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Protein

Adenine deaminase 2

Gene

ade2

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciAGRO:ATU4426-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminase 2UniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
Adenase 2UniRule annotation
Short name:
Adenine aminase 2UniRule annotation
Gene namesi
Name:ade2UniRule annotation
Synonyms:adeC
Ordered Locus Names:Atu4426
ORF Names:AGR_L_883
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome linear

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Adenine deaminase 2PRO_0000142399Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu4426.

Structurei

Secondary structure

1
597
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 133Combined sources
Helixi16 – 2712Combined sources
Beta strandi32 – 387Combined sources
Beta strandi40 – 423Combined sources
Turni44 – 463Combined sources
Beta strandi49 – 513Combined sources
Beta strandi53 – 575Combined sources
Beta strandi60 – 656Combined sources
Beta strandi67 – 693Combined sources
Beta strandi73 – 786Combined sources
Beta strandi82 – 865Combined sources
Beta strandi88 – 936Combined sources
Helixi95 – 984Combined sources
Helixi102 – 1109Combined sources
Turni111 – 1133Combined sources
Beta strandi114 – 1196Combined sources
Helixi122 – 1287Combined sources
Helixi130 – 14011Combined sources
Beta strandi144 – 1518Combined sources
Beta strandi155 – 1584Combined sources
Turni159 – 1613Combined sources
Helixi170 – 1778Combined sources
Beta strandi182 – 1887Combined sources
Helixi191 – 1955Combined sources
Helixi199 – 21113Combined sources
Beta strandi214 – 2174Combined sources
Helixi224 – 2329Combined sources
Helixi244 – 2529Combined sources
Beta strandi256 – 2638Combined sources
Helixi264 – 2663Combined sources
Helixi267 – 27711Combined sources
Beta strandi284 – 2874Combined sources
Helixi293 – 2986Combined sources
Helixi302 – 31110Combined sources
Helixi316 – 3238Combined sources
Helixi325 – 3317Combined sources
Beta strandi336 – 3383Combined sources
Beta strandi347 – 3515Combined sources
Turni353 – 3553Combined sources
Beta strandi358 – 3636Combined sources
Beta strandi366 – 3705Combined sources
Beta strandi373 – 3764Combined sources
Helixi384 – 3863Combined sources
Helixi397 – 4004Combined sources
Beta strandi405 – 41915Combined sources
Beta strandi421 – 43010Combined sources
Beta strandi431 – 4344Combined sources
Beta strandi440 – 4467Combined sources
Beta strandi449 – 4524Combined sources
Beta strandi456 – 4649Combined sources
Beta strandi468 – 4747Combined sources
Turni477 – 4793Combined sources
Beta strandi482 – 4887Combined sources
Helixi489 – 50113Combined sources
Beta strandi504 – 5107Combined sources
Beta strandi513 – 5197Combined sources
Turni523 – 5253Combined sources
Beta strandi526 – 5294Combined sources
Helixi531 – 54818Combined sources
Turni553 – 5553Combined sources
Helixi558 – 5625Combined sources
Beta strandi569 – 5713Combined sources
Beta strandi576 – 5805Combined sources
Turni582 – 5843Combined sources
Beta strandi587 – 5893Combined sources
Beta strandi591 – 5944Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NQBX-ray2.21A/B1-597[»]
3T81X-ray2.63A/B1-597[»]
3T8LX-ray2.80A/B1-597[»]
ProteinModelPortaliQ7CUX4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7CUX4.

Family & Domainsi

Sequence similaritiesi

Belongs to the adenine deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPN. Bacteria.
COG1001. LUCA.
HOGENOMiHOG000276949.
KOiK01486.
OrthoDBiEOG622PNM.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01518. Adenine_deamin.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CUX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQIRLAEP ADLNDDTLRA RAVAAARGDQ RFDVLITGGT LVDVVTGELR
60 70 80 90 100
PADIGIVGAL IASVHEPASR RDAAQVIDAG GAYVSPGLID THMHIESSMI
110 120 130 140 150
TPAAYAAAVV ARGVTTIVWD PHEFGNVHGV DGVRWAAKAI ENLPLRAILL
160 170 180 190 200
APSCVPSAPG LERGGADFDA AILADLLSWP EIGGIAEIMN MRGVIERDPR
210 220 230 240 250
MSGIVQAGLA AEKLVCGHAR GLKNADLNAF MAAGVSSDHE LVSGEDLMAK
260 270 280 290 300
LRAGLTIELR GSHDHLLPEF VAALNTLGHL PQTVTLCTDD VFPDDLLQGG
310 320 330 340 350
GLDDVVRRLV RYGLKPEWAL RAATLNAAQR LGRSDLGLIA AGRRADIVVF
360 370 380 390 400
EDLNGFSARH VLASGRAVAE GGRMLVDIPT CDTTVLKGSM KLPLRMANDF
410 420 430 440 450
LVKSQGAKVR LATIDRPRFT QWGETEADVK DGFVVPPEGA TMISVTHRHG
460 470 480 490 500
MAEPTTKTGF LTGWGRWNGA FATTVSHDSH NLTVFGGNAG DMALAANAVI
510 520 530 540 550
GTGGGMAVAS EGKVTAILPL PLSGLVSDAP LEEVARAFED LREAVGKVVE
560 570 580 590
WQPPYLVFKA CFGATLACNI GPHQTDMGIA DVLTGKVMES PVIEVLG
Length:597
Mass (Da):62,811
Last modified:July 5, 2004 - v1
Checksum:i21D10CF0B7A7478B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007870 Genomic DNA. Translation: AAK89014.1.
PIRiAF3100.
D98186.
RefSeqiNP_356229.1. NC_003063.2.
WP_010973838.1. NC_003063.2.

Genome annotation databases

EnsemblBacteriaiAAK89014; AAK89014; Atu4426.
GeneIDi1136300.
KEGGiatu:Atu4426.
PATRICi20818277. VBIAgrTum91616_4234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007870 Genomic DNA. Translation: AAK89014.1.
PIRiAF3100.
D98186.
RefSeqiNP_356229.1. NC_003063.2.
WP_010973838.1. NC_003063.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NQBX-ray2.21A/B1-597[»]
3T81X-ray2.63A/B1-597[»]
3T8LX-ray2.80A/B1-597[»]
ProteinModelPortaliQ7CUX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu4426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK89014; AAK89014; Atu4426.
GeneIDi1136300.
KEGGiatu:Atu4426.
PATRICi20818277. VBIAgrTum91616_4234.

Phylogenomic databases

eggNOGiENOG4105CPN. Bacteria.
COG1001. LUCA.
HOGENOMiHOG000276949.
KOiK01486.
OrthoDBiEOG622PNM.

Enzyme and pathway databases

BioCyciAGRO:ATU4426-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ7CUX4.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01518. Adenine_deamin.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C58 / ATCC 33970.

Entry informationi

Entry nameiADEC2_AGRFC
AccessioniPrimary (citable) accession number: Q7CUX4
Secondary accession number(s): Q8U7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.