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Protein

Calmodulin-5/6/7/8

Gene

PCM5

more
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121Add
BLAST
Calcium bindingi57 – 68122Add
BLAST
Calcium bindingi94 – 105123Add
BLAST
Calcium bindingi130 – 141124Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-5/6/7/8
Short name:
CaM-5/6/7/8
Gene namesi
Name:PCM5
AND
Name:PCM6
AND
Name:PCM7
AND
Name:PCM8
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 149148Calmodulin-5/6/7/8PRO_0000198305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei116 – 1161N6,N6,N6-trimethyllysineBy similarity

Keywords - PTMi

Acetylation, Methylation

Expressioni

Tissue specificityi

High expression of PCM5 and 8 in stolon tips and stems, moderate in roots, and low in leaves. Steady-state expression of PCM6 in all the tissues tested, except in the leaves where the expression is lower.1 Publication

Developmental stagei

Expression of PCM5 and 8 reduced during tuber development.1 Publication

Inductioni

PCM5, PCM6 and PCM8 are not induced by touching.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-59736N.
STRINGi4113.PGSC0003DMT400058435.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 2014Combined sources
Beta strandi25 – 284Combined sources
Helixi30 – 3910Combined sources
Helixi46 – 5611Combined sources
Beta strandi61 – 644Combined sources
Helixi66 – 9328Combined sources
Beta strandi98 – 1014Combined sources
Helixi103 – 1119Combined sources
Turni112 – 1143Combined sources
Helixi119 – 12911Combined sources
Beta strandi134 – 1385Combined sources
Helixi139 – 1468Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RFJX-ray2.00A1-149[»]
ProteinModelPortaliQ7DMN9.
SMRiQ7DMN9. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7DMN9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 14933EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
InParanoidiQ7DMN9.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG09360QIJ.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7DMN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD VDGDGQINYD EFVKVMMAK
Length:149
Mass (Da):16,848
Last modified:January 23, 2007 - v3
Checksum:iABF12D8A91762013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20294 Genomic DNA. Translation: AAA85155.1.
U20295 mRNA. Translation: AAA62351.1.
U20296 Genomic DNA. Translation: AAA85156.1.
U20297 Genomic DNA. Translation: AAA85157.1.
RefSeqiNP_001275359.1. NM_001288430.1.
UniGeneiStu.20337.

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
GeneIDi102577873.
GrameneiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
KEGGisot:102577873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20294 Genomic DNA. Translation: AAA85155.1.
U20295 mRNA. Translation: AAA62351.1.
U20296 Genomic DNA. Translation: AAA85156.1.
U20297 Genomic DNA. Translation: AAA85157.1.
RefSeqiNP_001275359.1. NM_001288430.1.
UniGeneiStu.20337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RFJX-ray2.00A1-149[»]
ProteinModelPortaliQ7DMN9.
SMRiQ7DMN9. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59736N.
STRINGi4113.PGSC0003DMT400058435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
GeneIDi102577873.
GrameneiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
KEGGisot:102577873.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
InParanoidiQ7DMN9.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG09360QIJ.

Miscellaneous databases

EvolutionaryTraceiQ7DMN9.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM5_SOLTU
AccessioniPrimary (citable) accession number: Q7DMN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The expression of PCM7 was not investigated.
This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.