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Q7CJ96 (PTA_YERPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphate acetyltransferase

EC=2.3.1.8
Alternative name(s):
Phosphotransacetylase
Gene names
Name:pta
Ordered Locus Names:YPO2567, y1620, YP_2378
OrganismYersinia pestis [Reference proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length717 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in acetate metabolism By similarity.

Catalytic activity

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm Potential.

Domain

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site By similarity.

Sequence similarities

In the N-terminal section; belongs to the CobB/CobQ family.

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacetyl-CoA biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphate acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 717717Phosphate acetyltransferase
PRO_0000405555

Regions

Region390 – 717328Phosphate acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
Q7CJ96 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4AB841751C30C2A3

FASTA71777,402
        10         20         30         40         50         60 
MSRTIMLIPT GTSVGLTSVS LGVIRSMEQK GVSLSVFKPI AQPRAGNDAP DQTTTIIRAN 

        70         80         90        100        110        120 
SSITAAEPLN MNYVETLLSS NQQDVLMEEI VARYHENTKD AEVVLVEGLV PTRKHQFANA 

       130        140        150        160        170        180 
LNYEIAKTLN AEIVFVIALG NDSPDQLKER IELARSSFGG SKNKNITGVI INKLNAPVDE 

       190        200        210        220        230        240 
QGRTRPDLSE IFDDSTKASV ANIDPSQLFA NSPIPVLGCV PWSFELIATR AIDMAKHLNA 

       250        260        270        280        290        300 
RIINEGDIKT RRVKSVTFCA RSIPHMLEHF RPGSLLVTSA DRPDVLVSAC LAAMNGVEIG 

       310        320        330        340        350        360 
AILLTGGYAI DDRINNLCER AFQTGLPVFM VDTNTWQTSL SLQSFNLEVP ADDHERVEKL 

       370        380        390        400        410        420 
QNYVASHISS EWIDSLTAAS ERPRRLSPPA FRYELTELAR KAGKRIVLPE GDEPRTIKAA 

       430        440        450        460        470        480 
SICAERGIAT CVLLGNPEEI QRVATSQGVE LGKGVEIIDP VAVREQYVPR LVELRKSKGM 

       490        500        510        520        530        540 
TEVVAREQLE DNVVLGTLML EKGEVDGLVS GAVHTTANTI RPPLQLIKTA PGSSLVSSVF 

       550        560        570        580        590        600 
FMLLPDQVLV YGDCAINPDP TAEQLSEIAI QSADSAAAFG IEPRVAMISY STGNSGAGSD 

       610        620        630        640        650        660 
VEKVREATRL AQEKRPDLII DGPLQYDAAI MADVAKSKAP NSPVAGRATV FIFPDLNTGN 

       670        680        690        700        710 
TTYKAVQRSA DLISIGPMLQ GMRKPVNDLS RGALVDDIVY TVALTAIQSA QADSAAS 

« Hide

References

[1]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM10+ / Biovar Mediaevalis.
[2]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009952 Genomic DNA. Translation: AAM85189.1.
AE017042 Genomic DNA. Translation: AAS62583.1.
AL590842 Genomic DNA. Translation: CAL21192.1.
PIRAE0313.
RefSeqNP_668938.1. NC_004088.1.
NP_993706.1. NC_005810.1.
YP_002347528.1. NC_003143.1.

3D structure databases

ProteinModelPortalQ7CJ96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ7CJ96. 2 interactions.
STRING214092.YPO2567.

Proteomic databases

PRIDEQ7CJ96.

Protocols and materials databases

DNASU1146567.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM85189; AAM85189; y1620.
AAS62583; AAS62583; YP_2378.
GeneID1146567.
1175398.
2766685.
KEGGype:YPO2567.
ypk:y1620.
ypm:YP_2378.

Phylogenomic databases

eggNOGCOG0280.
HOGENOMHOG000053797.
KOK13788.
OMAKPIAQPH.
OrthoDBEOG6BKJ5W.
ProtClustDBPRK05632.

Enzyme and pathway databases

BioCycYPES214092:GKDD-2535-MONOMER.
UniPathwayUPA00340; UER00459.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00651. pta. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTA_YERPE
AccessionPrimary (citable) accession number: Q7CJ96
Secondary accession number(s): Q74T19
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways