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Reviewed, UniProtKB/Swiss-Prot Q7CGS4 (E4PD_YERPE)

Last modified February 9, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    D-erythrose-4-phosphate dehydrogenase
      Short name=E4PDH
    EC=1.2.1.72
Gene names
Name: epd
Ordered Locus Names: YPO0922, y3309, YP_3518
OrganismYersinia pestis [Complete proteome] [HAMAP]
Taxonomic identifier632 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate By similarity. HAMAP MF_01640

Catalytic activity

D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH. HAMAP MF_01640

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5. HAMAP MF_01640

Subunit structure

Homotetramer By similarity. HAMAP MF_01640

Subcellular location

Cytoplasm By similarity HAMAP MF_01640.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338D-erythrose-4-phosphate dehydrogenase HAMAP MF_01640
PRO_0000293180

Regions

Nucleotide binding12 – 132NAD By similarity
Region154 – 1563Substrate binding Potential
Region213 – 2142Substrate binding Potential

Sites

Active site1551Nucleophile By similarity
Binding site2001Substrate Potential
Binding site2361Substrate Potential
Binding site3181NAD By similarity
Site1821Activates thiol group during catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7CGS4-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5E0A54DCAD224E06

FASTA33837,015
        10         20         30         40         50         60 
MAIRIAINGF GRIGRSVLRA LYESGRRAEI SVVAINELAS AEGMAHLLKY DSSHGRFAWD 

        70         80         90        100        110        120 
VRQECDSLYV GDDIIRLIHQ SEIEQLPWSE LGIDVVLDCS GVYGSREDGE AHVASGAKKV 

       130        140        150        160        170        180 
LFAHPGGHDL DATVVYGVNH QDLRAEHRIV SNASCTTNCI IPIIQLLDIA YGIESGTVTT 

       190        200        210        220        230        240 
IHSSMNDQPV IDAYHQDLRR TRAASQSIIP VDTKLAAGIT RIFPKFCDRF EAISVRVPTI 

       250        260        270        280        290        300 
NVTAIDLSVS VTHPVGVAEV NQLLQKAARG AFRGIVDYTE LPLVSMDFNH DPHSAIVDGT 

       310        320        330 
QTRVSGQHLI KTLVWCDNEW GFANRMLDTT LAMAKSGF 

« Hide

References

[1]"Genome sequence of Yersinia pestis, the causative agent of plague."
Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G., Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L., Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M., Chillingworth T., Cronin A., Davies R.M. expand/collapse author list , Davis P., Dougan G., Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:523-527(2001) [PubMed: 11586360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CO-92 / Biovar Orientalis.
[2]"Genome sequence of Yersinia pestis KIM."
Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P., Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A., Nilles M.L. expand/collapse author list , Matson J.S., Blattner F.R., Perry R.D.
J. Bacteriol. 184:4601-4611(2002) [PubMed: 12142430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KIM5 / Biovar Mediaevalis.
[3]"Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R. expand/collapse author list , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
DNA Res. 11:179-197(2004) [PubMed: 15368893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 91001 / Biovar Mediaevalis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590842 Genomic DNA. Translation: CAL19589.1.
AE009952 Genomic DNA. Translation: AAM86859.1.
AE017042 Genomic DNA. Translation: AAS63672.1.
PIRAC0113.
RefSeqNP_670608.1.
NP_994795.1.
YP_002345970.1.

3D structure databases

SMRQ7CGS4. Positions 2-336.
ModBaseSearch...

Genome annotation databases

GeneID1148256.
1173759.
2763824.
GenomeReviewsGene locus y3309 in contig AE009952_GR.
Gene locus YP_3518 in contig AE017042_GR.
Gene locus YPO0922 in contig AL590842_GR.
KEGGype:YPO0922.
ypk:y3309.
ypm:YP_3518.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG571736.
OMAIQAKAVR.

Enzyme and pathway databases

BioCycYPES187410:Y3309-MONOMER.
YPES229193:YP3518-MONOMER.
BRENDA1.2.1.72. 142588.

Family and domain databases

HAMAPMF_01640. E4P_dehydrog.
[Tree]
InterProIPR006422. E4P_DH_bac.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020832. GlycerAld_3-P_DH_cat_sub.
IPR020831. GlycerAld_3-P_DH_family.
IPR020828. GlycerAld_3-P_DH_NAD(P)_bd.
IPR000173. GlycerAld_3-P_DH_subfam.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10836. GAP_DH. 1 hit.
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
PRINTSPR00078. G3PDHDRGNASE.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01532. E4PD_g-proteo. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE4PD_YERPE
AccessionPrimary (citable) accession number: Q7CGS4
Secondary accession number(s): Q74QG3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents