Reviewed,
UniProtKB/Swiss-Prot Q7CGS4 (E4PD_YERPE)
Last modified
November 25, 2008.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: D-erythrose-4-phosphate dehydrogenase Short name=E4PDH EC=1.2.1.72 | ||||
| Gene names |
| ||||
| Organism | Yersinia pestis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 632 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia |
Protein attributes
| Sequence length | 338 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate By similarity. |
| Catalytic activity | D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Pyridoxine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate biosynthetic processInferred from electronic annotation. Source: HAMAP pyridoxine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: HAMAP |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro erythrose-4-phosphate dehydrogenase activityInferred from electronic annotation. Source: HAMAP glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 338 | 338 | D-erythrose-4-phosphate dehydrogenase | PRO_0000293180 | |||||
Regions | |||||||||
| Nucleotide binding | 12 – 13 | 2 | NAD By similarity | ||||||
| Region | 154 – 156 | 3 | Substrate binding Potential | ||||||
| Region | 213 – 214 | 2 | Substrate binding Potential | ||||||
Sites | |||||||||
| Active site | 155 | 1 | Nucleophile By similarity | ||||||
| Binding site | 200 | 1 | Substrate Potential | ||||||
| Binding site | 236 | 1 | Substrate Potential | ||||||
| Binding site | 318 | 1 | NAD By similarity | ||||||
| Site | 182 | 1 | Activates thiol group during catalysis By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AL590842 Genomic DNA. Translation: CAL19589.1. AE009952 Genomic DNA. Translation: AAM86859.1. AE017042 Genomic DNA. Translation: AAS63672.1. | |
| PIR | AC0113. |
| RefSeq | NP_670608.1. NP_994795.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HDG based on UniProtKB P17721. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1148256. 2763824. |
| GenomeReviews | Gene locus y3309 in contig AE009952_GR. Gene locus YP_3518 in contig AE017042_GR. Gene locus YPO0922 in contig AL590842_GR. |
| KEGG | ype:YPO0922. ypk:y3309. ypm:YP_3518. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q7CGS4. |
Enzyme and pathway databases | |
| BioCyc | YPES187410:Y3309-MON. YPES229193:YP3518-MON. |
Family and domain databases | |
| HAMAP | MF_01640. [Tree] |
| InterPro | IPR006422. E4P_DHase_bac. IPR000173. GlycerAld_3-P_DHase. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR10836. GAP_DH. 1 hit. |
| Pfam | PF02800. Gp_dh_C. 1 hit. PF00044. Gp_dh_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000149. GAP_DH. 1 hit. |
| PRINTS | PR00078. G3PDHDRGNASE. |
| TIGRFAMs | TIGR01532. E4PD_g-proteo. 1 hit. |
| PROSITE | PS00071. GAPDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | E4PD_YERPE | ||||||||
| Accession | Primary (citable) accession number: Q7CGS4 Secondary accession number(s): Q74QG3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


