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Protein

D-erythrose-4-phosphate dehydrogenase

Gene

epd

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.UniRule annotation

Catalytic activityi

D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. D-erythrose-4-phosphate dehydrogenase (epd)
  2. Erythronate-4-phosphate dehydrogenase (pdxB)
  3. Phosphoserine aminotransferase (serC)
  4. 4-hydroxythreonine-4-phosphate dehydrogenase 1 (pdxA1), 4-hydroxythreonine-4-phosphate dehydrogenase 2 (pdxA2)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81NAD; via carbonyl oxygenUniRule annotation1
Active sitei155NucleophileUniRule annotation1
Sitei182Activates thiol group during catalysisUniRule annotation1
Binding sitei200SubstrateUniRule annotation1
Binding sitei236SubstrateUniRule annotation1
Binding sitei318NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 13NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00244; UER00309.

Names & Taxonomyi

Protein namesi
Recommended name:
D-erythrose-4-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.72UniRule annotation)
Short name:
E4PDHUniRule annotation
Gene namesi
Name:epdUniRule annotation
Ordered Locus Names:STM3070
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931591 – 348D-erythrose-4-phosphate dehydrogenaseAdd BLAST348

Proteomic databases

PaxDbiQ7CPU5.
PRIDEiQ7CPU5.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM3070.

Structurei

3D structure databases

ProteinModelPortaliQ7CPU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 156Substrate bindingUniRule annotation3
Regioni213 – 214Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C17. Bacteria.
COG0057. LUCA.
HOGENOMiHOG000071679.
KOiK03472.
OMAiHHDLRRT.
PhylomeDBiQ7CPU5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01640. E4P_dehydrog. 1 hit.
InterProiIPR006422. E4P_DH_bac.
IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10836. PTHR10836. 1 hit.
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01532. E4PD_g-proteo. 1 hit.
TIGR01534. GAPDH-I. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7CPU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRIAINGF GRIGRNVVRA LYESGRRAEI TVVAINELAD AAGMAHLLKY
60 70 80 90 100
DTSHGRFAWE VRHEREQLFV GDDVIRILHE RTLADLPWRE LGVDVVLDCT
110 120 130 140 150
GVYGNREHGE AHIAAGAKKV LFSHPGSNDL DATVVFGVNQ NQLRAEHRIV
160 170 180 190 200
SNASCTTNCI IPVIKLLDDA YGIESGTVTT IHSAMNDQQV IDAYHSDLRR
210 220 230 240 250
TRAASQSIIP VDTKLAAGIT RIFPQFNDRF EAIAVRVPTI NVTAIDLSVT
260 270 280 290 300
VKKPVKASEV NQLLQKAAQG AFHGIVDYTE SPLVSIDFNH DPHSAIVDGT
310 320 330 340
QTRVSGAHLI KTLVWCDNEW GFANRMLDTT LAMAAVGFRL DASASTKL
Length:348
Mass (Da):38,125
Last modified:July 5, 2004 - v1
Checksum:i5009E1EFBB31413A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21945.1.
RefSeqiNP_461986.1. NC_003197.1.
WP_000218338.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21945; AAL21945; STM3070.
GeneIDi1254593.
KEGGistm:STM3070.
PATRICi32384889. VBISalEnt20916_3253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21945.1.
RefSeqiNP_461986.1. NC_003197.1.
WP_000218338.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ7CPU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3070.

Proteomic databases

PaxDbiQ7CPU5.
PRIDEiQ7CPU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21945; AAL21945; STM3070.
GeneIDi1254593.
KEGGistm:STM3070.
PATRICi32384889. VBISalEnt20916_3253.

Phylogenomic databases

eggNOGiENOG4105C17. Bacteria.
COG0057. LUCA.
HOGENOMiHOG000071679.
KOiK03472.
OMAiHHDLRRT.
PhylomeDBiQ7CPU5.

Enzyme and pathway databases

UniPathwayiUPA00244; UER00309.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01640. E4P_dehydrog. 1 hit.
InterProiIPR006422. E4P_DH_bac.
IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10836. PTHR10836. 1 hit.
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01532. E4PD_g-proteo. 1 hit.
TIGR01534. GAPDH-I. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE4PD_SALTY
AccessioniPrimary (citable) accession number: Q7CPU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.