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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciYPES214092:GKDD-2535-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:YPO2567, y1620, YP_2378
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Phosphate acetyltransferasePRO_0000405555Add
BLAST

Proteomic databases

PRIDEiQ7CJ96.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

IntActiQ7CJ96. 2 interactions.
STRINGi214092.YPO2567.

Structurei

3D structure databases

ProteinModelPortaliQ7CJ96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni390 – 717328Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CJ96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRTIMLIPT GTSVGLTSVS LGVIRSMEQK GVSLSVFKPI AQPRAGNDAP
60 70 80 90 100
DQTTTIIRAN SSITAAEPLN MNYVETLLSS NQQDVLMEEI VARYHENTKD
110 120 130 140 150
AEVVLVEGLV PTRKHQFANA LNYEIAKTLN AEIVFVIALG NDSPDQLKER
160 170 180 190 200
IELARSSFGG SKNKNITGVI INKLNAPVDE QGRTRPDLSE IFDDSTKASV
210 220 230 240 250
ANIDPSQLFA NSPIPVLGCV PWSFELIATR AIDMAKHLNA RIINEGDIKT
260 270 280 290 300
RRVKSVTFCA RSIPHMLEHF RPGSLLVTSA DRPDVLVSAC LAAMNGVEIG
310 320 330 340 350
AILLTGGYAI DDRINNLCER AFQTGLPVFM VDTNTWQTSL SLQSFNLEVP
360 370 380 390 400
ADDHERVEKL QNYVASHISS EWIDSLTAAS ERPRRLSPPA FRYELTELAR
410 420 430 440 450
KAGKRIVLPE GDEPRTIKAA SICAERGIAT CVLLGNPEEI QRVATSQGVE
460 470 480 490 500
LGKGVEIIDP VAVREQYVPR LVELRKSKGM TEVVAREQLE DNVVLGTLML
510 520 530 540 550
EKGEVDGLVS GAVHTTANTI RPPLQLIKTA PGSSLVSSVF FMLLPDQVLV
560 570 580 590 600
YGDCAINPDP TAEQLSEIAI QSADSAAAFG IEPRVAMISY STGNSGAGSD
610 620 630 640 650
VEKVREATRL AQEKRPDLII DGPLQYDAAI MADVAKSKAP NSPVAGRATV
660 670 680 690 700
FIFPDLNTGN TTYKAVQRSA DLISIGPMLQ GMRKPVNDLS RGALVDDIVY
710
TVALTAIQSA QADSAAS
Length:717
Mass (Da):77,402
Last modified:July 5, 2004 - v1
Checksum:i4AB841751C30C2A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009952 Genomic DNA. Translation: AAM85189.1.
AE017042 Genomic DNA. Translation: AAS62583.1.
AL590842 Genomic DNA. Translation: CAL21192.1.
PIRiAE0313.
RefSeqiNP_668938.1. NC_004088.1.
NP_993706.1. NC_005810.1.
YP_002347528.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM85189; AAM85189; y1620.
AAS62583; AAS62583; YP_2378.
GeneIDi1146567.
1175398.
2766685.
KEGGiype:YPO2567.
ypk:y1620.
ypm:YP_2378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009952 Genomic DNA. Translation: AAM85189.1.
AE017042 Genomic DNA. Translation: AAS62583.1.
AL590842 Genomic DNA. Translation: CAL21192.1.
PIRiAE0313.
RefSeqiNP_668938.1. NC_004088.1.
NP_993706.1. NC_005810.1.
YP_002347528.1. NC_003143.1.

3D structure databases

ProteinModelPortaliQ7CJ96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7CJ96. 2 interactions.
STRINGi214092.YPO2567.

Proteomic databases

PRIDEiQ7CJ96.

Protocols and materials databases

DNASUi1146567.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM85189; AAM85189; y1620.
AAS62583; AAS62583; YP_2378.
GeneIDi1146567.
1175398.
2766685.
KEGGiype:YPO2567.
ypk:y1620.
ypm:YP_2378.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciYPES214092:GKDD-2535-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPTA_YERPE
AccessioniPrimary (citable) accession number: Q7CJ96
Secondary accession number(s): Q74T19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.