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Protein
Submitted name:

Penicillin-binding protein 1b

Gene

pbp1b

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1975-MONOMER.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Submitted name:
Penicillin-binding protein 1bImported (EC:2.3.2.-Imported, EC:2.4.1.129Imported)
Gene namesi
Name:pbp1bImported
Ordered Locus Names:spr1909Imported
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

DrugBankiDB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB00567. Cephalexin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.
DB00319. Piperacillin.

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1909.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UWXX-ray2.39A101-791[»]
2XD1X-ray3.00A/B101-791[»]
2XD5X-ray2.50A/B323-791[»]
2Y2GX-ray2.05A/B101-791[»]
2Y2HX-ray1.96A/B101-791[»]
2Y2IX-ray1.78A101-791[»]
2Y2JX-ray2.06A101-791[»]
2Y2KX-ray2.09A101-791[»]
2Y2LX-ray2.07A/B101-791[»]
2Y2MX-ray1.62A101-791[»]
2Y2NX-ray2.07A101-791[»]
2Y2OX-ray1.88A101-791[»]
2Y2PX-ray1.62A101-791[»]
2Y2QX-ray2.15A/B101-791[»]
ProteinModelPortaliQ7CRA4.
SMRiQ7CRA4. Positions 337-789.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7CRA4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 302190TransglyInterPro annotationAdd
BLAST
Domaini425 – 658234TranspeptidaseInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000235110.
KOiK03693.
OMAiVVPFGRN.
OrthoDBiEOG6CGCKC.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7CRA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNQLNELKR KMLEFFQQKQ KNKKSARPGK KGSSTKKSKT LDKSAIFPAI
60 70 80 90 100
LLSIKALFNL LFVLGFLGGM LGAGIALGYG VALFDKVRVP QTEELVNQVK
110 120 130 140 150
DISSISEITY SDGTVIASIE SDLLRTSISS EQISENLKKA IIATEDEHFK
160 170 180 190 200
EHKGVVPKAV IRATLGKFVG LGSSSGGSTL TQQLIKQQVV GDAPTLARKA
210 220 230 240 250
AEIVDALALE RAMNKDEILT TYLNVAPFGR NNKGQNIAGA RQAAEGIFGV
260 270 280 290 300
DASQLTVPQA AFLAGLPQSP ITYSPYENTG ELKSDEDLEI GLRRAKAVLY
310 320 330 340 350
SMYRTGALSK DEYSQYKDYD LKQDFLPSGT VTGISRDYLY FTTLAEAQER
360 370 380 390 400
MYDYLAQRDN VSAKELKNEA TQKFYRDLAA KEIENGGYKI TTTIDQKIHS
410 420 430 440 450
AMQSAVADYG YLLDDGTGRV EVGNVLMDNQ TGAILGFVGG RNYQENQNNH
460 470 480 490 500
AFDTKRSPAS TTKPLLAYGI AIDQGLMGSE TILSNYPTNF ANGNPIMYAN
510 520 530 540 550
SKGTGMMTLG EALNYSWNIP AYWTYRMLRE NGVDVKGYME KMGYEIPEYG
560 570 580 590 600
IESLPMGGGI EVTVAQHTNG YQTLANNGVY HQKHVISKIE AADGRVVYEY
610 620 630 640 650
QDKPVQVYSK ATATIMQGLL REVLSSRVTT TFKSNLTSLN PTLANADWIG
660 670 680 690 700
KTGTTNQDEN MWLMLSTPRL TLGGWIGHDD NHSLSRRAGY SNNSNYMAHL
710 720 730 740 750
VNAIQQASPS IWGNERFALD PSVVKSEVLK STGQKPGKVS VEGKEVEVTG
760 770 780 790 800
STVTSYWANK SGAPATSYRF AIGGSDADYQ NAWSSIVGSL PTPSSSSSSS
810 820
SSSSDSSNSS TTRPSSSRAR R
Length:821
Mass (Da):89,481
Last modified:July 5, 2004 - v1
Checksum:iDA94560B4B8BD3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAL00711.1.
RefSeqiNP_359500.1. NC_003098.1.
WP_001180963.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAL00711; AAL00711; spr1909.
GeneIDi934893.
KEGGispr:spr1909.
PATRICi19703990. VBIStrPne107296_2058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAL00711.1.
RefSeqiNP_359500.1. NC_003098.1.
WP_001180963.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2UWXX-ray2.39A101-791[»]
2XD1X-ray3.00A/B101-791[»]
2XD5X-ray2.50A/B323-791[»]
2Y2GX-ray2.05A/B101-791[»]
2Y2HX-ray1.96A/B101-791[»]
2Y2IX-ray1.78A101-791[»]
2Y2JX-ray2.06A101-791[»]
2Y2KX-ray2.09A101-791[»]
2Y2LX-ray2.07A/B101-791[»]
2Y2MX-ray1.62A101-791[»]
2Y2NX-ray2.07A101-791[»]
2Y2OX-ray1.88A101-791[»]
2Y2PX-ray1.62A101-791[»]
2Y2QX-ray2.15A/B101-791[»]
ProteinModelPortaliQ7CRA4.
SMRiQ7CRA4. Positions 337-789.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr1909.

Chemistry

DrugBankiDB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB00567. Cephalexin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.
DB00319. Piperacillin.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL00711; AAL00711; spr1909.
GeneIDi934893.
KEGGispr:spr1909.
PATRICi19703990. VBIStrPne107296_2058.

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000235110.
KOiK03693.
OMAiVVPFGRN.
OrthoDBiEOG6CGCKC.

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1975-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ7CRA4.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6Imported.
  2. "Active site restructuring regulates ligand recognition in class A penicillin-binding proteins."
    Macheboeuf P., Di Guilmi A.M., Job V., Vernet T., Dideberg O., Dessen A.
    Proc. Natl. Acad. Sci. U.S.A. 102:577-582(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 101-791.
  3. "Structural Insights Into the Catalytic Mechanism and the Role of Streptococcus Pneumoniae Pbp1B."
    Macheboeuf P., Lemaire D., Jamin M., Dideberg O., Dessen A.
    Submitted (APR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 323-791.
  4. "Structure-guided design of cell wall biosynthesis inhibitors that overcome beta-lactam resistance in Staphylococcus aureus (MRSA)."
    Contreras-Martel C., Amoroso A., Woon E.C., Zervosen A., Inglis S., Martins A., Verlaine O., Rydzik A.M., Job V., Luxen A., Joris B., Schofield C.J., Dessen A.
    ACS Chem. Biol. 6:943-951(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 101-791.

Entry informationi

Entry nameiQ7CRA4_STRR6
AccessioniPrimary (citable) accession number: Q7CRA4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.