Q7CNV1 (CTRA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell cycle response regulator CtrA

Gene names

Name:	ctrA
Ordered Locus Names:	BMEI0423

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Cell cycle response regulator CtrA		PRO_0000363199
Regions
	Domain	2 – 116	115	Response regulatory
Amino acid modifications
	Modified residue	51	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7CNV1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9177C2281EC76ACE	FASTA	232	26,066
	10 20 30 40 50 60 MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL DLNLPDMSGY 70 80 90 100 110 120 EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT KPFHKDELIA RIHAIVRRSK 130 140 150 160 170 180 GHAQSVITTG DLVVNLDAKT VEVAGQRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG 190 200 210 220 230 GMDEPELKII DVFICKLRKK LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.
[2]	"Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus." Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J., Letesson J.J., De Bolle X. Mol. Microbiol. 43:945-960(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN EXPRESSSION. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL51604.1.
RefSeq	NP_539340.1. NC_003317.1.
3D structure databases
ProteinModelPortal	Q7CNV1.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEI0423.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL51604; AAL51604; BMEI0423.
GeneID	1196134.
KEGG	bme:BMEI0423.
PATRIC	17800914. VBIBruMel146950_2782.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000034815.
KO	K13584.
OMA	PDMNGHE.
ProtClustDB	CLSK863578.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTRA_BRUME

Accession

Primary (citable) accession number: Q7CNV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program