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Protein

Calmodulin-5/6/7/8

Gene

PCM5

more
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-5/6/7/8
Short name:
CaM-5/6/7/8
Gene namesi
Name:PCM5
AND
Name:PCM6
AND
Name:PCM7
AND
Name:PCM8
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001983052 – 149Calmodulin-5/6/7/8Add BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Expressioni

Tissue specificityi

High expression of PCM5 and 8 in stolon tips and stems, moderate in roots, and low in leaves. Steady-state expression of PCM6 in all the tissues tested, except in the leaves where the expression is lower.1 Publication

Developmental stagei

Expression of PCM5 and 8 reduced during tuber development.1 Publication

Inductioni

PCM5, PCM6 and PCM8 are not induced by touching.1 Publication

Interactioni

Protein-protein interaction databases

DIPiDIP-59736N.
STRINGi4113.PGSC0003DMT400058435.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 56Combined sources11
Beta strandi61 – 64Combined sources4
Helixi66 – 93Combined sources28
Beta strandi98 – 101Combined sources4
Helixi103 – 111Combined sources9
Turni112 – 114Combined sources3
Helixi119 – 129Combined sources11
Beta strandi134 – 138Combined sources5
Helixi139 – 146Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RFJX-ray2.00A1-149[»]
ProteinModelPortaliQ7DMN9.
SMRiQ7DMN9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7DMN9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
InParanoidiQ7DMN9.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG09360QIJ.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7DMN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD VDGDGQINYD EFVKVMMAK
Length:149
Mass (Da):16,848
Last modified:January 23, 2007 - v3
Checksum:iABF12D8A91762013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20294 Genomic DNA. Translation: AAA85155.1.
U20295 mRNA. Translation: AAA62351.1.
U20296 Genomic DNA. Translation: AAA85156.1.
U20297 Genomic DNA. Translation: AAA85157.1.
RefSeqiNP_001275359.1. NM_001288430.1.
UniGeneiStu.20337.

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
GeneIDi102577873.
GrameneiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
KEGGisot:102577873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20294 Genomic DNA. Translation: AAA85155.1.
U20295 mRNA. Translation: AAA62351.1.
U20296 Genomic DNA. Translation: AAA85156.1.
U20297 Genomic DNA. Translation: AAA85157.1.
RefSeqiNP_001275359.1. NM_001288430.1.
UniGeneiStu.20337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RFJX-ray2.00A1-149[»]
ProteinModelPortaliQ7DMN9.
SMRiQ7DMN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59736N.
STRINGi4113.PGSC0003DMT400058435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
GeneIDi102577873.
GrameneiPGSC0003DMT400058435; PGSC0003DMT400058435; PGSC0003DMG400022693.
KEGGisot:102577873.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
InParanoidiQ7DMN9.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG09360QIJ.

Miscellaneous databases

EvolutionaryTraceiQ7DMN9.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM5_SOLTU
AccessioniPrimary (citable) accession number: Q7DMN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The expression of PCM7 was not investigated.
This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.