIIGH TMFDCHKRFN LYRSMLCEMI GLPADTELKY 750
    YMEHAASYLE LVDLTQNYSI GRLVEEQDGG ILVVEKVETS TSTQNAKQKM 800
    NELFLDVEVE FVQSFYNKKP EEEPFEQFVK RICLDDKLFT VAEEIGARLN 850
    VDPKKVLIWT RVSGSRFEPF FDDYMLNTCK GLMTRPVHDP RAYKRYRVQY 900
    AIMPFDIDEI SKHRIQTKLF WQLPNGHVEE LTLFPLKEGT VIDIINEAKR 950
    YYPFVEGGSG KFRLLQIGAP PLSNQRVYQI YGENTLISDL DQRTMYKLVS 1000
    SQALHCRLEE VPIDELDMSP GEFLCPVVHF DREPTKLFGL SFVIKIRNNE 1050
    LMTEVRDRLR RKLNDVSDAD FAKYKFALLS RDKLQLCRTI EFNNGEKVNL 1100
    ADMANQTTGV PQVYIGLDHK SPIQHSSEAA IRILN 1135
    Length:1,135
    Mass (Da):131,597
    Last modified:July 5, 2004 - v1
    Checksum:iC4B24A58E9EEFAEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z92835 Genomic DNA. Translation: CAE54910.1.
    RefSeqiNP_001024012.1. NM_001028841.3.
    UniGeneiCel.17273.

    Genome annotation databases

    EnsemblMetazoaiH19N07.2c; H19N07.2c; WBGene00010406.
    GeneIDi179538.
    KEGGicel:CELE_H19N07.2.
    UCSCiH19N07.2a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z92835 Genomic DNA. Translation: CAE54910.1 .
    RefSeqi NP_001024012.1. NM_001028841.3.
    UniGenei Cel.17273.

    3D structure databases

    ProteinModelPortali Q7JKC3.
    SMRi Q7JKC3. Positions 46-544, 692-1119.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A54.

    Proteomic databases

    PaxDbi Q7JKC3.
    PRIDEi Q7JKC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai H19N07.2c ; H19N07.2c ; WBGene00010406 .
    GeneIDi 179538.
    KEGGi cel:CELE_H19N07.2.
    UCSCi H19N07.2a. c. elegans.

    Organism-specific databases

    CTDi 179538.
    WormBasei H19N07.2c ; CE36180 ; WBGene00010406 ; math-33.

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00740000115066.
    HOGENOMi HOG000160240.
    InParanoidi Q7JKC3.
    KOi K11838.
    OMAi NNELMTE.
    PhylomeDBi Q7JKC3.

    Enzyme and pathway databases

    SignaLinki Q7JKC3.

    Miscellaneous databases

    NextBioi 905840.
    PROi Q7JKC3.

    Family and domain databases

    InterProi IPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view ]
    Pfami PF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view ]
    SMARTi SM00061. MATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 1 hit.
    PROSITEi PS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUBP7_CAEEL
    AccessioniPrimary (citable) accession number: Q7JKC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3