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Q7G4P2

- LCB1C_ORYSJ

UniProt

Q7G4P2 - LCB1C_ORYSJ

Protein

Long chain base biosynthesis protein 1c

Gene

Os10g0189600

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 constitutes the catalytic core By similarity.By similarity

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. sphingolipid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_220105. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long chain base biosynthesis protein 1c (EC:2.3.1.50)
    Gene namesi
    Ordered Locus Names:Os10g0189600, LOC_Os10g11200
    ORF Names:OsJ_30932, OSJNBa0079H13
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 10

    Organism-specific databases

    GrameneiQ7G4P2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482Long chain base biosynthesis protein 1cPRO_0000419149Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer with LCB2. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1 and LCB2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7G4P2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000216602.
    KOiK00654.
    OMAiMVDESHA.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7G4P2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEMVLPVAN ATAAALARVS AVFNAPLARA VVFGIHIDGH LVVEGLLIAA    50
    ILFQLSRKSY KPPKKPLTER EVDELCDDWQ PEPLCPPIKE GARIDTPTLE 100
    SAAGPHTTVD GKEVVNFASA NYLGLIGNEK IIDSCVGSVE KYGVGSCGPR 150
    SFYGTIDVHL DCESKIANFL GTQDSILYSY GISTIFSVIP AFCKKGDIIV 200
    ADEGVHWAVQ NGLQLSRSTV VYFKHNDMAS LASILEKLTH GNKHTEKIRR 250
    YIVVEAIYQN SGQIAPLDEI VRLKEKYRFR VILEESHSFG VLGKSGRGLA 300
    EHYGVPVEKI DIITAGMGNA LATDGGFCTG SVRVVDHQRL SSSGYVFSAS 350
    LPPYLASAAM SAVNHLEENP SVLANLRSNI ALLHKELSDI PGLEIASNIL 400
    SPIVFLKLKT PTGSAVADLE LLEIIAEKVL MEDSVFIAAT KRSSLDKCRL 450
    PVGIRLFVSA GHTESDIFKV SASLKRVAAS VV 482
    Length:482
    Mass (Da):51,995
    Last modified:August 22, 2006 - v2
    Checksum:iBC5AB3DFACF2D8F3
    GO

    Sequence cautioni

    The sequence AAX95555.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EEE50683.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti157 – 1571D → N in AK100991. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104616 Genomic DNA. Translation: AAX95555.1. Sequence problems.
    DP000086 Genomic DNA. Translation: AAP52538.2.
    AP008216 Genomic DNA. Translation: BAF26186.1.
    CM000147 Genomic DNA. Translation: EEE50683.1. Sequence problems.
    AK100991 mRNA. No translation available.
    RefSeqiNP_001064272.1. NM_001070807.1.
    UniGeneiOs.32642.

    Genome annotation databases

    EnsemblPlantsiOS10T0189600-01; OS10T0189600-01; OS10G0189600.
    OS10T0189600-02; OS10T0189600-02; OS10G0189600.
    GeneIDi4348231.
    KEGGiosa:4348231.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104616 Genomic DNA. Translation: AAX95555.1 . Sequence problems.
    DP000086 Genomic DNA. Translation: AAP52538.2 .
    AP008216 Genomic DNA. Translation: BAF26186.1 .
    CM000147 Genomic DNA. Translation: EEE50683.1 . Sequence problems.
    AK100991 mRNA. No translation available.
    RefSeqi NP_001064272.1. NM_001070807.1.
    UniGenei Os.32642.

    3D structure databases

    ProteinModelPortali Q7G4P2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS10T0189600-01 ; OS10T0189600-01 ; OS10G0189600 .
    OS10T0189600-02 ; OS10T0189600-02 ; OS10G0189600 .
    GeneIDi 4348231.
    KEGGi osa:4348231.

    Organism-specific databases

    Gramenei Q7G4P2.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000216602.
    KOi K00654.
    OMAi MVDESHA.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_220105. Sphingolipid de novo biosynthesis.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "In-depth view of structure, activity, and evolution of rice chromosome 10."
      Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S., Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D., Oates R., Palmer M., Pries G., Gibson J., Anderson H.
      , Paradkar M., Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F., Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M., Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R., Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F., Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D., Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R., Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K., Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S., Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S., Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R., Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M., Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R., Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E., Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.
      Science 300:1566-1569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLCB1C_ORYSJ
    AccessioniPrimary (citable) accession number: Q7G4P2
    Secondary accession number(s): B9G7U8, Q53QX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3