Q7JKC3 (UBP7_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 7
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7

Gene names

Name:	usp-7
Synonyms:	math-33
ORF Names:	H19N07.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1135 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cleaves ubiquitin fusion protein substrates By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subcellular location	Nucleus By similarity.
Post-translational modification	Polyneddylated By similarity. Polyubiquitinated By similarity.
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 MATH domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Hydrolase Protease Thiol protease
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hemidesmosome assembly Inferred from genetic interaction PubMed 20153198. Source: WormBase protein deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay PubMed 23209443. Source: WormBase nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1135	1135	Ubiquitin carboxyl-terminal hydrolase 7		PRO_0000268010
Regions
	Domain	31 – 172	142	MATH
Sites
	Active site	202	1	Nucleophile By similarity
	Active site	442	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7JKC3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C4B24A58E9EEFAEB	FASTA	1,135	131,597
	10 20 30 40 50 60 MQCSPDPEDL LIVPTHDIPS YDESLDPFGP EGHLSLDIDC FSKFMSRSDN RIMSKPIIVR 70 80 90 100 110 120 GIPWRILAIC RNQQGSRHSM NSRVNRSNFN FGFFLQCNND ELLQKRGMWR CYGTAVLEVL 130 140 150 160 170 180 NADGPSIQKK IHHSFHNTEV DWGFSNYDQY DTLCNPKDGY VVNDTIKLRC RFTADVPTGA 190 200 210 220 230 240 NYMWDSKRHT GCIGLRNQGA TCYMNSILQS FYFTTGFRRA VYNMDVGTEP NESNIVLAMQ 250 260 270 280 290 300 RVFYELQMAS EAVETNSLTR AFGWDKLDAF NQHDVQEFCR VLLDNLETKM KGTSEEKSIP 310 320 330 340 350 360 NLFRGNMKSY IKCLDVDYES SRTESFYDVQ LNVLGMDSLE RAFEAYTTSE ILDDENKYDA 370 380 390 400 410 420 GDHGLQRAEK GVKFVELPPI LHVQLMRFQY CGVEQKINER FSFPEKMNLA SCCELGPMLT 430 440 450 460 470 480 EEDCVYSLHA VLVHSGEFHG GHYVTYINVN LHESAVDPTS SAKWCKFDDD VVSRTTTDDA 490 500 510 520 530 540 IVSNFGGEKT MNSSAYMLVY VRDNAIDQFL APIPDSQIPQ SVSRTFEMER LHRNREKKKL 550 560 570 580 590 600 EEEQLCMGIV LVTPDIVASN HSFDLVDQSI VHDSIPHETV WKHMFTAELY QFVHDRLFEK 610 620 630 640 650 660 SAMQKIDMFD SDDEARQARR DNLRRIKSKK FNFRLWRMTD SYSLERTTQK LTSRLRPSEF 670 680 690 700 710 720 IDCKTDTRLD TLLSQDFETI YVEFSNNIER PLCEYDTARD LLFFVKYYDT MTDKFTIIGH 730 740 750 760 770 780 TMFDCHKRFN LYRSMLCEMI GLPADTELKY YMEHAASYLE LVDLTQNYSI GRLVEEQDGG 790 800 810 820 830 840 ILVVEKVETS TSTQNAKQKM NELFLDVEVE FVQSFYNKKP EEEPFEQFVK RICLDDKLFT 850 860 870 880 890 900 VAEEIGARLN VDPKKVLIWT RVSGSRFEPF FDDYMLNTCK GLMTRPVHDP RAYKRYRVQY 910 920 930 940 950 960 AIMPFDIDEI SKHRIQTKLF WQLPNGHVEE LTLFPLKEGT VIDIINEAKR YYPFVEGGSG 970 980 990 1000 1010 1020 KFRLLQIGAP PLSNQRVYQI YGENTLISDL DQRTMYKLVS SQALHCRLEE VPIDELDMSP 1030 1040 1050 1060 1070 1080 GEFLCPVVHF DREPTKLFGL SFVIKIRNNE LMTEVRDRLR RKLNDVSDAD FAKYKFALLS 1090 1100 1110 1120 1130 RDKLQLCRTI EFNNGEKVNL ADMANQTTGV PQVYIGLDHK SPIQHSSEAA IRILN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z92835 Genomic DNA. Translation: CAE54910.1.
RefSeq	NP_001024012.1. NM_001028841.3.
UniGene	Cel.17273.
3D structure databases
ProteinModelPortal	Q7JKC3.
SMR	Q7JKC3. Positions 46-544, 692-1119.
ModBase	Search...
Protein family/group databases
MEROPS	C19.A54.
Proteomic databases
PaxDb	Q7JKC3.
PRIDE	Q7JKC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	H19N07.2c; H19N07.2c; H19N07.2.
GeneID	179538.
KEGG	cel:CELE_H19N07.2.
UCSC	H19N07.2a. c. elegans.
Organism-specific databases
CTD	179538.
WormBase	H19N07.2c; CE36180; WBGene00010406; math-33.
Phylogenomic databases
eggNOG	COG5077.
GeneTree	ENSGT00630000089581.
HOGENOM	HOG000160240.
InParanoid	Q7JKC3.
KO	K11838.
OMA	ERAFEAY.
Enzyme and pathway databases
SignaLink	Q7JKC3.
Gene expression databases
ArrayExpress	Q7JKC3.
Family and domain databases
InterPro	IPR002083. MATH. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR008974. TRAF-like. [Graphical view]
Pfam	PF00917. MATH. 1 hit. PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00061. MATH. 1 hit. [Graphical view]
SUPFAM	SSF49599. Traf_like. 1 hit.
PROSITE	PS50144. MATH. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	905840.

Entry information

Entry name

UBP7_CAEEL

Accession

Primary (citable) accession number: Q7JKC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project