Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7JKC3 (UBP7_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 7

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene names
Name:usp-7
Synonyms:math-33
ORF Names:H19N07.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1135 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves ubiquitin fusion protein substrates By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Post-translational modification

Polyneddylated By similarity.

Polyubiquitinated By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MATH domain.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11351135Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000268010

Regions

Domain31 – 172142MATH
Domain193 – 503311USP

Sites

Active site2021Nucleophile By similarity
Active site4421Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7JKC3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C4B24A58E9EEFAEB

FASTA1,135131,597
        10         20         30         40         50         60 
MQCSPDPEDL LIVPTHDIPS YDESLDPFGP EGHLSLDIDC FSKFMSRSDN RIMSKPIIVR 

        70         80         90        100        110        120 
GIPWRILAIC RNQQGSRHSM NSRVNRSNFN FGFFLQCNND ELLQKRGMWR CYGTAVLEVL 

       130        140        150        160        170        180 
NADGPSIQKK IHHSFHNTEV DWGFSNYDQY DTLCNPKDGY VVNDTIKLRC RFTADVPTGA 

       190        200        210        220        230        240 
NYMWDSKRHT GCIGLRNQGA TCYMNSILQS FYFTTGFRRA VYNMDVGTEP NESNIVLAMQ 

       250        260        270        280        290        300 
RVFYELQMAS EAVETNSLTR AFGWDKLDAF NQHDVQEFCR VLLDNLETKM KGTSEEKSIP 

       310        320        330        340        350        360 
NLFRGNMKSY IKCLDVDYES SRTESFYDVQ LNVLGMDSLE RAFEAYTTSE ILDDENKYDA 

       370        380        390        400        410        420 
GDHGLQRAEK GVKFVELPPI LHVQLMRFQY CGVEQKINER FSFPEKMNLA SCCELGPMLT 

       430        440        450        460        470        480 
EEDCVYSLHA VLVHSGEFHG GHYVTYINVN LHESAVDPTS SAKWCKFDDD VVSRTTTDDA 

       490        500        510        520        530        540 
IVSNFGGEKT MNSSAYMLVY VRDNAIDQFL APIPDSQIPQ SVSRTFEMER LHRNREKKKL 

       550        560        570        580        590        600 
EEEQLCMGIV LVTPDIVASN HSFDLVDQSI VHDSIPHETV WKHMFTAELY QFVHDRLFEK 

       610        620        630        640        650        660 
SAMQKIDMFD SDDEARQARR DNLRRIKSKK FNFRLWRMTD SYSLERTTQK LTSRLRPSEF 

       670        680        690        700        710        720 
IDCKTDTRLD TLLSQDFETI YVEFSNNIER PLCEYDTARD LLFFVKYYDT MTDKFTIIGH 

       730        740        750        760        770        780 
TMFDCHKRFN LYRSMLCEMI GLPADTELKY YMEHAASYLE LVDLTQNYSI GRLVEEQDGG 

       790        800        810        820        830        840 
ILVVEKVETS TSTQNAKQKM NELFLDVEVE FVQSFYNKKP EEEPFEQFVK RICLDDKLFT 

       850        860        870        880        890        900 
VAEEIGARLN VDPKKVLIWT RVSGSRFEPF FDDYMLNTCK GLMTRPVHDP RAYKRYRVQY 

       910        920        930        940        950        960 
AIMPFDIDEI SKHRIQTKLF WQLPNGHVEE LTLFPLKEGT VIDIINEAKR YYPFVEGGSG 

       970        980        990       1000       1010       1020 
KFRLLQIGAP PLSNQRVYQI YGENTLISDL DQRTMYKLVS SQALHCRLEE VPIDELDMSP 

      1030       1040       1050       1060       1070       1080 
GEFLCPVVHF DREPTKLFGL SFVIKIRNNE LMTEVRDRLR RKLNDVSDAD FAKYKFALLS 

      1090       1100       1110       1120       1130 
RDKLQLCRTI EFNNGEKVNL ADMANQTTGV PQVYIGLDHK SPIQHSSEAA IRILN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z92835 Genomic DNA. Translation: CAE54910.1.
RefSeqNP_001024012.1. NM_001028841.3.
UniGeneCel.17273.

3D structure databases

ProteinModelPortalQ7JKC3.
SMRQ7JKC3. Positions 46-1121.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.A54.

Proteomic databases

PaxDbQ7JKC3.
PRIDEQ7JKC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaH19N07.2c; H19N07.2c; H19N07.2.
GeneID179538.
KEGGcel:CELE_H19N07.2.
UCSCH19N07.2a. c. elegans.

Organism-specific databases

CTD179538.
WormBaseH19N07.2c; CE36180; WBGene00010406; math-33.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000160240.
InParanoidQ7JKC3.
KOK11838.
OMANADGPSI.
PhylomeDBQ7JKC3.

Enzyme and pathway databases

SignaLinkQ7JKC3.

Family and domain databases

InterProIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
[Graphical view]
PfamPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 1 hit.
PROSITEPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio905840.
PROQ7JKC3.

Entry information

Entry nameUBP7_CAEEL
AccessionPrimary (citable) accession number: Q7JKC3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase