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Protein

Calmodulin-5/6/7/8

Gene

PCM5

more
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

The expression of PCM7 was not investigated.
This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-5/6/7/8
Short name:
CaM-5/6/7/8
Gene namesi
Name:PCM5
AND
Name:PCM6
AND
Name:PCM7
AND
Name:PCM8
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001983052 – 149Calmodulin-5/6/7/8Add BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PRIDEiQ7DMN9

Expressioni

Tissue specificityi

High expression of PCM5 and 8 in stolon tips and stems, moderate in roots, and low in leaves. Steady-state expression of PCM6 in all the tissues tested, except in the leaves where the expression is lower.1 Publication

Developmental stagei

Expression of PCM5 and 8 reduced during tuber development.1 Publication

Inductioni

PCM5, PCM6 and PCM8 are not induced by touching.1 Publication

Gene expression databases

ExpressionAtlasiQ7DMN9 baseline

Interactioni

Protein-protein interaction databases

DIPiDIP-59736N
IntActiQ7DMN9, 1 interactor
STRINGi4113.PGSC0003DMT400058435

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 56Combined sources11
Beta strandi61 – 64Combined sources4
Helixi66 – 93Combined sources28
Beta strandi98 – 101Combined sources4
Helixi103 – 111Combined sources9
Turni112 – 114Combined sources3
Helixi119 – 129Combined sources11
Beta strandi134 – 138Combined sources5
Helixi139 – 146Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RFJX-ray2.00A1-149[»]
ProteinModelPortaliQ7DMN9
SMRiQ7DMN9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7DMN9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
InParanoidiQ7DMN9
KOiK02183
OMAiFVRMMTE
OrthoDBiEOG09360QIJ

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7DMN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD VDGDGQINYD EFVKVMMAK
Length:149
Mass (Da):16,848
Last modified:January 23, 2007 - v3
Checksum:iABF12D8A91762013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20294 Genomic DNA Translation: AAA85155.1
U20295 mRNA Translation: AAA62351.1
U20296 Genomic DNA Translation: AAA85156.1
U20297 Genomic DNA Translation: AAA85157.1
RefSeqiNP_001275359.1, NM_001288430.1
UniGeneiStu.20337

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693
GeneIDi102577873
GrameneiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693
KEGGisot:102577873

Similar proteinsi

Entry informationi

Entry nameiCALM5_SOLTU
AccessioniPrimary (citable) accession number: Q7DMN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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