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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4600-MONOMER.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:STM4568
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Thymidine phosphorylasePRO_0000059064Add
BLAST

Proteomic databases

PaxDbiQ7CP66.
PRIDEiQ7CP66.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM4568.

Structurei

Secondary structure

1
440
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 129Combined sources
Helixi19 – 3012Combined sources
Helixi36 – 4914Combined sources
Helixi53 – 6513Combined sources
Helixi73 – 753Combined sources
Beta strandi81 – 866Combined sources
Helixi95 – 1039Combined sources
Turni104 – 1063Combined sources
Beta strandi108 – 1136Combined sources
Beta strandi118 – 1203Combined sources
Helixi123 – 1275Combined sources
Helixi139 – 14810Combined sources
Beta strandi150 – 1556Combined sources
Helixi163 – 17311Combined sources
Helixi180 – 19213Combined sources
Beta strandi197 – 20610Combined sources
Beta strandi209 – 2135Combined sources
Helixi214 – 23017Combined sources
Beta strandi234 – 2418Combined sources
Beta strandi246 – 2483Combined sources
Beta strandi250 – 2523Combined sources
Helixi253 – 26311Combined sources
Helixi270 – 28516Combined sources
Turni286 – 2883Combined sources
Beta strandi289 – 2924Combined sources
Helixi293 – 30513Combined sources
Helixi308 – 31912Combined sources
Helixi326 – 3338Combined sources
Beta strandi338 – 3436Combined sources
Beta strandi349 – 3546Combined sources
Helixi356 – 36611Combined sources
Beta strandi371 – 3744Combined sources
Beta strandi382 – 3854Combined sources
Beta strandi392 – 3976Combined sources
Beta strandi399 – 4068Combined sources
Helixi407 – 42014Combined sources
Beta strandi421 – 4266Combined sources
Beta strandi433 – 4386Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4X46X-ray2.20A/B1-440[»]
4XR5X-ray2.05A/B1-440[»]
4YEKX-ray2.55A/B1-440[»]
4YYYX-ray2.43A/B1-440[»]
ProteinModelPortaliQ7CP66.
SMRiQ7CP66. Positions 1-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMW. Bacteria.
COG0213. LUCA.
HOGENOMiHOG000047313.
KOiK00758.
OMAiDVWRRMI.
OrthoDBiEOG61ZTGG.
PhylomeDBiQ7CP66.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR017872. Pyrmidine_PPase_CS.
IPR000053. Thymidine/pyrmidine_PPase.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7CP66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAQEIIRK KRDGHALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD
60 70 80 90 100
MTMPERVSLT MAMRDSGTVL DWKSLNLNGP IVDKHSTGGV GDVTSLMLGP
110 120 130 140 150
MVAACGGYVP MISGRGLGHT GGTLDKLEAI PGFDIFPDDN RFREIIQDVG
160 170 180 190 200
VAIIGQTSSL APADKRFYAT RDITATVDSI PLITGSILAK KLAEGLDALV
210 220 230 240 250
MDVKVGSGAF MPTYELSEAL AEAIVGVANG AGVRTTALLT DMNQVLASSA
260 270 280 290 300
GNAVEVREAV QFLTGEYRNP RLFDVTMALC VEMLISGQLA KDDAEARAKL
310 320 330 340 350
QAVLDNGKAA EVFGRMVAAQ KGPSDFVENY DKYLPTAMLS KAVYADTEGF
360 370 380 390 400
ISAMDTRALG MAVVSMGGGR RQASDTIDYS VGFTDMARLG DSIDGQRPLA
410 420 430 440
VIHAKDEASW QEAAKAVKAA IILDDKAPAS TPSVYRRITE
Length:440
Mass (Da):47,002
Last modified:July 5, 2004 - v1
Checksum:iCF534028471AD475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23383.1.
RefSeqiNP_463424.1. NC_003197.1.
WP_000477838.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23383; AAL23383; STM4568.
GeneIDi1256094.
KEGGistm:STM4568.
PATRICi32388101. VBISalEnt20916_4810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23383.1.
RefSeqiNP_463424.1. NC_003197.1.
WP_000477838.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4X46X-ray2.20A/B1-440[»]
4XR5X-ray2.05A/B1-440[»]
4YEKX-ray2.55A/B1-440[»]
4YYYX-ray2.43A/B1-440[»]
ProteinModelPortaliQ7CP66.
SMRiQ7CP66. Positions 1-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4568.

Proteomic databases

PaxDbiQ7CP66.
PRIDEiQ7CP66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23383; AAL23383; STM4568.
GeneIDi1256094.
KEGGistm:STM4568.
PATRICi32388101. VBISalEnt20916_4810.

Phylogenomic databases

eggNOGiENOG4105CMW. Bacteria.
COG0213. LUCA.
HOGENOMiHOG000047313.
KOiK00758.
OMAiDVWRRMI.
OrthoDBiEOG61ZTGG.
PhylomeDBiQ7CP66.

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638.
BioCyciSENT99287:GCTI-4600-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR017872. Pyrmidine_PPase_CS.
IPR000053. Thymidine/pyrmidine_PPase.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiTYPH_SALTY
AccessioniPrimary (citable) accession number: Q7CP66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.