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Q7CLE0

- Q7CLE0_YERPE

UniProt

Q7CLE0 - Q7CLE0_YERPE

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Protein
Submitted name:

5-Methyltetrahydrofolate--homocysteine methyltransferase

Gene
metH, y0020, YP_3084, YPO3722
Organism
Yersinia pestis
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation
Cobalamin By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521Zinc By similarityUniRule annotation
Metal bindingi315 – 3151Zinc By similarityUniRule annotation
Metal bindingi316 – 3161Zinc By similarityUniRule annotation
Metal bindingi763 – 7631Cobalt (cobalamin axial ligand) By similarityUniRule annotation
Binding sitei950 – 9501S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei1138 – 11381S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei1142 – 11421Cobalamin; via carbonyl oxygen By similarityUniRule annotation

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. methionine synthase activity Source: UniProtKB-EC
  3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. pteridine-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3678-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
5-Methyltetrahydrofolate--homocysteine methyltransferaseImported (EC:2.1.1.13Imported)
Submitted name:
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase, repressor of metE and metFImported
Gene namesi
Name:metHImported
Ordered Locus Names:y0020Imported, YP_3084Imported, YPO3722Imported
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000002490: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO3722.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni838 – 8392Cobalamin-binding By similarityUniRule annotation
Regioni1193 – 11942S-adenosyl-L-methionine binding By similarityUniRule annotation

Phylogenomic databases

HOGENOMiHOG000251409.
KOiK00548.
OMAiLTEHYAM.
OrthoDBiEOG6091CH.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7CLE0-1 [UniParc]FASTAAdd to Basket

« Hide

MVDTVIDNKV KELHQQLAQR ILVLDGGMGT MIQSYRLEEA DYRGARFADW     50
ASDLKGNNDL LVLSKPEVIT AIHNAYLEAG ADILETNTFN STSIAMADYQ 100
MASLSAEINY EAARLARICA DEWSARTPEK PRYVAGVLGP TNRTASISPK 150
VNDPAFRNVS FDQLVEAYRE STRALIEGGV DLIMIETVFD TLNAKAATFA 200
VESEFEVMGV LLPVMISGTI TDASGRTLSG QTTEAFYNSL RHVKPLSFGL 250
NCALGPDELR QYVAELSRIS EYYVSAHPNA GLPNAFGEYD LEAKEMAEQI 300
GEWARAGFLN IVGGCCGTTP RHIAAMVNAV AGVPPRPLPD IPVACRLAGL 350
EPLTIDANTL FVNVGERTNV TGSARFKRLI KEEKYGEALD VARQQVESGA 400
QIIDINMDEG MLDAEAAMVR FLNLIAGEPD IARVPIMIDS SRWDVIEKGL 450
KCIQGKGIVN SISMKEGVDA FIHHAKLVRR YGAAMVVMAF DETGQADTRA 500
RKIEICRRAY KILTETVGFP PEDIIFDPNI FAVATGIEEH NNYAVDFIEA 550
CADIKAELPH ALISGGVSNV SFSFRGNDPV REAIHAVFLY YAIRNGMDMG 600
IVNAGQLAIY DDLSDELRDA VEDVILNRRD DSTERLLDLA EKYRDSKSGE 650
VAIQQAEWRG WPVVKRLEYS LVKGITEFIE LDTEEARQQA DRPIEVIEGP 700
LMSGMNVVGD LFGEGKMFLP QVVKSARVMK QAVAYLEPYI EASKQKGTTA 750
GKILLATVKG DVHDIGKNIV GVVLQCNNYE IIDLGVMVPT EKILRTAREE 800
KVDIIGLSGL ITPSLDEMVN VAKEMERQGF TLPLLIGGAT TSKAHTAVKI 850
EQNYSGSTTY VSNASRSVGV VSALLSDTQR EAFVAKTRKE YETVRIQHAR 900
KKPRTPPVSL QAARNNPTVI DWENYTPPVA HKLGVQVVEA SIETLRNYID 950
WTPFFMTWSL AGKYPRILED EVVGEEAKRL LADANALLDK LSAEDLLHPK 1000
GVVGLFPANS VGDDIEIYRD ERRDEVLAIS YHLRQQTEKT DFPNYCLADY 1050
VAPKSSGKAD YFGAFAVTGG LEEDALADAY DAQHDDYNKI MIKALSDRLA 1100
EAFAEYLHER VRKVYWGFAP NENLSNEELV RENYQGIRPA PGYPACPEHT 1150
EKGQIWQLLD VETHTGMKLT ESYAMWPGAS VSGWYFSHPD SKYFAVAQIQ 1200
RDQVEDYAAR KGMPTAEVER WLAPNLGYDA D 1231
Length:1,231
Mass (Da):136,149
Last modified:July 5, 2004 - v1
Checksum:iED23132892137500
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009952 Genomic DNA. Translation: AAM83616.1.
AE017042 Genomic DNA. Translation: AAS63254.1.
AL590842 Genomic DNA. Translation: CAL22309.1.
PIRiAB0453.
RefSeqiNP_667365.1. NC_004088.1.
NP_994377.1. NC_005810.1.
YP_002348603.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83616; AAM83616; y0020.
AAS63254; AAS63254; YP_3084.
GeneIDi1144967.
1176541.
2764231.
KEGGiype:YPO3722.
ypk:y0020.
ypm:YP_3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009952 Genomic DNA. Translation: AAM83616.1 .
AE017042 Genomic DNA. Translation: AAS63254.1 .
AL590842 Genomic DNA. Translation: CAL22309.1 .
PIRi AB0453.
RefSeqi NP_667365.1. NC_004088.1.
NP_994377.1. NC_005810.1.
YP_002348603.1. NC_003143.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 214092.YPO3722.

Protocols and materials databases

DNASUi 1144967.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM83616 ; AAM83616 ; y0020 .
AAS63254 ; AAS63254 ; YP_3084 .
GeneIDi 1144967.
1176541.
2764231.
KEGGi ype:YPO3722.
ypk:y0020.
ypm:YP_3084.

Phylogenomic databases

HOGENOMi HOG000251409.
KOi K00548.
OMAi LTEHYAM.
OrthoDBi EOG6091CH.

Enzyme and pathway databases

BioCyci YPES214092:GKDD-3678-MONOMER.

Family and domain databases

Gene3Di 1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProi IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view ]
Pfami PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF000381. MetH. 1 hit.
SMARTi SM01018. B12-binding_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsi TIGR02082. metH. 1 hit.
PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis and CO92Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIMImported and KIM10+ / Biovar Mediaevalis.
  3. "Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
    Delihas N.
    BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CO92Imported.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001Imported and 91001 / Biovar Mediaevalis.
  5. "Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
    Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
    J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 91001Imported.

Entry informationi

Entry nameiQ7CLE0_YERPE
AccessioniPrimary (citable) accession number: Q7CLE0
Secondary accession number(s): Q74RF5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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