Q7CNS4 (14KL_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lectin-like protein BA14k

Gene names

Ordered Locus Names:

BMEII0552

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport By similarity.
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the BA14k family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Lectin
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 147	121	Lectin-like protein BA14k		PRO_0000361299
Regions
	Transmembrane	80 – 100	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7CNS4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7CEE6F1FB2BB38DB	FASTA	147	16,823
	10 20 30 40 50 60 MNSFRKTCAG ALALIFGATS IVPTVAAPMN MDRPAINQNV IQARAHYRPQ NYNRGHRPGY 70 80 90 100 110 120 WHGHRGYRHY RHGYRRHNDG WWYPLAAFGA GAIIGGAISQ PRPVYRAPAG SPHVQWCYSR 130 140 YKSYRASDNT FQPYNGPRKQ CRSPYSR

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53794.1.
RefSeq	NP_541530.1. NC_003318.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0552.
Proteomic databases
PRIDE	Q7CNS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53794; AAL53794; BMEII0552.
GeneID	1198324.
KEGG	bme:BMEII0552.
PATRIC	17800006. VBIBruMel146950_2337.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000274446.
OMA	YRPGYRP.
ProtClustDB	CLSK898873.
Family and domain databases
InterPro	IPR012413. BA14K. [Graphical view]
Pfam	PF07886. BA14K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

14KL_BRUME

Accession

Primary (citable) accession number: Q7CNS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program