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Protein

Putative ABC transporter C family member 15

Gene

ABCC15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Pump for glutathione S-conjugates.By similarity

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi249 – 256ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi836 – 843ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G60970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ABC transporter C family member 15 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.15
Short name:
AtABCC15
Alternative name(s):
ATP-energized glutathione S-conjugate pump 15
Glutathione S-conjugate-transporting ATPase 15
Putative multidrug resistance-associated protein 15
Gene namesi
Name:ABCC15
Synonyms:MRP15
Ordered Locus Names:At3g60970
ORF Names:T27I15.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G60970.
TAIRilocus:2100987. AT3G60970.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei36 – 56HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei125 – 145HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei151 – 171HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei481 – 503HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei523 – 543HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei595 – 615HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei714 – 734HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei738 – 758HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260861 – 1053Putative ABC transporter C family member 15Add BLAST1053

Proteomic databases

PaxDbiQ7FB56.

Expressioni

Gene expression databases

GenevisibleiQ7FB56. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G60970.1.

Structurei

3D structure databases

ProteinModelPortaliQ7FB56.
SMRiQ7FB56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 180ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST180
Domaini214 – 437ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini483 – 765ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST283
Domaini804 – 1036ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ7FB56.
OMAiAFQVEQM.
OrthoDBiEOG093600HI.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7FB56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVDVQRITD FIWYVNSIWM LPIQIFSAIY ILQKHLGLGA LAALVTTLMV
60 70 80 90 100
MACNYPLTRL QRNYQSDIMN AKDDRMKATS EILKNMKILK LQAWDNQFLN
110 120 130 140 150
KVKTLRKKEY DCLWKSLRLQ DFTTFILWGA PSLISVVTFV TCMLMGVKLT
160 170 180 190 200
AGAVLSALAT FQMLQSPIFG LPDLLSALVQ SKVSADRIAS YLQQSETQKD
210 220 230 240 250
AVEYCSNDHT EFSVEIENGA FSWEPESSRP TLDDIELKVK SGMKVAICGA
260 270 280 290 300
VGSGKSSLPS SILGEIQKLK GTVRVSGKQA YVPQSPWILS GTIRDNILFG
310 320 330 340 350
SIYESEKYER TVKACALIKD FELFSNGDLT EIGERGINMS GGQKQRIQIA
360 370 380 390 400
RAVYQNADIY LLDDPFSAVD AHTGRELFED CLMGILKDKT VLYVTHQVEF
410 420 430 440 450
LPAADLILVM QNGRVMQAGK FEELLKQNIG FEVLTQCDSE HNISTENKKK
460 470 480 490 500
EAKLVQDEET EKGVIGKEVY LTYLTTVKGG LLVPFIILAQ SCFQMLQIAS
510 520 530 540 550
NYWMAWTAPP TAESIPKLGM GRILLVYALL AAGSSLCVLA RTILVAIGGL
560 570 580 590 600
STAETFFSRM LCSIFRAPMS YFDSTPTGRI LNRASTDQSV LDLEMAVKLG
610 620 630 640 650
WCAFSIIQIV GTIFVMSQVA WQVCVIFIPV AVACVFYQRY YTPTERELSR
660 670 680 690 700
MSGVERAPIL HHFAESLAGA TTIRAFDQRD RFISSNLVLI DSHSRPWFHV
710 720 730 740 750
ASAMEWLSFR LNLLSHFVFA FSLVLLVTLP EGVINPSIAG LGVTYGLSLN
760 770 780 790 800
VLQATVIWNI CNAENKMISV ERILQHSKIP SEAPLVIDDQ RPLDNWPNVG
810 820 830 840 850
SIVFRDLQVR YAEHFPAVLK NITCAFPGGK KIGVVGRTGS GKSTLIQALF
860 870 880 890 900
RIVEPSHGTI VIDNVDITKI GLHDLRSRLG IIPQDNALFD GTIRLNLDPL
910 920 930 940 950
AQYTDREIWE ALDKCQLGDV IRAKDEKLDA TVVENGENWS VGQRQLVCLG
960 970 980 990 1000
RVLLKKSNIL VLDEATASVD SATDGVIQKI INQEFKDRTV VTIAHRIHTV
1010 1020 1030 1040 1050
IESDLVLVLS DGRIAEFDSP AKLLQREDSF FSKLIKEYSL RSNHFAGSND

LLS
Length:1,053
Mass (Da):117,251
Last modified:December 14, 2011 - v2
Checksum:i4E88EB0FA9F51CA9
GO

Sequence cautioni

The sequence CAB94133 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL358732 Genomic DNA. Translation: CAB94133.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE80133.1.
PIRiT50518.
RefSeqiNP_191656.2. NM_115961.3.

Genome annotation databases

EnsemblPlantsiAT3G60970.1; AT3G60970.1; AT3G60970.
GeneIDi825269.
GrameneiAT3G60970.1; AT3G60970.1; AT3G60970.
KEGGiath:AT3G60970.

Similar proteinsi

Entry informationi

Entry nameiAB15C_ARATH
AccessioniPrimary (citable) accession number: Q7FB56
Secondary accession number(s): F4JD20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 14, 2011
Last modified: June 7, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Lacks some conserved transmembrane domains, which are one of the features of the ABC conjugate transporter subfamily.Curated
Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families