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Protein

Beta-galactosidase

Gene

lacZ

Organism
Yersinia pestis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation
  • Na+UniRule annotationNote: Binds 1 sodium ion per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110SubstrateUniRule annotation1
Metal bindingi209SodiumUniRule annotation1
Binding sitei209SubstrateUniRule annotation1
Sitei373Transition state stabilizerUniRule annotation1
Sitei407Transition state stabilizerUniRule annotation1
Metal bindingi432Magnesium 1UniRule annotation1
Metal bindingi434Magnesium 1UniRule annotation1
Active sitei477Proton donorUniRule annotation1
Metal bindingi477Magnesium 1UniRule annotation1
Binding sitei477SubstrateUniRule annotation1
Active sitei553NucleophileUniRule annotation1
Metal bindingi613Magnesium 2UniRule annotation1
Metal bindingi617Sodium; via carbonyl oxygenUniRule annotation1
Metal bindingi620SodiumUniRule annotation1
Binding sitei620SubstrateUniRule annotation1
Binding sitei1035SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMagnesium, Metal-binding, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZUniRule annotation
Ordered Locus Names:YPO1654, y1817, YP_1785
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Chromosome
  • UP000001019 Componenti: Chromosome
  • UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670151 – 1060Beta-galactosidaseAdd BLAST1060

Proteomic databases

PaxDbiQ7CIZ3
PRIDEiQ7CIZ3

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

IntActiQ7CIZ3, 9 interactors
STRINGi187410.y1817

Structurei

3D structure databases

ProteinModelPortaliQ7CIZ3
SMRiQ7CIZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni553 – 556Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA
HOGENOMiHOG000252443
KOiK01190
OMAiPSNWQLQ

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.70.98.10, 1 hit
HAMAPiMF_01687 Beta_gal, 1 hit
InterProiView protein in InterPro
IPR004199 B-gal_small/dom_5
IPR036156 Beta-gal/glucu_dom_sf
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR023933 Glyco_hydro_2_beta_Galsidase
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR032312 LacZ_4
PANTHERiPTHR10066:SF76 PTHR10066:SF76, 1 hit
PfamiView protein in Pfam
PF02929 Bgal_small_N, 1 hit
PF16353 DUF4981, 1 hit
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SMARTiView protein in SMART
SM01038 Bgal_small_N, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7CIZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQEKVPLQ VQLSLPQILS RRDWENPQIT QYHRLEAHPP FHSWRDVESA
60 70 80 90 100
QKDRPSPQQQ TLNGLWSFSY FTQPEAVPEH WVRCDLAEAK PLPVPANWQL
110 120 130 140 150
HGYDAPIYTN IQYPIPVNPP RVPDLNPTGC YSRDFTLEPS WLASGKTRII
160 170 180 190 200
FDGVSSAFYL WCNGQWVGYS QDSRLPAEFD LTPYLQAGSN RIAVLVLRWS
210 220 230 240 250
DGSYLEDQDM WRMSGIFRDV KLLHKPEIHL RDIHIMTHLS PEFTSANLEV
260 270 280 290 300
MAAVNIPSLQ LNDPQVTGSY QLRVQLWLAD KLVASLQQPL GTQAIDERGP
310 320 330 340 350
YTDRTQLVLR IDQPLLWSAE QPTLYRAVVS LLNHQQELIE AEAYDVGFRQ
360 370 380 390 400
VAIHQGLLKI NGKAVLIRGV NRHEHHPQTG QAIDEESLLQ DILLMKQHNF
410 420 430 440 450
NAVRCSHYPN HPLWYRLCDR YGLYVVDEAN IETHGMQPMS RLSDDPSWFS
460 470 480 490 500
AFSERVTRMV QRDRNHPCII IWSLGNESGH GATHDALYRW IKTNDPTRPV
510 520 530 540 550
QYEGGGANTL ATDILCPMYA RVDEDQPFPA VPKWSIKKWI GLPNESRPLI
560 570 580 590 600
LCEYAHAMGN SFGGFARYWQ AFRQYPRLQG GFIWDWVDQS LTHHNDHGQP
610 620 630 640 650
YWAYGGDFGD TPNDRQFCMN GLVFPDRSPH PSLYEAQCAQ QFFQFSLLST
660 670 680 690 700
TPLVINITSE YLFRESDNEQ LYWRIMLEGE SVLEGSQPLN LSPESSQCYR
710 720 730 740 750
LAEKLPTLNK PGQLWLNVEI RQPKETPWSP AQHRSAWHQW RLPQPLFSPS
760 770 780 790 800
SDLTNATAHY APQLQHNLQL QHDLQLQQDE QHIKVTYQQQ CWQFSRQTGR
810 820 830 840 850
LAQWWVADKP MLLRPLQDQF VRAPLDNDIG ISEATHIDPN AWVERWKKAG
860 870 880 890 900
MYQLQQRCLS LHVDHLSHSV QISAEYGYEF EQEPLLHSHW VYRFDRHGRM
910 920 930 940 950
TIDVNVRIAT SLPAPARIGM CCQLADISPT VEWLGLGPHE NYPDRQLAAQ
960 970 980 990 1000
YGHWSLPLEQ MHTAYIFPSE NGLRCNTHTL NYGRWTLTGD FHFGISRYST
1010 1020 1030 1040 1050
QQLMVTSHQH LLEPEEGTWL NIDGFHMGVG GDDSWSPSVH IDDILTRETY
1060
QYQICWQYKV
Length:1,060
Mass (Da):122,625
Last modified:July 5, 2004 - v1
Checksum:i1142D7FC68E46697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009952 Genomic DNA Translation: AAM85385.1
AE017042 Genomic DNA Translation: AAS62012.1
AL590842 Genomic DNA Translation: CAL20299.1
PIRiAI0201
RefSeqiWP_002214048.1, NZ_PDBR01000025.1
YP_002346664.1, NC_003143.1

Genome annotation databases

EnsemblBacteriaiAAM85385; AAM85385; y1817
AAS62012; AAS62012; YP_1785
GeneIDi1174493
KEGGiype:YPO1654
ypk:y1817
ypl:CH46_3471
ypm:YP_1785
ypv:BZ15_1897
ypw:CH59_183
PATRICifig|214092.21.peg.2000

Similar proteinsi

Entry informationi

Entry nameiBGAL_YERPE
AccessioniPrimary (citable) accession number: Q7CIZ3
Secondary accession number(s): Q74UE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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