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Protein

Dihydropteroate synthase

Gene

sulII

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase, Dihydropteroate synthase (sulII), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (sul1), Dihydropteroate synthase (B7947_10805), Dihydropteroate synthase (folP), Dihydropteroate synthase (BFX32_03030), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processFolate biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthaseUniRule annotation (EC:2.5.1.15UniRule annotation)
Short name:
DHPSUniRule annotation
Alternative name(s):
Dihydropteroate pyrophosphorylaseUniRule annotation
Gene namesi
Name:sulIIImported
Synonyms:folPImported, sul2Imported
ORF Names:EN12_02905Imported, VC1786ICE_13Imported, Vcrx029Imported
Encoded oniPlasmid pVC1447Imported
Plasmid pVCR94deltaXImported
OrganismiVibrio choleraeImported
Taxonomic identifieri666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000036184 Componenti: Chromosome 1

Structurei

3D structure databases

SMRiQ7DFV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 259Pterin-bindingInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the DHPS family.UniRule annotation

Phylogenomic databases

KOiK18824.

Family and domain databases

CDDicd00739. DHPS. 1 hit.
InterProiView protein in InterPro
IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
PfamiView protein in Pfam
PF00809. Pterin_bind. 1 hit.
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiView protein in PROSITE
PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7DFV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSLIIFGI VNITSDSFSD GGRYLAPDAA IAQARKLMAE GADVIDLGPA
60 70 80 90 100
SSNPDAAPVS SDTEIARIAP VLDALKADGI PVSLDSYQPA TQAYALSRGV
110 120 130 140 150
AYLNDIRGFP DAAFYPQLAK SSAKLVVMHS VQDGQADRRE APAGDIMDHI
160 170 180 190 200
AAFFDARIAA LTGAGIKRNR LVLDPGMGFF LGAAPETSLS VLARFDELRL
210 220 230 240 250
RFDLPVLLSV SRKSFLRALT GRGPGDVGAA TLAAELAAAA GGADFIRTHE
260 270
PRPLRDGLAV LAALKETARI R
Length:271
Mass (Da):28,470
Last modified:July 5, 2004 - v1
Checksum:i4B00E71A3F7970FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034138 Genomic DNA. Translation: AAK64592.1.
AY055428 Genomic DNA. Translation: AAL59753.1.
JN648379 Genomic DNA. Translation: AEU11386.1.
KF551948 Genomic DNA. Translation: AHC56386.1.
KC886257 Genomic DNA. Translation: AHM25058.1.
KM083064 Genomic DNA. Translation: AIW55726.1.
CP007653 Genomic DNA. Translation: AKO74201.1.
KT151654 Genomic DNA. Translation: ALP44376.1.
KT151655 Genomic DNA. Translation: ALP44463.1.
KT151656 Genomic DNA. Translation: ALP44557.1.
KT151657 Genomic DNA. Translation: ALP44643.1.
KT151658 Genomic DNA. Translation: ALP44735.1.
KT151659 Genomic DNA. Translation: ALP44828.1.
KT151660 Genomic DNA. Translation: ALP44928.1.
KT151661 Genomic DNA. Translation: ALP45012.1.
KT151662 Genomic DNA. Translation: ALP45099.1.
KT151663 Genomic DNA. Translation: ALP45209.1.
KT151664 Genomic DNA. Translation: ALP45309.1.
AB114188 Genomic DNA. Translation: BAC79069.1.
CGII01000180 Genomic DNA. Translation: CPR29426.1.
CGIJ01000180 Genomic DNA. Translation: CPR29428.1.
RefSeqiWP_001043260.1. NZ_MWFO01000124.1.
YP_008997665.1. NC_023291.1.

Genome annotation databases

EnsemblBacteriaiAKO74201; AKO74201; EN12_02905.
GeneIDi18156529.
32365434.
KEGGivcq:EN18_05275.
vcq:EN18_06335.
vcq:EN18_06385.
PATRICifig|666.1969.peg.3723.

Similar proteinsi

Entry informationi

Entry nameiQ7DFV9_VIBCL
AccessioniPrimary (citable) accession number: Q7DFV9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported