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Q7CLE0

- Q7CLE0_YERPE

UniProt

Q7CLE0 - Q7CLE0_YERPE

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Protein
Submitted name:

5-Methyltetrahydrofolate--homocysteine methyltransferase

Gene

metH

Organism
Yersinia pestis
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521ZincUniRule annotation
Metal bindingi315 – 3151ZincUniRule annotation
Metal bindingi316 – 3161ZincUniRule annotation
Metal bindingi763 – 7631Cobalt (cobalamin axial ligand)UniRule annotation
Binding sitei950 – 9501S-adenosyl-L-methionine
Binding sitei1138 – 11381S-adenosyl-L-methionine; via carbonyl oxygen
Binding sitei1142 – 11421Cobalamin; via carbonyl oxygen

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. methionine synthase activity Source: UniProtKB-EC
  3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. pteridine-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

CobaltUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3678-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
5-Methyltetrahydrofolate--homocysteine methyltransferaseImported (EC:2.1.1.13Imported)
Submitted name:
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metFImported
Gene namesi
Name:metHImported
Ordered Locus Names:y0020Imported, YP_3084Imported, YPO3722Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001019: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO3722.

Structurei

3D structure databases

ProteinModelPortaliQ7CLE0.
SMRiQ7CLE0. Positions 655-1231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni838 – 8392Cobalamin-binding
Regioni1193 – 11942S-adenosyl-L-methionine binding

Phylogenomic databases

HOGENOMiHOG000251409.
KOiK00548.
OMAiLTEHYAM.
OrthoDBiEOG6091CH.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7CLE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDTVIDNKV KELHQQLAQR ILVLDGGMGT MIQSYRLEEA DYRGARFADW
60 70 80 90 100
ASDLKGNNDL LVLSKPEVIT AIHNAYLEAG ADILETNTFN STSIAMADYQ
110 120 130 140 150
MASLSAEINY EAARLARICA DEWSARTPEK PRYVAGVLGP TNRTASISPK
160 170 180 190 200
VNDPAFRNVS FDQLVEAYRE STRALIEGGV DLIMIETVFD TLNAKAATFA
210 220 230 240 250
VESEFEVMGV LLPVMISGTI TDASGRTLSG QTTEAFYNSL RHVKPLSFGL
260 270 280 290 300
NCALGPDELR QYVAELSRIS EYYVSAHPNA GLPNAFGEYD LEAKEMAEQI
310 320 330 340 350
GEWARAGFLN IVGGCCGTTP RHIAAMVNAV AGVPPRPLPD IPVACRLAGL
360 370 380 390 400
EPLTIDANTL FVNVGERTNV TGSARFKRLI KEEKYGEALD VARQQVESGA
410 420 430 440 450
QIIDINMDEG MLDAEAAMVR FLNLIAGEPD IARVPIMIDS SRWDVIEKGL
460 470 480 490 500
KCIQGKGIVN SISMKEGVDA FIHHAKLVRR YGAAMVVMAF DETGQADTRA
510 520 530 540 550
RKIEICRRAY KILTETVGFP PEDIIFDPNI FAVATGIEEH NNYAVDFIEA
560 570 580 590 600
CADIKAELPH ALISGGVSNV SFSFRGNDPV REAIHAVFLY YAIRNGMDMG
610 620 630 640 650
IVNAGQLAIY DDLSDELRDA VEDVILNRRD DSTERLLDLA EKYRDSKSGE
660 670 680 690 700
VAIQQAEWRG WPVVKRLEYS LVKGITEFIE LDTEEARQQA DRPIEVIEGP
710 720 730 740 750
LMSGMNVVGD LFGEGKMFLP QVVKSARVMK QAVAYLEPYI EASKQKGTTA
760 770 780 790 800
GKILLATVKG DVHDIGKNIV GVVLQCNNYE IIDLGVMVPT EKILRTAREE
810 820 830 840 850
KVDIIGLSGL ITPSLDEMVN VAKEMERQGF TLPLLIGGAT TSKAHTAVKI
860 870 880 890 900
EQNYSGSTTY VSNASRSVGV VSALLSDTQR EAFVAKTRKE YETVRIQHAR
910 920 930 940 950
KKPRTPPVSL QAARNNPTVI DWENYTPPVA HKLGVQVVEA SIETLRNYID
960 970 980 990 1000
WTPFFMTWSL AGKYPRILED EVVGEEAKRL LADANALLDK LSAEDLLHPK
1010 1020 1030 1040 1050
GVVGLFPANS VGDDIEIYRD ERRDEVLAIS YHLRQQTEKT DFPNYCLADY
1060 1070 1080 1090 1100
VAPKSSGKAD YFGAFAVTGG LEEDALADAY DAQHDDYNKI MIKALSDRLA
1110 1120 1130 1140 1150
EAFAEYLHER VRKVYWGFAP NENLSNEELV RENYQGIRPA PGYPACPEHT
1160 1170 1180 1190 1200
EKGQIWQLLD VETHTGMKLT ESYAMWPGAS VSGWYFSHPD SKYFAVAQIQ
1210 1220 1230
RDQVEDYAAR KGMPTAEVER WLAPNLGYDA D
Length:1,231
Mass (Da):136,149
Last modified:July 5, 2004 - v1
Checksum:iED23132892137500
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009952 Genomic DNA. Translation: AAM83616.1.
AE017042 Genomic DNA. Translation: AAS63254.1.
AL590842 Genomic DNA. Translation: CAL22309.1.
PIRiAB0453.
RefSeqiNP_667365.1. NC_004088.1.
NP_994377.1. NC_005810.1.
YP_002348603.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83616; AAM83616; y0020.
AAS63254; AAS63254; YP_3084.
GeneIDi1144967.
1176541.
2764231.
KEGGiype:YPO3722.
ypk:y0020.
ypm:YP_3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009952 Genomic DNA. Translation: AAM83616.1 .
AE017042 Genomic DNA. Translation: AAS63254.1 .
AL590842 Genomic DNA. Translation: CAL22309.1 .
PIRi AB0453.
RefSeqi NP_667365.1. NC_004088.1.
NP_994377.1. NC_005810.1.
YP_002348603.1. NC_003143.1.

3D structure databases

ProteinModelPortali Q7CLE0.
SMRi Q7CLE0. Positions 655-1231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO3722.

Protocols and materials databases

DNASUi 1144967.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM83616 ; AAM83616 ; y0020 .
AAS63254 ; AAS63254 ; YP_3084 .
GeneIDi 1144967.
1176541.
2764231.
KEGGi ype:YPO3722.
ypk:y0020.
ypm:YP_3084.

Phylogenomic databases

HOGENOMi HOG000251409.
KOi K00548.
OMAi LTEHYAM.
OrthoDBi EOG6091CH.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-3678-MONOMER.

Family and domain databases

Gene3Di 1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProi IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view ]
Pfami PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF000381. MetH. 1 hit.
SMARTi SM01018. B12-binding_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsi TIGR02082. metH. 1 hit.
PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO92Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIMImported.
  3. "Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
    Delihas N.
    BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CO92Imported.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001Imported and 91001 / Biovar MediaevalisImported.
  5. "Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
    Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
    J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 91001Imported.

Entry informationi

Entry nameiQ7CLE0_YERPE
AccessioniPrimary (citable) accession number: Q7CLE0
Secondary accession number(s): Q74RF5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3