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Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

math-33

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolase that deubiquitinates target proteins.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202NucleophilePROSITE-ProRule annotation1
Active sitei442Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • RNA polymerase II sequence-specific DNA binding transcription factor binding Source: WormBase
  • thiol-dependent ubiquitin-specific protease activity Source: WormBase

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: WormBase
  • hemidesmosome assembly Source: WormBase
  • maintenance of centrosome location Source: WormBase
  • positive regulation of DNA binding transcription factor activity Source: WormBase
  • protein deubiquitination Source: WormBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ7JKC3

Protein family/group databases

MEROPSiC19.A54

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:math-33Imported
Synonyms:usp-7Imported
ORF Names:H19N07.2Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiH19N07.2c ; CE36180 ; WBGene00010406 ; math-33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002680101 – 1135Ubiquitin carboxyl-terminal hydrolase 7Add BLAST1135

Proteomic databases

PaxDbiQ7JKC3
PRIDEiQ7JKC3

PTM databases

iPTMnetiQ7JKC3

Expressioni

Gene expression databases

BgeeiWBGene00010406
ExpressionAtlasiQ7JKC3 baseline and differential

Interactioni

GO - Molecular functioni

  • RNA polymerase II sequence-specific DNA binding transcription factor binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.H19N07.2c

Structurei

3D structure databases

ProteinModelPortaliQ7JKC3
SMRiQ7JKC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 172MATHPROSITE-ProRule annotationAdd BLAST142
Domaini193 – 503USPAdd BLAST311

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1863 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00760000119158
HOGENOMiHOG000160240
InParanoidiQ7JKC3
PhylomeDBiQ7JKC3

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR001394 Peptidase_C19_UCH
IPR008974 TRAF-like
IPR024729 USP7_ICP0-binding_dom
IPR029346 USP_C
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00917 MATH, 1 hit
PF00443 UCH, 1 hit
PF14533 USP7_C2, 1 hit
PF12436 USP7_ICP0_bdg, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7JKC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCSPDPEDL LIVPTHDIPS YDESLDPFGP EGHLSLDIDC FSKFMSRSDN
60 70 80 90 100
RIMSKPIIVR GIPWRILAIC RNQQGSRHSM NSRVNRSNFN FGFFLQCNND
110 120 130 140 150
ELLQKRGMWR CYGTAVLEVL NADGPSIQKK IHHSFHNTEV DWGFSNYDQY
160 170 180 190 200
DTLCNPKDGY VVNDTIKLRC RFTADVPTGA NYMWDSKRHT GCIGLRNQGA
210 220 230 240 250
TCYMNSILQS FYFTTGFRRA VYNMDVGTEP NESNIVLAMQ RVFYELQMAS
260 270 280 290 300
EAVETNSLTR AFGWDKLDAF NQHDVQEFCR VLLDNLETKM KGTSEEKSIP
310 320 330 340 350
NLFRGNMKSY IKCLDVDYES SRTESFYDVQ LNVLGMDSLE RAFEAYTTSE
360 370 380 390 400
ILDDENKYDA GDHGLQRAEK GVKFVELPPI LHVQLMRFQY CGVEQKINER
410 420 430 440 450
FSFPEKMNLA SCCELGPMLT EEDCVYSLHA VLVHSGEFHG GHYVTYINVN
460 470 480 490 500
LHESAVDPTS SAKWCKFDDD VVSRTTTDDA IVSNFGGEKT MNSSAYMLVY
510 520 530 540 550
VRDNAIDQFL APIPDSQIPQ SVSRTFEMER LHRNREKKKL EEEQLCMGIV
560 570 580 590 600
LVTPDIVASN HSFDLVDQSI VHDSIPHETV WKHMFTAELY QFVHDRLFEK
610 620 630 640 650
SAMQKIDMFD SDDEARQARR DNLRRIKSKK FNFRLWRMTD SYSLERTTQK
660 670 680 690 700
LTSRLRPSEF IDCKTDTRLD TLLSQDFETI YVEFSNNIER PLCEYDTARD
710 720 730 740 750
LLFFVKYYDT MTDKFTIIGH TMFDCHKRFN LYRSMLCEMI GLPADTELKY
760 770 780 790 800
YMEHAASYLE LVDLTQNYSI GRLVEEQDGG ILVVEKVETS TSTQNAKQKM
810 820 830 840 850
NELFLDVEVE FVQSFYNKKP EEEPFEQFVK RICLDDKLFT VAEEIGARLN
860 870 880 890 900
VDPKKVLIWT RVSGSRFEPF FDDYMLNTCK GLMTRPVHDP RAYKRYRVQY
910 920 930 940 950
AIMPFDIDEI SKHRIQTKLF WQLPNGHVEE LTLFPLKEGT VIDIINEAKR
960 970 980 990 1000
YYPFVEGGSG KFRLLQIGAP PLSNQRVYQI YGENTLISDL DQRTMYKLVS
1010 1020 1030 1040 1050
SQALHCRLEE VPIDELDMSP GEFLCPVVHF DREPTKLFGL SFVIKIRNNE
1060 1070 1080 1090 1100
LMTEVRDRLR RKLNDVSDAD FAKYKFALLS RDKLQLCRTI EFNNGEKVNL
1110 1120 1130
ADMANQTTGV PQVYIGLDHK SPIQHSSEAA IRILN
Length:1,135
Mass (Da):131,597
Last modified:July 5, 2004 - v1
Checksum:iC4B24A58E9EEFAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92835 Genomic DNA Translation: CAE54910.1
RefSeqiNP_001024012.1, NM_001028841.3
UniGeneiCel.17273

Genome annotation databases

EnsemblMetazoaiH19N07.2c; H19N07.2c; WBGene00010406
GeneIDi179538
UCSCiH19N07.2a c. elegans

Similar proteinsi

Entry informationi

Entry nameiUBP7_CAEEL
AccessioniPrimary (citable) accession number: Q7JKC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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