ID   Q7DAD9_MYCTO            Unreviewed;       491 AA.
AC   Q7DAD9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 112.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   OrderedLocusNames=MT0155 {ECO:0000313|EMBL:AAK44379.1};
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331 {ECO:0000313|EMBL:AAK44379.1, ECO:0000313|Proteomes:UP000001020};
RN   [1] {ECO:0000313|EMBL:AAK44379.1, ECO:0000313|Proteomes:UP000001020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh {ECO:0000313|Proteomes:UP000001020};
RX   PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L.,
RA   Delcher A., Utterback T., Weidman J., Khouri H., Gill J., Mikula A.,
RA   Bishai W., Jacobs Jr W.R.Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC       ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AE000516; AAK44379.1; -; Genomic_DNA.
DR   RefSeq; WP_003913557.1; NZ_KK341227.1.
DR   AlphaFoldDB; Q7DAD9; -.
DR   KEGG; mtc:MT0155; -.
DR   HOGENOM; CLU_005391_3_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   CDD; cd07087; ALDH_F3-13-14_CALDH-like; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR036492};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001020}.
FT   DOMAIN          23..462
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        239
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        273
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ   SEQUENCE   491 AA;  53453 MW;  EAD772943D6A2987 CRC64;
     MMTTESVARK TQKSETEAPR EPAPVSDEKQ TDVAKTVARL RKTFASGRTR SVEWRKQQLR
     ALQKLMDENE DAIAAALAED LDRNPFEAYL ADIATTSAEA KYAAKRVRRW MRRRYLLLEV
     PQLPGRGWVE YEPYGTVLII GAWNYPFYLT LGPAVGAIAA GNAVVLKPSE IAAASAHLMT
     ELVYRYLDTE AIAVVQGDGA VSQELIAQGF DRVMFTGGTE IGRKVYEGAA PHLTPVTLEL
     GGKSPVIVAA DADVDVAAKR IAWIKLLNAG QTCVAPDYVL ADATVRDELV SKITAALTKF
     RSGAPQGMRI VNQRQFDRLS GYLAAAKTDA AADGGGVVVG GDCDASNLRI QPTVVVDPDP
     DGPLMSNEIF GPILPVVTVK SLDDAIRFVN SRPKPLSAYL FTKSRAVRER VIREVPAGGM
     MVNHLAFQVS TAKLPFGGVG ASGMGAYHGR WGFEEFSHRK SVLTKPTRPD LSSFIYPPYT
     ERAIKVARRL F
//