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Protein

Histidine kinase

Gene

cpxA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Two-component regulatory systemSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4088-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine kinaseSAAS annotation (EC:2.7.13.3SAAS annotation)
Gene namesi
Name:cpxAImported
Ordered Locus Names:STM4058Imported
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Imported
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotationSAAS annotation

Proteomic databases

PRIDEiQ7CPC3.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4058.

Structurei

3D structure databases

ProteinModelPortaliQ7CPC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains histidine kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000269851.
KOiK07640.
OMAiEHIFRPF.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ7CPC3.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_C.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7CPC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGSLTARIF AIFWLTLALV LMLVLMLPKL DSRQMTELLD SEQRQGLMIE
60 70 80 90 100
QHVEAELAND PPNDLMWWRR LFRAIDKWAP PGQRLLLVTS EGRVIGAERS
110 120 130 140 150
EMQIIRNFIG QADNADHPQK KKYGRVEMVG PFSVRDGEDN YQLYLIRPAS
160 170 180 190 200
SSQSDFINLL FDRPLLLLIV TMLVSSPLLL WLAWSLAKPA RKLKNAADEV
210 220 230 240 250
AQGNLRQHPE LEAGPQEFLA AGASFNQMVT ALERMMTSQQ RLLSDISHEL
260 270 280 290 300
RTPLTRLQLG TALLRRRGGE SKELERIETE AQRLDSMIND LLVMSRNQQK
310 320 330 340 350
NALVSETMKA NQLWGEVLDN AAFEAEQMGK SLTVNYPPGP WPLYGNPNAL
360 370 380 390 400
ESALENIVRN ALRYSHTKIE VGFSVDKDGI TITVDDDGPG VSPEDREQIF
410 420 430 440 450
RPFYRTDEAR DRESGGTGLG LAIVESAMQQ HRGWVKADDS PLGGLRLTLW

LPLYKRT
Length:457
Mass (Da):51,610
Last modified:July 5, 2004 - v1
Checksum:i5F7C8EEA944488FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22898.1.
RefSeqiNP_462939.1. NC_003197.1.
WP_000580402.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22898; AAL22898; STM4058.
GeneIDi1255585.
KEGGistm:STM4058.
PATRICi32386996. VBISalEnt20916_4278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL22898.1.
RefSeqiNP_462939.1. NC_003197.1.
WP_000580402.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ7CPC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4058.

Proteomic databases

PRIDEiQ7CPC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22898; AAL22898; STM4058.
GeneIDi1255585.
KEGGistm:STM4058.
PATRICi32386996. VBISalEnt20916_4278.

Phylogenomic databases

HOGENOMiHOG000269851.
KOiK07640.
OMAiEHIFRPF.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ7CPC3.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4088-MONOMER.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003660. HAMP_linker_domain.
IPR003594. HATPase_C.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720Imported.

Entry informationi

Entry nameiQ7CPC3_SALTY
AccessioniPrimary (citable) accession number: Q7CPC3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.