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Q7CLE0

- Q7CLE0_YERPE

UniProt

Q7CLE0 - Q7CLE0_YERPE

Protein
Submitted name:

5-Methyltetrahydrofolate--homocysteine methyltransferase

Gene

metH

Organism
Yersinia pestis
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation
    Cobalamin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi252 – 2521ZincUniRule annotation
    Metal bindingi315 – 3151ZincUniRule annotation
    Metal bindingi316 – 3161ZincUniRule annotation
    Metal bindingi763 – 7631Cobalt (cobalamin axial ligand)UniRule annotation
    Binding sitei950 – 9501S-adenosyl-L-methionine
    Binding sitei1138 – 11381S-adenosyl-L-methionine; via carbonyl oxygen
    Binding sitei1142 – 11421Cobalamin; via carbonyl oxygen

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. methionine synthase activity Source: UniProtKB-EC
    3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. pteridine-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Keywords - Ligandi

    CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-3678-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    5-Methyltetrahydrofolate--homocysteine methyltransferaseImported (EC:2.1.1.13Imported)
    Submitted name:
    B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metFImported
    Gene namesi
    Name:metHImported
    Ordered Locus Names:y0020Imported, YP_3084Imported, YPO3722Imported
    OrganismiYersinia pestisImported
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001019: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi214092.YPO3722.

    Structurei

    3D structure databases

    SMRiQ7CLE0. Positions 655-1231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni838 – 8392Cobalamin-binding
    Regioni1193 – 11942S-adenosyl-L-methionine binding

    Phylogenomic databases

    HOGENOMiHOG000251409.
    KOiK00548.
    OMAiLTEHYAM.
    OrthoDBiEOG6091CH.

    Family and domain databases

    Gene3Di1.10.1240.10. 1 hit.
    3.10.196.10. 1 hit.
    3.20.20.20. 1 hit.
    3.20.20.330. 1 hit.
    3.40.50.280. 1 hit.
    InterProiIPR003759. Cbl-bd_cap.
    IPR006158. Cobalamin-bd.
    IPR011005. Dihydropteroate_synth-like.
    IPR011822. MetH.
    IPR000489. Pterin-binding.
    IPR003726. S_MeTrfase.
    IPR004223. VitB12-dep_Met_synth_activ_dom.
    [Graphical view]
    PfamiPF02310. B12-binding. 1 hit.
    PF02607. B12-binding_2. 1 hit.
    PF02965. Met_synt_B12. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    PF02574. S-methyl_trans. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000381. MetH. 1 hit.
    SMARTiSM01018. B12-binding_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47644. SSF47644. 1 hit.
    SSF51717. SSF51717. 1 hit.
    SSF52242. SSF52242. 1 hit.
    SSF56507. SSF56507. 1 hit.
    SSF82282. SSF82282. 1 hit.
    TIGRFAMsiTIGR02082. metH. 1 hit.
    PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
    PS51332. B12_BINDING. 1 hit.
    PS51337. B12_BINDING_NTER. 1 hit.
    PS50970. HCY. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7CLE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDTVIDNKV KELHQQLAQR ILVLDGGMGT MIQSYRLEEA DYRGARFADW     50
    ASDLKGNNDL LVLSKPEVIT AIHNAYLEAG ADILETNTFN STSIAMADYQ 100
    MASLSAEINY EAARLARICA DEWSARTPEK PRYVAGVLGP TNRTASISPK 150
    VNDPAFRNVS FDQLVEAYRE STRALIEGGV DLIMIETVFD TLNAKAATFA 200
    VESEFEVMGV LLPVMISGTI TDASGRTLSG QTTEAFYNSL RHVKPLSFGL 250
    NCALGPDELR QYVAELSRIS EYYVSAHPNA GLPNAFGEYD LEAKEMAEQI 300
    GEWARAGFLN IVGGCCGTTP RHIAAMVNAV AGVPPRPLPD IPVACRLAGL 350
    EPLTIDANTL FVNVGERTNV TGSARFKRLI KEEKYGEALD VARQQVESGA 400
    QIIDINMDEG MLDAEAAMVR FLNLIAGEPD IARVPIMIDS SRWDVIEKGL 450
    KCIQGKGIVN SISMKEGVDA FIHHAKLVRR YGAAMVVMAF DETGQADTRA 500
    RKIEICRRAY KILTETVGFP PEDIIFDPNI FAVATGIEEH NNYAVDFIEA 550
    CADIKAELPH ALISGGVSNV SFSFRGNDPV REAIHAVFLY YAIRNGMDMG 600
    IVNAGQLAIY DDLSDELRDA VEDVILNRRD DSTERLLDLA EKYRDSKSGE 650
    VAIQQAEWRG WPVVKRLEYS LVKGITEFIE LDTEEARQQA DRPIEVIEGP 700
    LMSGMNVVGD LFGEGKMFLP QVVKSARVMK QAVAYLEPYI EASKQKGTTA 750
    GKILLATVKG DVHDIGKNIV GVVLQCNNYE IIDLGVMVPT EKILRTAREE 800
    KVDIIGLSGL ITPSLDEMVN VAKEMERQGF TLPLLIGGAT TSKAHTAVKI 850
    EQNYSGSTTY VSNASRSVGV VSALLSDTQR EAFVAKTRKE YETVRIQHAR 900
    KKPRTPPVSL QAARNNPTVI DWENYTPPVA HKLGVQVVEA SIETLRNYID 950
    WTPFFMTWSL AGKYPRILED EVVGEEAKRL LADANALLDK LSAEDLLHPK 1000
    GVVGLFPANS VGDDIEIYRD ERRDEVLAIS YHLRQQTEKT DFPNYCLADY 1050
    VAPKSSGKAD YFGAFAVTGG LEEDALADAY DAQHDDYNKI MIKALSDRLA 1100
    EAFAEYLHER VRKVYWGFAP NENLSNEELV RENYQGIRPA PGYPACPEHT 1150
    EKGQIWQLLD VETHTGMKLT ESYAMWPGAS VSGWYFSHPD SKYFAVAQIQ 1200
    RDQVEDYAAR KGMPTAEVER WLAPNLGYDA D 1231
    Length:1,231
    Mass (Da):136,149
    Last modified:July 5, 2004 - v1
    Checksum:iED23132892137500
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009952 Genomic DNA. Translation: AAM83616.1.
    AE017042 Genomic DNA. Translation: AAS63254.1.
    AL590842 Genomic DNA. Translation: CAL22309.1.
    PIRiAB0453.
    RefSeqiNP_667365.1. NC_004088.1.
    NP_994377.1. NC_005810.1.
    YP_002348603.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM83616; AAM83616; y0020.
    AAS63254; AAS63254; YP_3084.
    GeneIDi1144967.
    1176541.
    2764231.
    KEGGiype:YPO3722.
    ypk:y0020.
    ypm:YP_3084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009952 Genomic DNA. Translation: AAM83616.1 .
    AE017042 Genomic DNA. Translation: AAS63254.1 .
    AL590842 Genomic DNA. Translation: CAL22309.1 .
    PIRi AB0453.
    RefSeqi NP_667365.1. NC_004088.1.
    NP_994377.1. NC_005810.1.
    YP_002348603.1. NC_003143.1.

