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Protein

Adenine deaminase 2

Gene

ade2

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciAGRO:ATU4426-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminase 2UniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
Adenase 2UniRule annotation
Short name:
Adenine aminase 2UniRule annotation
Gene namesi
Name:ade2UniRule annotation
Synonyms:adeC
Ordered Locus Names:Atu4426
ORF Names:AGR_L_883
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome linear

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001423991 – 597Adenine deaminase 2Add BLAST597

Interactioni

Protein-protein interaction databases

STRINGi176299.Atu4426.

Structurei

Secondary structure

1597
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 13Combined sources3
Helixi16 – 27Combined sources12
Beta strandi32 – 38Combined sources7
Beta strandi40 – 42Combined sources3
Turni44 – 46Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi53 – 57Combined sources5
Beta strandi60 – 65Combined sources6
Beta strandi67 – 69Combined sources3
Beta strandi73 – 78Combined sources6
Beta strandi82 – 86Combined sources5
Beta strandi88 – 93Combined sources6
Helixi95 – 98Combined sources4
Helixi102 – 110Combined sources9
Turni111 – 113Combined sources3
Beta strandi114 – 119Combined sources6
Helixi122 – 128Combined sources7
Helixi130 – 140Combined sources11
Beta strandi144 – 151Combined sources8
Beta strandi155 – 158Combined sources4
Turni159 – 161Combined sources3
Helixi170 – 177Combined sources8
Beta strandi182 – 188Combined sources7
Helixi191 – 195Combined sources5
Helixi199 – 211Combined sources13
Beta strandi214 – 217Combined sources4
Helixi224 – 232Combined sources9
Helixi244 – 252Combined sources9
Beta strandi256 – 263Combined sources8
Helixi264 – 266Combined sources3
Helixi267 – 277Combined sources11
Beta strandi284 – 287Combined sources4
Helixi293 – 298Combined sources6
Helixi302 – 311Combined sources10
Helixi316 – 323Combined sources8
Helixi325 – 331Combined sources7
Beta strandi336 – 338Combined sources3
Beta strandi347 – 351Combined sources5
Turni353 – 355Combined sources3
Beta strandi358 – 363Combined sources6
Beta strandi366 – 370Combined sources5
Beta strandi373 – 376Combined sources4
Helixi384 – 386Combined sources3
Helixi397 – 400Combined sources4
Beta strandi405 – 419Combined sources15
Beta strandi421 – 430Combined sources10
Beta strandi431 – 434Combined sources4
Beta strandi440 – 446Combined sources7
Beta strandi449 – 452Combined sources4
Beta strandi456 – 464Combined sources9
Beta strandi468 – 474Combined sources7
Turni477 – 479Combined sources3
Beta strandi482 – 488Combined sources7
Helixi489 – 501Combined sources13
Beta strandi504 – 510Combined sources7
Beta strandi513 – 519Combined sources7
Turni523 – 525Combined sources3
Beta strandi526 – 529Combined sources4
Helixi531 – 548Combined sources18
Turni553 – 555Combined sources3
Helixi558 – 562Combined sources5
Beta strandi569 – 571Combined sources3
Beta strandi576 – 580Combined sources5
Turni582 – 584Combined sources3
Beta strandi587 – 589Combined sources3
Beta strandi591 – 594Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NQBX-ray2.21A/B1-597[»]
3T81X-ray2.63A/B1-597[»]
3T8LX-ray2.80A/B1-597[»]
ProteinModelPortaliQ7CUX4.
SMRiQ7CUX4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7CUX4.

Family & Domainsi

Sequence similaritiesi

Belongs to the adenine deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPN. Bacteria.
COG1001. LUCA.
HOGENOMiHOG000276949.
KOiK01486.
OMAiAGVTSDH.

Family and domain databases

CDDicd01295. AdeC. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01518. Adenine_deamin. 1 hit.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CUX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQIRLAEP ADLNDDTLRA RAVAAARGDQ RFDVLITGGT LVDVVTGELR
60 70 80 90 100
PADIGIVGAL IASVHEPASR RDAAQVIDAG GAYVSPGLID THMHIESSMI
110 120 130 140 150
TPAAYAAAVV ARGVTTIVWD PHEFGNVHGV DGVRWAAKAI ENLPLRAILL
160 170 180 190 200
APSCVPSAPG LERGGADFDA AILADLLSWP EIGGIAEIMN MRGVIERDPR
210 220 230 240 250
MSGIVQAGLA AEKLVCGHAR GLKNADLNAF MAAGVSSDHE LVSGEDLMAK
260 270 280 290 300
LRAGLTIELR GSHDHLLPEF VAALNTLGHL PQTVTLCTDD VFPDDLLQGG
310 320 330 340 350
GLDDVVRRLV RYGLKPEWAL RAATLNAAQR LGRSDLGLIA AGRRADIVVF
360 370 380 390 400
EDLNGFSARH VLASGRAVAE GGRMLVDIPT CDTTVLKGSM KLPLRMANDF
410 420 430 440 450
LVKSQGAKVR LATIDRPRFT QWGETEADVK DGFVVPPEGA TMISVTHRHG
460 470 480 490 500
MAEPTTKTGF LTGWGRWNGA FATTVSHDSH NLTVFGGNAG DMALAANAVI
510 520 530 540 550
GTGGGMAVAS EGKVTAILPL PLSGLVSDAP LEEVARAFED LREAVGKVVE
560 570 580 590
WQPPYLVFKA CFGATLACNI GPHQTDMGIA DVLTGKVMES PVIEVLG
Length:597
Mass (Da):62,811
Last modified:July 5, 2004 - v1
Checksum:i21D10CF0B7A7478B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007870 Genomic DNA. Translation: AAK89014.1.
PIRiAF3100.
D98186.
RefSeqiNP_356229.1. NC_003063.2.
WP_010973838.1. NC_003063.2.

Genome annotation databases

EnsemblBacteriaiAAK89014; AAK89014; Atu4426.
GeneIDi1136300.
KEGGiatu:Atu4426.
PATRICi20818277. VBIAgrTum91616_4234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007870 Genomic DNA. Translation: AAK89014.1.
PIRiAF3100.
D98186.
RefSeqiNP_356229.1. NC_003063.2.
WP_010973838.1. NC_003063.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NQBX-ray2.21A/B1-597[»]
3T81X-ray2.63A/B1-597[»]
3T8LX-ray2.80A/B1-597[»]
ProteinModelPortaliQ7CUX4.
SMRiQ7CUX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu4426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK89014; AAK89014; Atu4426.
GeneIDi1136300.
KEGGiatu:Atu4426.
PATRICi20818277. VBIAgrTum91616_4234.

Phylogenomic databases

eggNOGiENOG4105CPN. Bacteria.
COG1001. LUCA.
HOGENOMiHOG000276949.
KOiK01486.
OMAiAGVTSDH.

Enzyme and pathway databases

BioCyciAGRO:ATU4426-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ7CUX4.

Family and domain databases

CDDicd01295. AdeC. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01518. Adenine_deamin. 1 hit.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADEC2_AGRFC
AccessioniPrimary (citable) accession number: Q7CUX4
Secondary accession number(s): Q8U7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.