Q7CKG8 (PHNN_YERPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose 1,5-bisphosphate phosphokinase PhnN
EC=2.7.4.23

Alternative name(s):
Ribose 1,5-bisphosphokinase

Gene names

Name:	phnN
Ordered Locus Names:	YPO3464, y0721, YP_0619

Organism

Yersinia pestis [Reference proteome] [HAMAP]

Taxonomic identifier

632 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) By similarity. HAMAP-Rule MF_00836
Catalytic activity	ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00836
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 3/3. HAMAP-Rule MF_00836
Sequence similarities	Belongs to the ribose 1,5-bisphosphokinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	5-phosphoribose 1-diphosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP organic phosphonate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ribose 1,5-bisphosphate phosphokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Ribose 1,5-bisphosphate phosphokinase PhnN HAMAP-Rule MF_00836		PRO_0000412803
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7CKG8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EE382D52E6D4C527	FASTA	193	21,918
	10 20 30 40 50 60 MARLIYLMGP SGAGKDCLLS ALRNATPQNR VVAHRYITRP ADAGAENHVA LSKQEFIQRA 70 80 90 100 110 120 EQGLFALHWQ AHQHCYAIGI EINLWLQHGL DVLVNGSRAY LPEAQRRYRH QLLPLCLTVS 130 140 150 160 170 180 PAILAQRLRQ RGRENSEQID ARLQRAQHYQ QQLPSHCLQL CNDGELQHTL NQLQQLLTLD 190 TPLSDPVEDK PCN

References

[1]	"Genome sequence of Yersinia pestis KIM." Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. , Matson J.S., Blattner F.R., Perry R.D. J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KIM10+ / Biovar Mediaevalis.
[2]	"Genome sequence of Yersinia pestis, the causative agent of plague." Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G. Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CO-92 / Biovar Orientalis.
[3]	"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans." Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R. DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009952 Genomic DNA. Translation: AAM84309.1. AE017042 Genomic DNA. Translation: AAS60888.1. AL590842 Genomic DNA. Translation: CAL22052.1.
PIR	AI0420.
RefSeq	NP_668058.1. NC_004088.1. NP_992011.1. NC_005810.1. YP_002348353.1. NC_003143.1.
3D structure databases
ProteinModelPortal	Q7CKG8.
ModBase	Search...
Protein-protein interaction databases
STRING	214092.YPO3464.
Protocols and materials databases
DNASU	1145668.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM84309; AAM84309; y0721. AAS60888; AAS60888; YP_0619.
GeneID	1145668. 1176281. 2766377.
KEGG	ype:YPO3464. ypk:y0721. ypm:YP_0619.
Phylogenomic databases
HOGENOM	HOG000037637.
KO	K05774.
OMA	KVINVTA.
ProtClustDB	PRK10078.
Enzyme and pathway databases
BioCyc	YPES214092:GKDD-3418-MONOMER.
UniPathway	UPA00087; UER00175.
Family and domain databases
HAMAP	MF_00836. PhnN.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR027417. P-loop_NTPase. IPR012699. PhnN. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR02322. phosphon_PhnN. 1 hit.
PROSITE	PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHNN_YERPE

Accession

Primary (citable) accession number: Q7CKG8
Secondary accession number(s): Q74X43

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 21, 2011
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program