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Q7FAS1

- GLO3_ORYSJ

UniProt

Q7FAS1 - GLO3_ORYSJ

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Protein
Peroxisomal (S)-2-hydroxy-acid oxidase GLO3
Gene
GLO3, Os04g0623500, LOC_Os04g53210, OsJ_16217, OSJNBa0053K19.8
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Photorespiratory enzyme that can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase. Not required for oxalate accumulation By similarity.

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Substrate Reviewed prediction
Binding sitei107 – 1071FMN By similarity
Binding sitei128 – 1281FMN By similarity
Binding sitei130 – 1301Substrate By similarity
Binding sitei156 – 1561FMN By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei231 – 2311FMN By similarity
Active sitei255 – 2551Proton acceptor By similarity
Binding sitei258 – 2581Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi286 – 31025FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. glycolate oxidase activity Source: UniProtKB
  3. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  4. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  5. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. defense response signaling pathway, resistance gene-independent Source: EnsemblPlants/Gramene
  2. defense response to bacterium Source: EnsemblPlants/Gramene
  3. hydrogen peroxide biosynthetic process Source: EnsemblPlants/Gramene
  4. modulation by virus of host morphology or physiology Source: UniProtKB
  5. oxidative photosynthetic carbon pathway Source: UniProtKB-UniPathway
  6. photorespiration Source: UniProtKB
  7. regulation of photosynthesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolate pathway, Host-virus interaction, Photorespiration

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00951; UER00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO3 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 3
Short name:
GOX 3
Short name:
OsGLO3
Short chain alpha-hydroxy acid oxidase GLO3
Gene namesi
Name:GLO3
Ordered Locus Names:Os04g0623500, LOC_Os04g53210
ORF Names:OsJ_16217, OSJNBa0053K19.8
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 4

Organism-specific databases

GrameneiQ7FAS1.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Peroxisomal (S)-2-hydroxy-acid oxidase GLO3
PRO_0000403413Add
BLAST

Interactioni

Subunit structurei

Homotetramer or homooctamer. Interacts with rice dwarf virus (RDV) P8. This interaction promotes viral P8 relocation to virus factories peripheral to peroxisomes By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7FAS1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 360360FMN hydroxy acid dehydrogenase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi365 – 3673Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217463.
KOiK11517.
OMAiARIAVEY.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7FAS1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MELITNVSEY EQLAKQKLPK MIYDYYASGA EDQWTLKENR EAFSRILFRP    50
RILIDVSRIN MATNVLGFNI SMPIMIAPSA MQKMAHPEGE LATARAASAA 100
GTIMTLSSWS TSSVEEVNSA APGIRFFQLY VYKDRNIVRQ LVRRAELAGF 150
KAIALTVDTP RLGRREADIK NRFNLPPHLV LKNFEALDLG KMDKTNDSGL 200
ASYVASQVDR SLSWTDVKWL QTITSLPILV KGVMTAEDTR LAVESGAAGI 250
IVSNHGARQL DYVPATISCL EEVVREAKGR LPVFLDGGVR RGTDVFKALA 300
LGASGVFIGR PVLFSLAVDG EAGVRKVLQM LRDELELTMA LSGCTSLAEI 350
TRNHVITDSD RIRRSRL 367
Length:367
Mass (Da):40,533
Last modified:July 5, 2004 - v1
Checksum:iC1F607AE6F6AD6FB
GO
Isoform 2 (identifier: Q7FAS1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-307: Missing.

Show »
Length:365
Mass (Da):40,287
Checksum:i346F50317934DE96
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei306 – 3072Missing in isoform 2.
VSP_040390

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL606645 Genomic DNA. Translation: CAE03500.2.
AP008210 Genomic DNA. Translation: BAF15839.1.
CM000141 Genomic DNA. Translation: EEE61716.1.
AK060221 mRNA. Translation: BAG87371.1.
AK068638 mRNA. Translation: BAG91005.1.
RefSeqiNP_001053925.1. NM_001060460.1. [Q7FAS1-1]
UniGeneiOs.6585.

Genome annotation databases

EnsemblPlantsiOS04T0623500-02; OS04T0623500-02; OS04G0623500. [Q7FAS1-1]
GeneIDi4337048.
KEGGiosa:4337048.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL606645 Genomic DNA. Translation: CAE03500.2 .
AP008210 Genomic DNA. Translation: BAF15839.1 .
CM000141 Genomic DNA. Translation: EEE61716.1 .
AK060221 mRNA. Translation: BAG87371.1 .
AK068638 mRNA. Translation: BAG91005.1 .
RefSeqi NP_001053925.1. NM_001060460.1. [Q7FAS1-1 ]
UniGenei Os.6585.

3D structure databases

ProteinModelPortali Q7FAS1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS04T0623500-02 ; OS04T0623500-02 ; OS04G0623500 . [Q7FAS1-1 ]
GeneIDi 4337048.
KEGGi osa:4337048.

Organism-specific databases

Gramenei Q7FAS1.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217463.
KOi K11517.
OMAi ARIAVEY.

Enzyme and pathway databases

UniPathwayi UPA00951 ; UER00912 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: cv. Nipponbare.
  6. "Inducible antisense suppression of glycolate oxidase reveals its strong regulation over photosynthesis in rice."
    Xu H.-W., Zhang J., Zeng J., Jiang L., Liu E., Peng C., He Z.-H., Peng X.-X.
    J. Exp. Bot. 60:1799-1809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGLO3_ORYSJ
AccessioniPrimary (citable) accession number: Q7FAS1
Secondary accession number(s): B7E4S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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