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Q7JKC3

- UBP7_CAEEL

UniProt

Q7JKC3 - UBP7_CAEEL

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Protein
Ubiquitin carboxyl-terminal hydrolase 7
Gene
usp-7, math-33, H19N07.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cleaves ubiquitin fusion protein substrates By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021Nucleophile By similarity
Active sitei442 – 4421Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. hemidesmosome assembly Source: WormBase
  2. protein deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ7JKC3.

Protein family/group databases

MEROPSiC19.A54.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:usp-7
Synonyms:math-33
ORF Names:H19N07.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiH19N07.2c; CE36180; WBGene00010406; math-33.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11351135Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000268010Add
BLAST

Post-translational modificationi

Polyneddylated By similarity.
Polyubiquitinated By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ7JKC3.
PRIDEiQ7JKC3.

Structurei

3D structure databases

ProteinModelPortaliQ7JKC3.
SMRiQ7JKC3. Positions 46-544, 692-1119.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 172142MATH
Add
BLAST
Domaini193 – 503311USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 MATH domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00740000115066.
HOGENOMiHOG000160240.
InParanoidiQ7JKC3.
KOiK11838.
OMAiNNELMTE.
PhylomeDBiQ7JKC3.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7JKC3-1 [UniParc]FASTAAdd to Basket

« Hide

MQCSPDPEDL LIVPTHDIPS YDESLDPFGP EGHLSLDIDC FSKFMSRSDN     50
RIMSKPIIVR GIPWRILAIC RNQQGSRHSM NSRVNRSNFN FGFFLQCNND 100
ELLQKRGMWR CYGTAVLEVL NADGPSIQKK IHHSFHNTEV DWGFSNYDQY 150
DTLCNPKDGY VVNDTIKLRC RFTADVPTGA NYMWDSKRHT GCIGLRNQGA 200
TCYMNSILQS FYFTTGFRRA VYNMDVGTEP NESNIVLAMQ RVFYELQMAS 250
EAVETNSLTR AFGWDKLDAF NQHDVQEFCR VLLDNLETKM KGTSEEKSIP 300
NLFRGNMKSY IKCLDVDYES SRTESFYDVQ LNVLGMDSLE RAFEAYTTSE 350
ILDDENKYDA GDHGLQRAEK GVKFVELPPI LHVQLMRFQY CGVEQKINER 400
FSFPEKMNLA SCCELGPMLT EEDCVYSLHA VLVHSGEFHG GHYVTYINVN 450
LHESAVDPTS SAKWCKFDDD VVSRTTTDDA IVSNFGGEKT MNSSAYMLVY 500
VRDNAIDQFL APIPDSQIPQ SVSRTFEMER LHRNREKKKL EEEQLCMGIV 550
LVTPDIVASN HSFDLVDQSI VHDSIPHETV WKHMFTAELY QFVHDRLFEK 600
SAMQKIDMFD SDDEARQARR DNLRRIKSKK FNFRLWRMTD SYSLERTTQK 650
LTSRLRPSEF IDCKTDTRLD TLLSQDFETI YVEFSNNIER PLCEYDTARD 700
LLFFVKYYDT MTDKFTIIGH TMFDCHKRFN LYRSMLCEMI GLPADTELKY 750
YMEHAASYLE LVDLTQNYSI GRLVEEQDGG ILVVEKVETS TSTQNAKQKM 800
NELFLDVEVE FVQSFYNKKP EEEPFEQFVK RICLDDKLFT VAEEIGARLN 850
VDPKKVLIWT RVSGSRFEPF FDDYMLNTCK GLMTRPVHDP RAYKRYRVQY 900
AIMPFDIDEI SKHRIQTKLF WQLPNGHVEE LTLFPLKEGT VIDIINEAKR 950
YYPFVEGGSG KFRLLQIGAP PLSNQRVYQI YGENTLISDL DQRTMYKLVS 1000
SQALHCRLEE VPIDELDMSP GEFLCPVVHF DREPTKLFGL SFVIKIRNNE 1050
LMTEVRDRLR RKLNDVSDAD FAKYKFALLS RDKLQLCRTI EFNNGEKVNL 1100
ADMANQTTGV PQVYIGLDHK SPIQHSSEAA IRILN 1135
Length:1,135
Mass (Da):131,597
Last modified:July 5, 2004 - v1
Checksum:iC4B24A58E9EEFAEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z92835 Genomic DNA. Translation: CAE54910.1.
RefSeqiNP_001024012.1. NM_001028841.3.
UniGeneiCel.17273.

Genome annotation databases

EnsemblMetazoaiH19N07.2c; H19N07.2c; WBGene00010406.
GeneIDi179538.
KEGGicel:CELE_H19N07.2.
UCSCiH19N07.2a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z92835 Genomic DNA. Translation: CAE54910.1 .
RefSeqi NP_001024012.1. NM_001028841.3.
UniGenei Cel.17273.

3D structure databases

ProteinModelPortali Q7JKC3.
SMRi Q7JKC3. Positions 46-544, 692-1119.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.A54.

Proteomic databases

PaxDbi Q7JKC3.
PRIDEi Q7JKC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai H19N07.2c ; H19N07.2c ; WBGene00010406 .
GeneIDi 179538.
KEGGi cel:CELE_H19N07.2.
UCSCi H19N07.2a. c. elegans.

Organism-specific databases

CTDi 179538.
WormBasei H19N07.2c ; CE36180 ; WBGene00010406 ; math-33.

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00740000115066.
HOGENOMi HOG000160240.
InParanoidi Q7JKC3.
KOi K11838.
OMAi NNELMTE.
PhylomeDBi Q7JKC3.

Enzyme and pathway databases

SignaLinki Q7JKC3.

Miscellaneous databases

NextBioi 905840.
PROi Q7JKC3.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBP7_CAEEL
AccessioniPrimary (citable) accession number: Q7JKC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi