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Protein
Submitted name:

5-Methyltetrahydrofolate--homocysteine methyltransferase

Gene

metH

Organism
Yersinia pestis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
  • methyl(III)cobalaminUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi252ZincUniRule annotation1
Metal bindingi315ZincUniRule annotation1
Metal bindingi316ZincUniRule annotation1
Metal bindingi763Cobalt (cobalamin axial ligand)UniRule annotation1
Binding sitei808CobalaminUniRule annotation1
Binding sitei950S-adenosyl-L-methionineUniRule annotation1
Binding sitei1138S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei1142Cobalamin; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandCobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
5-Methyltetrahydrofolate--homocysteine methyltransferaseImported (EC:2.1.1.13Imported)
Gene namesi
Name:metHImported
Ordered Locus Names:YPO3722Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi187410.y0020.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni838 – 839Cobalamin-bindingUniRule annotation2
Regioni1193 – 1194S-adenosyl-L-methionine bindingUniRule annotation2

Phylogenomic databases

eggNOGiENOG4105C3R. Bacteria.
COG0646. LUCA.
COG1410. LUCA.
HOGENOMiHOG000251409.
KOiK00548.

Family and domain databases

CDDicd02069. methionine_synthase_B12_BD. 1 hit.
Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 2 hits.
3.20.20.330. 1 hit.
InterProiView protein in InterPro
IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR003726. HCY_dom.
IPR033706. Met_synthase_B12-bd.
IPR011822. MetH.
IPR000489. Pterin-binding_dom.
IPR004223. VitB12-dep_Met_synth_activ_dom.
PfamiView protein in Pfam
PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiView protein in SMART
SM01018. B12-binding_2. 1 hit.
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiView protein in PROSITE
PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CLE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDTVIDNKV KELHQQLAQR ILVLDGGMGT MIQSYRLEEA DYRGARFADW
60 70 80 90 100
ASDLKGNNDL LVLSKPEVIT AIHNAYLEAG ADILETNTFN STSIAMADYQ
110 120 130 140 150
MASLSAEINY EAARLARICA DEWSARTPEK PRYVAGVLGP TNRTASISPK
160 170 180 190 200
VNDPAFRNVS FDQLVEAYRE STRALIEGGV DLIMIETVFD TLNAKAATFA
210 220 230 240 250
VESEFEVMGV LLPVMISGTI TDASGRTLSG QTTEAFYNSL RHVKPLSFGL
260 270 280 290 300
NCALGPDELR QYVAELSRIS EYYVSAHPNA GLPNAFGEYD LEAKEMAEQI
310 320 330 340 350
GEWARAGFLN IVGGCCGTTP RHIAAMVNAV AGVPPRPLPD IPVACRLAGL
360 370 380 390 400
EPLTIDANTL FVNVGERTNV TGSARFKRLI KEEKYGEALD VARQQVESGA
410 420 430 440 450
QIIDINMDEG MLDAEAAMVR FLNLIAGEPD IARVPIMIDS SRWDVIEKGL
460 470 480 490 500
KCIQGKGIVN SISMKEGVDA FIHHAKLVRR YGAAMVVMAF DETGQADTRA
510 520 530 540 550
RKIEICRRAY KILTETVGFP PEDIIFDPNI FAVATGIEEH NNYAVDFIEA
560 570 580 590 600
CADIKAELPH ALISGGVSNV SFSFRGNDPV REAIHAVFLY YAIRNGMDMG
610 620 630 640 650
IVNAGQLAIY DDLSDELRDA VEDVILNRRD DSTERLLDLA EKYRDSKSGE
660 670 680 690 700
VAIQQAEWRG WPVVKRLEYS LVKGITEFIE LDTEEARQQA DRPIEVIEGP
710 720 730 740 750
LMSGMNVVGD LFGEGKMFLP QVVKSARVMK QAVAYLEPYI EASKQKGTTA
760 770 780 790 800
GKILLATVKG DVHDIGKNIV GVVLQCNNYE IIDLGVMVPT EKILRTAREE
810 820 830 840 850
KVDIIGLSGL ITPSLDEMVN VAKEMERQGF TLPLLIGGAT TSKAHTAVKI
860 870 880 890 900
EQNYSGSTTY VSNASRSVGV VSALLSDTQR EAFVAKTRKE YETVRIQHAR
910 920 930 940 950
KKPRTPPVSL QAARNNPTVI DWENYTPPVA HKLGVQVVEA SIETLRNYID
960 970 980 990 1000
WTPFFMTWSL AGKYPRILED EVVGEEAKRL LADANALLDK LSAEDLLHPK
1010 1020 1030 1040 1050
GVVGLFPANS VGDDIEIYRD ERRDEVLAIS YHLRQQTEKT DFPNYCLADY
1060 1070 1080 1090 1100
VAPKSSGKAD YFGAFAVTGG LEEDALADAY DAQHDDYNKI MIKALSDRLA
1110 1120 1130 1140 1150
EAFAEYLHER VRKVYWGFAP NENLSNEELV RENYQGIRPA PGYPACPEHT
1160 1170 1180 1190 1200
EKGQIWQLLD VETHTGMKLT ESYAMWPGAS VSGWYFSHPD SKYFAVAQIQ
1210 1220 1230
RDQVEDYAAR KGMPTAEVER WLAPNLGYDA D
Length:1,231
Mass (Da):136,149
Last modified:July 5, 2004 - v1
Checksum:iED23132892137500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22309.1.
PIRiAB0453.
RefSeqiWP_002212080.1. NZ_LT605018.1.
YP_002348603.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83616; AAM83616; y0020.
AAS63254; AAS63254; YP_3084.
GeneIDi1176541.
KEGGiype:YPO3722.
ypj:CH55_2838.
ypk:y0020.
ypl:CH46_1365.
ypm:YP_3084.
ypv:BZ15_4014.
ypw:CH59_1634.
PATRICifig|214092.21.peg.4234.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ7CLE0_YERPE
AccessioniPrimary (citable) accession number: Q7CLE0
Secondary accession number(s): Q74RF5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported