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Protein

Acetyltransferase Atu2258

Gene

Atu2258

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers glucosamine 6-phosphate or dopamine. It can also use the thialysine, N(8)-acetylspermidine, chloramphenicol, puromycin, polymyxin B, and 4-aminobutyrate ethyl ester.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciAGRO:ATU2258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase Atu22581 Publication (EC:2.3.1.-)
Alternative name(s):
GCN5-related N-acetyltransferase1 Publication
Short name:
GNAT1 Publication
Gene namesi
Ordered Locus Names:Atu2258
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Acetyltransferase Atu2258PRO_0000433351Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu2258.

Structurei

Secondary structure

1
137
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2919Combined sources
Beta strandi35 – 428Combined sources
Beta strandi48 – 5710Combined sources
Beta strandi60 – 678Combined sources
Helixi70 – 723Combined sources
Beta strandi74 – 763Combined sources
Helixi77 – 9115Combined sources
Beta strandi96 – 1027Combined sources
Helixi104 – 11310Combined sources
Beta strandi116 – 1216Combined sources
Beta strandi130 – 1367Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G3AX-ray1.90A1-137[»]
ProteinModelPortaliQ7CXI0.
SMRiQ7CXI0. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7CXI0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 137137N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 683Coenzyme A bindingBy similarity
Regioni108 – 1103Coenzyme A bindingBy similarity

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105VEV. Bacteria.
ENOG41123JQ. LUCA.
HOGENOMiHOG000230129.
OrthoDBiEOG61040D.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7CXI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFVLSDVAD AEAEKAIRDP LVAYNLARFG ESDKRDLNIT IRNDDNSVTG
60 70 80 90 100
GLVGHTARGW LYVQLLFVPE AMRGQGIAPK LLAMAEEEAR KRGCMGAYID
110 120 130
TMNPDALRTY ERYGFTKIGS LGPLSSGQSI TWLEKRF
Length:137
Mass (Da):15,202
Last modified:January 15, 2008 - v2
Checksum:i7E906F947A5DA58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87999.2.
RefSeqiNP_355214.2. NC_003062.2.
WP_010972179.1. NC_003062.2.

Genome annotation databases

EnsemblBacteriaiAAK87999; AAK87999; Atu2258.
GeneIDi1134296.
KEGGiatu:Atu2258.
PATRICi20814297. VBIAgrTum91616_2268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA. Translation: AAK87999.2.
RefSeqiNP_355214.2. NC_003062.2.
WP_010972179.1. NC_003062.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G3AX-ray1.90A1-137[»]
ProteinModelPortaliQ7CXI0.
SMRiQ7CXI0. Positions 1-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu2258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK87999; AAK87999; Atu2258.
GeneIDi1134296.
KEGGiatu:Atu2258.
PATRICi20814297. VBIAgrTum91616_2268.

Phylogenomic databases

eggNOGiENOG4105VEV. Bacteria.
ENOG41123JQ. LUCA.
HOGENOMiHOG000230129.
OrthoDBiEOG61040D.

Enzyme and pathway databases

BioCyciAGRO:ATU2258-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ7CXI0.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  3. "Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-related N-acetyltransferases with unknown substrate specificity."
    Kuhn M.L., Majorek K.A., Minor W., Anderson W.F.
    Protein Sci. 22:222-230(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBSTRATE SPECIFICITY.
    Strain: C58 / ATCC 33970.
  4. "Crystal structure of putative acetyltransferase from Agrobacterium tumefaciens."
    Midwest center for structural genomics (MCSG)
    Submitted (FEB-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).

Entry informationi

Entry nameiATSE_AGRFC
AccessioniPrimary (citable) accession number: Q7CXI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: January 15, 2008
Last modified: November 11, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.