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Protein

Bromodomain-containing protein 2

Gene

Brd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 2
Alternative name(s):
Female sterile homeotic-related protein 1
Fsrg-1
Protein RING3
Gene namesi
Name:Brd2
Synonyms:Fsrg1, Kiaa4005, Ring3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99495 Brd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740051 – 798Bromodomain-containing protein 2Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6PhosphothreonineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei297PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei631PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7JJ13
PaxDbiQ7JJ13
PeptideAtlasiQ7JJ13
PRIDEiQ7JJ13

PTM databases

iPTMnetiQ7JJ13
PhosphoSitePlusiQ7JJ13

Expressioni

Tissue specificityi

Predominantly expressed in the testis, followed by ovary, placenta, embryo and to a lower extent in somatic tissues.2 Publications

Gene expression databases

BgeeiENSMUSG00000024335
CleanExiMM_BRD2
ExpressionAtlasiQ7JJ13 baseline and differential
GenevisibleiQ7JJ13 MM

Interactioni

Subunit structurei

Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199750, 1 interactor
IntActiQ7JJ13, 1 interactor
MINTiQ7JJ13
STRINGi10090.ENSMUSP00000025193

Structurei

3D structure databases

ProteinModelPortaliQ7JJ13
SMRiQ7JJ13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 162Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini363 – 435Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini630 – 712NETPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi553 – 557Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Pro4
Compositional biasi228 – 331Pro-richAdd BLAST104
Compositional biasi478 – 523Glu-richAdd BLAST46
Compositional biasi549 – 557Poly-Lys9
Compositional biasi589 – 592Poly-Gly4
Compositional biasi632 – 636Poly-Glu5
Compositional biasi761 – 797Ser-richAdd BLAST37

Domaini

One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.By similarity

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG1474 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00760000119206
HOVERGENiHBG004896
InParanoidiQ7JJ13
KOiK08871
OMAiPTGYDSE
OrthoDBiEOG091G01QC
PhylomeDBiQ7JJ13
TreeFamiTF317345

Family and domain databases

Gene3Di1.20.1270.220, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027353 NET_dom
IPR038336 NET_sf
PfamiView protein in Pfam
PF17035 BET, 1 hit
PF00439 Bromodomain, 2 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
PS51525 NET, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7JJ13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQNVTPHKL PGEGNAGLLG LGPEAAAPGK RIRKPSLLYE GFESPTMASV
60 70 80 90 100
PALQLAPANP PPPEVSNPKK PGRVTNQLQY LHKVVMKALW KHQFAWPFRQ
110 120 130 140 150
PVDAVKLGLP DYHKIIKQPM DMGTIKRRLE NNYYWAASEC MQDFNTMFTN
160 170 180 190 200
CYIYNKPTDD IVLMAQTLEK IFLQKVASMP QEEQELVVTI PKNSHKKGAK
210 220 230 240 250
LAALQGSITS AHQVPAVSSV SHTALYTPPP EIPTTVLNIP HPSVISSPLL
260 270 280 290 300
KSLHSAGPPL LAVSAAPPAQ PLAKKKGVKR KADTTTPTPT AILAPGSPAS
310 320 330 340 350
PPGSLEPKAA RLPPMRRESG RPIKPPRKDL PDSQQQHQSS KKGKLSEQLK
360 370 380 390 400
HCNGILKELL SKKHAAYAWP FYKPVDASAL GLHDYHDIIK HPMDLSTVKR
410 420 430 440 450
KMENRDYRDA QEFAADVRLM FSNCYKYNPP DHDVVAMARK LQDVFEFRYA
460 470 480 490 500
KMPDEPLEPG PLPVSTALPP GLTKSSSESS SEESSSESSS EEEEEEEEDE
510 520 530 540 550
DEEESESSDS EEERAHRLAE LQEQLRAVHE QLAALSQGPI SKPKRKREKK
560 570 580 590 600
EKKKKRKAEK HRGRIGIDED DKGPRAPRPP QPKKSKKAGG GGSNATTLSH
610 620 630 640 650
PGFGTSGGSS NKLPKKSQKT APPVLPTGYD SEEEEESRPM SYDEKRQLSL
660 670 680 690 700
DINKLPGEKL GRVVHIIQAR EPSLRDSNPE EIEIDFETLK PSTLRELERY
710 720 730 740 750
VLSCLRKKPR KPYTIRKPVG KTKEELALEK KRELEKRLQD VSGQLNSTKK
760 770 780 790
PPKKASEKTE SSAQQVAVSR LSASSSSSDS SSSSSSSSSS DTSDSDSG
Length:798
Mass (Da):88,067
Last modified:July 5, 2004 - v1
Checksum:i08DD57FBF1385E96
GO
Isoform 2 (identifier: Q7JJ13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:752
Mass (Da):83,271
Checksum:iDA931FC6F03FA1FD
GO

Sequence cautioni

The sequence BAD90273 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169E → K in BAE28228 (PubMed:16141072).Curated1
Sequence conflicti199A → G in AAC24810 (PubMed:9811568).Curated1
Sequence conflicti691P → L in BAD90273 (Ref. 6) Curated1
Sequence conflicti765 – 767QVA → LVP in AAC24810 (PubMed:9811568).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226011 – 46Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045462 mRNA Translation: AAC24810.1
AB010246 mRNA Translation: BAA24377.1
AB010247 mRNA Translation: BAA24378.1
AB010248 mRNA Translation: BAA24379.1
AB212273 mRNA Translation: BAD97682.1
D89801 Genomic DNA Translation: BAA25416.1
AL009226 Genomic DNA Translation: CAA15818.1
AL009226 Genomic DNA Translation: CAA15819.1
AF100956 Genomic DNA Translation: AAC69907.1
AK147918 mRNA Translation: BAE28228.1
AK158970 mRNA Translation: BAE34749.1
AK168525 mRNA Translation: BAE40404.1
AK220444 mRNA Translation: BAD90273.1 Different initiation.
AF318183 mRNA Translation: AAK07919.1
CCDSiCCDS28641.1 [Q7JJ13-1]
RefSeqiNP_001191902.1, NM_001204973.1 [Q7JJ13-1]
NP_034368.2, NM_010238.3 [Q7JJ13-1]
UniGeneiMm.3444

Genome annotation databases

EnsembliENSMUST00000025193; ENSMUSP00000025193; ENSMUSG00000024335 [Q7JJ13-1]
ENSMUST00000114242; ENSMUSP00000109880; ENSMUSG00000024335 [Q7JJ13-1]
GeneIDi14312
KEGGimmu:14312
UCSCiuc008cbi.1 mouse [Q7JJ13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBRD2_MOUSE
AccessioniPrimary (citable) accession number: Q7JJ13
Secondary accession number(s): O54795
, O88411, Q3UGI0, Q5DTS6, Q794H7, Q794H9, Q99PC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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