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Protein

Deoxyribose-phosphate aldolase

Gene

YPO3622

Organism
Yersinia pestis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.SAAS annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.SAAS annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (YPO3622), Deoxyribose-phosphate aldolase (deoC), Deoxyribose-phosphate aldolase 1 (deoC1), Deoxyribose-phosphate aldolase (deoC), Deoxyribose-phosphate aldolase (deoC3), Deoxyribose-phosphate aldolase 2 (deoC2)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseSAAS annotationImported
LigandSchiff baseSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseSAAS annotation (EC:4.1.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:YPO3622Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi187410.y0247.

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108PMK. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241645.
KOiK01619.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
PANTHERiPTHR10889. PTHR10889. 1 hit.
PTHR10889:SF9. PTHR10889:SF9. 1 hit.
PfamiView protein in Pfam
PF01791. DeoC. 1 hit.
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiView protein in SMART
SM01133. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CL43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDFNDPRQV AKAIQFTNVN ADLTREGVIK HLNICLEYQF DAAMIAPCWV
60 70 80 90 100
YLAKDVLKGS GVRVATTVNF PQANDTTAMK VAIVRELAKE GADEFDFPPN
110 120 130 140 150
PGFLLGGLDE LYFNELKEVT HIAHDLGMKV KAMLEFGFIT EEAMKIKATR
160 170 180 190 200
YAYEAGIDWV KQSSGWGKGG CAATVEDVQL LKANIQAPCR VKVSGKVNTL
210 220 230
EKMKEMFLAG AELVGTSSGP ELVKGLTGDI NAY
Length:233
Mass (Da):25,470
Last modified:July 5, 2004 - v1
Checksum:i9E3D42F7539138B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22210.1.
PIRiAG0440.
RefSeqiWP_002210030.1. NZ_LT605018.1.
YP_002348507.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83841; AAM83841; y0247.
AAS64069; AAS64069; YP_3925.
GeneIDi1176442.
KEGGiype:YPO3622.
ypj:CH55_2579.
ypk:y0247.
ypl:CH46_1417.
ypm:YP_3925.
ypv:BZ15_4066.
ypw:CH59_2377.
PATRICifig|214092.21.peg.4122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590842 Genomic DNA. Translation: CAL22210.1.
PIRiAG0440.
RefSeqiWP_002210030.1. NZ_LT605018.1.
YP_002348507.1. NC_003143.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187410.y0247.

Protocols and materials databases

DNASUi1145194.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM83841; AAM83841; y0247.
AAS64069; AAS64069; YP_3925.
GeneIDi1176442.
KEGGiype:YPO3622.
ypj:CH55_2579.
ypk:y0247.
ypl:CH46_1417.
ypm:YP_3925.
ypv:BZ15_4066.
ypw:CH59_2377.
PATRICifig|214092.21.peg.4122.

Phylogenomic databases

eggNOGiENOG4108PMK. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241645.
KOiK01619.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
PANTHERiPTHR10889. PTHR10889. 1 hit.
PTHR10889:SF9. PTHR10889:SF9. 1 hit.
PfamiView protein in Pfam
PF01791. DeoC. 1 hit.
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiView protein in SMART
SM01133. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ7CL43_YERPE
AccessioniPrimary (citable) accession number: Q7CL43
Secondary accession number(s): Q74PI2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.