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Protein
Submitted name:

Sensory kinase in two-component regulatory system with CpxR

Gene

cpxA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinaseSAAS annotationImported, Transferase
Biological processTwo-component regulatory systemSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-4098-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
Sensory kinase in two-component regulatory system with CpxRImported (EC:2.7.3.-Imported)
Gene namesi
Name:cpxAImported
Ordered Locus Names:STM4058Imported
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 27HelicalSequence analysisAdd BLAST22
Transmembranei165 – 184HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ7CPC3
PRIDEiQ7CPC3

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4058

Structurei

3D structure databases

ProteinModelPortaliQ7CPC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 237HAMPInterPro annotationAdd BLAST54
Domaini245 – 455Histidine kinaseInterPro annotationAdd BLAST211

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili274 – 294Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG4105E0F Bacteria
ENOG410XTWD LUCA
HOGENOMiHOG000269851
KOiK07640
OMAiHHPRPWF
PhylomeDBiQ7CPC3

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.450.210, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR032404 CpxA_peri
IPR038515 CpxA_peri_sf
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF16527 CpxA_peri, 1 hit
PF00672 HAMP, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q7CPC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGSLTARIF AIFWLTLALV LMLVLMLPKL DSRQMTELLD SEQRQGLMIE
60 70 80 90 100
QHVEAELAND PPNDLMWWRR LFRAIDKWAP PGQRLLLVTS EGRVIGAERS
110 120 130 140 150
EMQIIRNFIG QADNADHPQK KKYGRVEMVG PFSVRDGEDN YQLYLIRPAS
160 170 180 190 200
SSQSDFINLL FDRPLLLLIV TMLVSSPLLL WLAWSLAKPA RKLKNAADEV
210 220 230 240 250
AQGNLRQHPE LEAGPQEFLA AGASFNQMVT ALERMMTSQQ RLLSDISHEL
260 270 280 290 300
RTPLTRLQLG TALLRRRGGE SKELERIETE AQRLDSMIND LLVMSRNQQK
310 320 330 340 350
NALVSETMKA NQLWGEVLDN AAFEAEQMGK SLTVNYPPGP WPLYGNPNAL
360 370 380 390 400
ESALENIVRN ALRYSHTKIE VGFSVDKDGI TITVDDDGPG VSPEDREQIF
410 420 430 440 450
RPFYRTDEAR DRESGGTGLG LAIVESAMQQ HRGWVKADDS PLGGLRLTLW

LPLYKRT
Length:457
Mass (Da):51,610
Last modified:July 5, 2004 - v1
Checksum:i5F7C8EEA944488FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL22898.1
RefSeqiNP_462939.1, NC_003197.2
WP_000580402.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL22898; AAL22898; STM4058
GeneIDi1255585
KEGGistm:STM4058
PATRICifig|99287.12.peg.4278

Similar proteinsi

Entry informationi

Entry nameiQ7CPC3_SALTY
AccessioniPrimary (citable) accession number: Q7CPC3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health