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Protein
Submitted name:

Heme-binding A family protein

Gene

hasA

Organism
Yersinia pestis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Iron (heme axial ligand)Combined sources

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

HemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3900-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Heme-binding A family proteinImported
Submitted name:
Hemophore HasAImported
Submitted name:
Secreted hemophoreImported
Gene namesi
Name:hasAImported
Ordered Locus Names:y0314Imported, YP_3127Imported, YPO3922Imported
ORF Names:DJ56_796Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi214092.YPO3922.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JERX-ray1.10A1-193[»]
4JESX-ray1.60A/B1-193[»]
4JETX-ray2.20A/B/C/D/E/F/G/H/I/J1-193[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000219133.
KOiK12545.
OMAiPQHTFYG.
OrthoDBiEOG6CVVBX.

Family and domain databases

Gene3Di3.30.1500.10. 1 hit.
InterProiIPR010495. HasA_haem-bd.
[Graphical view]
PfamiPF06438. HasA. 1 hit.
[Graphical view]
PIRSFiPIRSF019876. HasA. 1 hit.
SUPFAMiSSF54621. SSF54621. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CL15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTIQYNSN YADYSISSYL REWANNFGDI DQAPAETKDR GSFSGSSTLF
60 70 80 90 100
SGTQYAIGSS HSNPEGMIAE GDLKYSFMPQ HTFHGQIDTL QFGKDLATNA
110 120 130 140 150
GGPSAGKHLE KIDITFNELD LSGEFDSGKS MTENHQGDMH KSVRGLMKGN
160 170 180 190 200
PDPMLEVMKA KGINVDTAFK DLSIASQYPD SGYMSDAPMV DTVGVVDCHD

MLLAA
Length:205
Mass (Da):22,231
Last modified:July 5, 2004 - v1
Checksum:i8B4A2C178B6B2EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009952 Genomic DNA. Translation: AAM83905.1.
AE017042 Genomic DNA. Translation: AAS63297.1.
AL590842 Genomic DNA. Translation: CAL22506.1.
JPMB01000024 Genomic DNA. Translation: KGA52902.1.
PIRiAG0477.
RefSeqiNP_667654.1. NC_004088.1.
NP_994420.1. NC_005810.1.
WP_002209484.1. NZ_KN150726.1.
YP_002348796.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83905; AAM83905; y0314.
AAS63297; AAS63297; YP_3127.
GeneIDi1145261.
1176764.
2766056.
KEGGiype:YPO3922.
ypk:y0314.
ypm:YP_3127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009952 Genomic DNA. Translation: AAM83905.1.
AE017042 Genomic DNA. Translation: AAS63297.1.
AL590842 Genomic DNA. Translation: CAL22506.1.
JPMB01000024 Genomic DNA. Translation: KGA52902.1.
PIRiAG0477.
RefSeqiNP_667654.1. NC_004088.1.
NP_994420.1. NC_005810.1.
WP_002209484.1. NZ_KN150726.1.
YP_002348796.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JERX-ray1.10A1-193[»]
4JESX-ray1.60A/B1-193[»]
4JETX-ray2.20A/B/C/D/E/F/G/H/I/J1-193[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO3922.

Protocols and materials databases

DNASUi1145261.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM83905; AAM83905; y0314.
AAS63297; AAS63297; YP_3127.
GeneIDi1145261.
1176764.
2766056.
KEGGiype:YPO3922.
ypk:y0314.
ypm:YP_3127.

Phylogenomic databases

HOGENOMiHOG000219133.
KOiK12545.
OMAiPQHTFYG.
OrthoDBiEOG6CVVBX.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3900-MONOMER.

Family and domain databases

Gene3Di3.30.1500.10. 1 hit.
InterProiIPR010495. HasA_haem-bd.
[Graphical view]
PfamiPF06438. HasA. 1 hit.
[Graphical view]
PIRSFiPIRSF019876. HasA. 1 hit.
SUPFAMiSSF54621. SSF54621. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar OrientalisImported and CO92Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIMImported and KIM10+ / Biovar MediaevalisImported.
  3. "Annotation and evolutionary relationships of a small regulatory RNA gene micF and its target ompF in Yersinia species."
    Delihas N.
    BMC Microbiol. 3:13-13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CO92Imported.
  4. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001Imported and 91001 / Biovar MediaevalisImported.
  5. "Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus."
    Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.
    J. Bacteriol. 186:5147-5152(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 91001Imported.
  6. "The hemophore HasA from Yersinia pestis (HasAyp) coordinates hemin with a single residue, Tyr75, and with minimal conformational change."
    Kumar R., Lovell S., Matsumura H., Battaile K.P., Moenne-Loccoz P., Rivera M.
    Biochemistry 52:2705-2707(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 1-193 IN COMPLEX WITH HEME.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Colorado 92Imported.

Entry informationi

Entry nameiQ7CL15_YERPE
AccessioniPrimary (citable) accession number: Q7CL15
Secondary accession number(s): Q74RD4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.