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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA), Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:YPO2567, y1620, YP_2378
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055551 – 717Phosphate acetyltransferaseAdd BLAST717

Proteomic databases

PaxDbiQ7CJ96
PRIDEiQ7CJ96

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

IntActiQ7CJ96, 2 interactors
STRINGi187410.y1620

Structurei

3D structure databases

ProteinModelPortaliQ7CJ96
SMRiQ7CJ96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 717Phosphate acetyltransferaseAdd BLAST328

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105C6K Bacteria
COG0280 LUCA
COG0857 LUCA
HOGENOMiHOG000053797
KOiK13788
OMAiTPLMFEY

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q7CJ96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIMLIPT GTSVGLTSVS LGVIRSMEQK GVSLSVFKPI AQPRAGNDAP
60 70 80 90 100
DQTTTIIRAN SSITAAEPLN MNYVETLLSS NQQDVLMEEI VARYHENTKD
110 120 130 140 150
AEVVLVEGLV PTRKHQFANA LNYEIAKTLN AEIVFVIALG NDSPDQLKER
160 170 180 190 200
IELARSSFGG SKNKNITGVI INKLNAPVDE QGRTRPDLSE IFDDSTKASV
210 220 230 240 250
ANIDPSQLFA NSPIPVLGCV PWSFELIATR AIDMAKHLNA RIINEGDIKT
260 270 280 290 300
RRVKSVTFCA RSIPHMLEHF RPGSLLVTSA DRPDVLVSAC LAAMNGVEIG
310 320 330 340 350
AILLTGGYAI DDRINNLCER AFQTGLPVFM VDTNTWQTSL SLQSFNLEVP
360 370 380 390 400
ADDHERVEKL QNYVASHISS EWIDSLTAAS ERPRRLSPPA FRYELTELAR
410 420 430 440 450
KAGKRIVLPE GDEPRTIKAA SICAERGIAT CVLLGNPEEI QRVATSQGVE
460 470 480 490 500
LGKGVEIIDP VAVREQYVPR LVELRKSKGM TEVVAREQLE DNVVLGTLML
510 520 530 540 550
EKGEVDGLVS GAVHTTANTI RPPLQLIKTA PGSSLVSSVF FMLLPDQVLV
560 570 580 590 600
YGDCAINPDP TAEQLSEIAI QSADSAAAFG IEPRVAMISY STGNSGAGSD
610 620 630 640 650
VEKVREATRL AQEKRPDLII DGPLQYDAAI MADVAKSKAP NSPVAGRATV
660 670 680 690 700
FIFPDLNTGN TTYKAVQRSA DLISIGPMLQ GMRKPVNDLS RGALVDDIVY
710
TVALTAIQSA QADSAAS
Length:717
Mass (Da):77,402
Last modified:July 5, 2004 - v1
Checksum:i4AB841751C30C2A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009952 Genomic DNA Translation: AAM85189.1
AE017042 Genomic DNA Translation: AAS62583.1
AL590842 Genomic DNA Translation: CAL21192.1
PIRiAE0313
RefSeqiWP_002225867.1, NZ_PDBR01000026.1
YP_002347528.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85189; AAM85189; y1620
AAS62583; AAS62583; YP_2378
GeneIDi1175398
KEGGiype:YPO2567
ypj:CH55_46
ypk:y1620
ypl:CH46_2550
ypm:YP_2378
ypv:BZ15_972
ypw:CH59_99
PATRICifig|214092.21.peg.2990

Similar proteinsi

Entry informationi

Entry nameiPTA_YERPE
AccessioniPrimary (citable) accession number: Q7CJ96
Secondary accession number(s): Q74T19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health