Reviewed, UniProtKB/Swiss-Prot Q7FB56 (AB15C_ARATH)

Names and origin

Protein names

Recommended name:
    Putative ABC transporter C family member 15
      Short name=ABC transporter ABCC.15
      Short name=AtABCC15
    EC=3.6.3.44
Alternative name(s):
    Putative multidrug resistance-associated protein 15
    Glutathione S-conjugate-transporting ATPase 15
    ATP-energized glutathione S-conjugate pump 15

Gene names

Name:	ABCC15
Synonyms:	MRP15
Ordered Locus Names:	At3g60970
ORF Names:	T27I15.60

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	1037 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Uncertain.

General annotation (Comments)

Function	Pump for glutathione S-conjugates By similarity.
Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Caution	Lacks some conserved transmembrane domains, which are one of the features of the ABC conjugate transporter subfamily. Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1037	1037	Putative ABC transporter C family member 15		PRO_0000226086
Regions
	Transmembrane	11 – 31	21	Potential
	Transmembrane	36 – 56	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	151 – 171	21	Potential
	Transmembrane	481 – 503	23	Potential
	Transmembrane	523 – 543	21	Potential
	Transmembrane	595 – 615	21	Potential
	Transmembrane	698 – 718	21	Potential
	Transmembrane	722 – 742	21	Potential
	Domain	1 – 180	180	ABC transmembrane type-1 1
	Domain	214 – 437	224	ABC transporter 1
	Domain	483 – 749	267	ABC transmembrane type-1 2
	Domain	788 – 1020	233	ABC transporter 2
	Nucleotide binding	249 – 256	8	ATP 1 Potential
	Nucleotide binding	820 – 827	8	ATP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7FB56-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9F33269074AEA247	FASTA	1,037	115,498
	10 20 30 40 50 60 MSVDVQRITD FIWYVNSIWM LPIQIFSAIY ILQKHLGLGA LAALVTTLMV MACNYPLTRL 70 80 90 100 110 120 QRNYQSDIMN AKDDRMKATS EILKNMKILK LQAWDNQFLN KVKTLRKKEY DCLWKSLRLQ 130 140 150 160 170 180 DFTTFILWGA PSLISVVTFV TCMLMGVKLT AGAVLSALAT FQMLQSPIFG LPDLLSALVQ 190 200 210 220 230 240 SKVSADRIAS YLQQSETQKD AVEYCSNDHT EFSVEIENGA FSWEPESSRP TLDDIELKVK 250 260 270 280 290 300 SGMKVAICGA VGSGKSSLPS SILGEIQKLK GTVRVSGKQA YVPQSPWILS GTIRDNILFG 310 320 330 340 350 360 SIYESEKYER TVKACALIKD FELFSNGDLT EIGERGINMS GGQKQRIQIA RAVYQNADIY 370 380 390 400 410 420 LLDDPFSAVD AHTGRELFED CLMGILKDKT VLYVTHQVEF LPAADLILVM QNGRVMQAGK 430 440 450 460 470 480 FEELLKQNIG FEVLTQCDSE HNISTENKKK EAKLVQDEET EKGVIGKEVY LTYLTTVKGG 490 500 510 520 530 540 LLVPFIILAQ SCFQMLQIAS NYWMAWTAPP TAESIPKLGM GRILLVYALL AAGSSLCVLA 550 560 570 580 590 600 RTILVAIGGL STAETFFSRM LCSIFRAPMS YFDSTPTGRI LNRASTDQSV LDLEMAVKLG 610 620 630 640 650 660 WCAFSIIQIV GTIFVMSQVA WQRYYTPTER ELSRMSGVER APILHHFAES LAGATTIRAF 670 680 690 700 710 720 DQRDRFISSN LVLIDSHSRP WFHVASAMEW LSFRLNLLSH FVFAFSLVLL VTLPEGVINP 730 740 750 760 770 780 SIAGLGVTYG LSLNVLQATV IWNICNAENK MISVERILQH SKIPSEAPLV IDDQRPLDNW 790 800 810 820 830 840 PNVGSIVFRD LQVRYAEHFP AVLKNITCAF PGGKKIGVVG RTGSGKSTLI QALFRIVEPS 850 860 870 880 890 900 HGTIVIDNVD ITKIGLHDLR SRLGIIPQDN ALFDGTIRLN LDPLAQYTDR EIWEALDKCQ 910 920 930 940 950 960 LGDVIRAKDE KLDATVVENG ENWSVGQRQL VCLGRVLLKK SNILVLDEAT ASVDSATDGV 970 980 990 1000 1010 1020 IQKIINQEFK DRTVVTIAHR IHTVIESDLV LVLSDGRIAE FDSPAKLLQR EDSFFSKLIK 1030 EYSLRSNHFA GSNDLLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"The Arabidopsis thaliana ABC protein superfamily, a complete inventory." Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A. J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[3]	"Multifunctionality of plant ABC transporters -- more than just detoxifiers." Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B. Planta 214:345-355(2002) [PubMed: 11855639] [Abstract] Cited for: GENE FAMILY.
[4]	"Plant ABC proteins - a unified nomenclature and updated inventory." Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L. Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL358732 Genomic DNA. Translation: CAB94133.1.
IPI	IPI00548328.
PIR	T50518.
RefSeq	NP_191656.1.
UniGene	At.70338
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	825269.
GenomeReviews	Gene locus AT3G60970 in contig BA000014_GR.
KEGG	ath:AT3G60970.
NMPDR	fig|3702.1.peg.17467.
Organism-specific databases
TAIR	At3g60970.
Phylogenomic databases
OMA	GRICIDE.
Enzyme and pathway databases
BRENDA	3.6.3.44. 302.
Gene expression databases
Genevestigator	Q7FB56.
GermOnline	AT3G60970. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AB15C_ARATH

Accession

Primary (citable) accession number: Q7FB56

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)