    3D structure databases

    SMRi Q7CLE0. Positions 655-1231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO3722.

    Protocols and materials databases

    DNASUi 1144967.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM83616 ; AAM83616 ; y0020 .
    AAS63254 ; AAS63254 ; YP_3084 .
    GeneIDi 1144967.
    1176541.
    2764231.
    KEGGi ype:YPO3722.
    ypk:y0020.
    ypm:YP_3084.

    Phylogenomic databases

    HOGENOMi HOG000251409.
    KOi K00548.
    OMAi LTEHYAM.
    OrthoDBi EOG6091CH.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-3678-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1240.10. 1 hit.
    3.10.196.10. 1 hit.
    3.20.20.20. 1 hit.
    3.20.20.330. 1 hit.
    3.40.50.280. 1 hit.
    InterProi IPR003759. Cbl-bd_cap.
    IPR006158. Cobalamin-bd.
    IPR011005. Dihydropteroate_synth-like.
    IPR011822. MetH.
    IPR000489. Pterin-binding.
    IPR003726. S_MeTrfase.
    IPR004223. VitB12-dep_Met_synth_activ_dom.
    [Graphical view ]
    Pfami PF02310. B12-binding. 1 hit.
    PF02607. B12-binding_2. 1 hit.
    PF02965. Met_synt_B12. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    PF02574. S-methyl_trans. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000381. MetH. 1 hit.
    SMARTi SM01018. B12-binding_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47644. SSF47644. 1 hit.
    SSF51717. SSF51717. 1 hit.
    SSF52242. SSF52242. 1 hit.
    SSF56507. SSF56507. 1 hit.
    SSF82282. SSF82282. 1 hit.
    TIGRFAMsi TIGR02082. metH. 1 hit.
    PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
    PS51332. B12_BINDING. 1 hit.
    PS51337. B12_BINDING_NTER. 1 hit.
    PS50970. HCY. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO92Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIMImported.
    3. "Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
      Delihas N.
      BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CO92Imported.
    4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001Imported and 91001 / Biovar MediaevalisImported.
    5. "Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
      Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
      J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 91001Imported.

    Entry informationi

    Entry nameiQ7CLE0_YERPE
    AccessioniPrimary (citable) accession number: Q7CLE0
    Secondary accession number(s): Q74RF5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3