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Q7CLE0 (Q7CLE0_YERPE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=2.1.1.13 EMBL CAL22309.1

B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metF EMBL AAM83616.1
Gene names
Name:metH EMBL AAM83616.1
Ordered Locus Names:y0020 EMBL AAM83616.1, YP_3084 EMBL AAS63254.1, YPO3722 EMBL CAL22309.1
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length1231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit By similarity. PIRSR PIRSR000381-1

Cobalamin By similarity. PIRSR PIRSR000381-2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region838 – 8392Cobalamin-binding By similarity PIRSR PIRSR000381-2
Region1193 – 11942S-adenosyl-L-methionine binding By similarity PIRSR PIRSR000381-2

Sites

Metal binding2521Zinc By similarity PIRSR PIRSR000381-1
Metal binding3151Zinc By similarity PIRSR PIRSR000381-1
Metal binding3161Zinc By similarity PIRSR PIRSR000381-1
Metal binding7631Cobalt (cobalamin axial ligand) By similarity PIRSR PIRSR000381-1
Binding site9501S-adenosyl-L-methionine By similarity PIRSR PIRSR000381-2
Binding site11381S-adenosyl-L-methionine; via carbonyl oxygen By similarity PIRSR PIRSR000381-2
Binding site11421Cobalamin; via carbonyl oxygen By similarity PIRSR PIRSR000381-2

Sequences

Sequence LengthMass (Da)Tools
Q7CLE0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: ED23132892137500

FASTA1,231136,149
        10         20         30         40         50         60 
MVDTVIDNKV KELHQQLAQR ILVLDGGMGT MIQSYRLEEA DYRGARFADW ASDLKGNNDL 

        70         80         90        100        110        120 
LVLSKPEVIT AIHNAYLEAG ADILETNTFN STSIAMADYQ MASLSAEINY EAARLARICA 

       130        140        150        160        170        180 
DEWSARTPEK PRYVAGVLGP TNRTASISPK VNDPAFRNVS FDQLVEAYRE STRALIEGGV 

       190        200        210        220        230        240 
DLIMIETVFD TLNAKAATFA VESEFEVMGV LLPVMISGTI TDASGRTLSG QTTEAFYNSL 

       250        260        270        280        290        300 
RHVKPLSFGL NCALGPDELR QYVAELSRIS EYYVSAHPNA GLPNAFGEYD LEAKEMAEQI 

       310        320        330        340        350        360 
GEWARAGFLN IVGGCCGTTP RHIAAMVNAV AGVPPRPLPD IPVACRLAGL EPLTIDANTL 

       370        380        390        400        410        420 
FVNVGERTNV TGSARFKRLI KEEKYGEALD VARQQVESGA QIIDINMDEG MLDAEAAMVR 

       430        440        450        460        470        480 
FLNLIAGEPD IARVPIMIDS SRWDVIEKGL KCIQGKGIVN SISMKEGVDA FIHHAKLVRR 

       490        500        510        520        530        540 
YGAAMVVMAF DETGQADTRA RKIEICRRAY KILTETVGFP PEDIIFDPNI FAVATGIEEH 

       550        560        570        580        590        600 
NNYAVDFIEA CADIKAELPH ALISGGVSNV SFSFRGNDPV REAIHAVFLY YAIRNGMDMG 

       610        620        630        640        650        660 
IVNAGQLAIY DDLSDELRDA VEDVILNRRD DSTERLLDLA EKYRDSKSGE VAIQQAEWRG 

       670        680        690        700        710        720 
WPVVKRLEYS LVKGITEFIE LDTEEARQQA DRPIEVIEGP LMSGMNVVGD LFGEGKMFLP 

       730        740        750        760        770        780 
QVVKSARVMK QAVAYLEPYI EASKQKGTTA GKILLATVKG DVHDIGKNIV GVVLQCNNYE 

       790        800        810        820        830        840 
IIDLGVMVPT EKILRTAREE KVDIIGLSGL ITPSLDEMVN VAKEMERQGF TLPLLIGGAT 

       850        860        870        880        890        900 
TSKAHTAVKI EQNYSGSTTY VSNASRSVGV VSALLSDTQR EAFVAKTRKE YETVRIQHAR 

       910        920        930        940        950        960 
KKPRTPPVSL QAARNNPTVI DWENYTPPVA HKLGVQVVEA SIETLRNYID WTPFFMTWSL 

       970        980        990       1000       1010       1020 
AGKYPRILED EVVGEEAKRL LADANALLDK LSAEDLLHPK GVVGLFPANS VGDDIEIYRD 

      1030       1040       1050       1060       1070       1080 
ERRDEVLAIS YHLRQQTEKT DFPNYCLADY VAPKSSGKAD YFGAFAVTGG LEEDALADAY 

      1090       1100       1110       1120       1130       1140 
DAQHDDYNKI MIKALSDRLA EAFAEYLHER VRKVYWGFAP NENLSNEELV RENYQGIRPA 

      1150       1160       1170       1180       1190       1200 
PGYPACPEHT EKGQIWQLLD VETHTGMKLT ESYAMWPGAS VSGWYFSHPD SKYFAVAQIQ 

      1210       1220       1230 
RDQVEDYAAR KGMPTAEVER WLAPNLGYDA D 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis and CO92 EMBL CAL22309.1.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM EMBL AAM83616.1 and KIM10+ / Biovar Mediaevalis.
[3]"Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
Delihas N.
BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CO92 EMBL CAL22309.1.
[4]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 EMBL AAS63254.1 and 91001 / Biovar Mediaevalis.
[5]"Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 91001 EMBL AAS63254.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009952 Genomic DNA. Translation: AAM83616.1.
AE017042 Genomic DNA. Translation: AAS63254.1.
AL590842 Genomic DNA. Translation: CAL22309.1.
PIRAB0453.
RefSeqNP_667365.1. NC_004088.1.
NP_994377.1. NC_005810.1.
YP_002348603.1. NC_003143.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING214092.YPO3722.

Protocols and materials databases

DNASU1144967.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM83616; AAM83616; y0020.
AAS63254; AAS63254; YP_3084.
GeneID1144967.
1176541.
2764231.
KEGGype:YPO3722.
ypk:y0020.
ypm:YP_3084.

Phylogenomic databases

HOGENOMHOG000251409.
KOK00548.
OMASMKEGEA.
OrthoDBEOG6091CH.
ProtClustDBPRK09490.

Enzyme and pathway databases

BioCycYPES214092:GKDD-3678-MONOMER.

Family and domain databases

Gene3D1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF000381. MetH. 1 hit.
SMARTSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsTIGR02082. metH. 1 hit.
PROSITEPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7CLE0_YERPE
AccessionPrimary (citable) accession number: Q7CLE0
Secondary accession number(s): Q74RF5
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)