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Q7CEG3

- VIRB8_BRUSU

UniProt

Q7CEG3 - VIRB8_BRUSU

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Protein

Type IV secretion system protein virB8

Gene
virB8, BRA0062, BS1330_II0062
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The VirB system could be required for the establishment of the replication niche in the host.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. protein secretion by the type IV secretion system Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein virB8
Gene namesi
Name:virB8
Ordered Locus Names:BRA0062, BS1330_II0062
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Type IV secretion system protein virB8PRO_0000291392Add
BLAST

Expressioni

Inductioni

Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-6407073,EBI-6407073

Protein-protein interaction databases

IntActiQ7CEG3. 1 interaction.
MINTiMINT-8194075.
STRINGi204722.BRA0062.

Structurei

Secondary structure

1
239
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi98 – 11518
Helixi119 – 1213
Helixi122 – 13211
Helixi135 – 1428
Helixi143 – 1453
Beta strandi146 – 1494
Helixi151 – 1555
Beta strandi158 – 17013
Beta strandi172 – 18918
Beta strandi194 – 20613
Helixi209 – 2113
Helixi214 – 2174
Beta strandi224 – 23310

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BHMX-ray2.40A/B/C/D/E77-239[»]
4AKYX-ray2.60A/B/C/D/E97-234[»]
4AKZX-ray2.25A/B/C/D/E97-234[»]
ProteinModelPortaliQ7CEG3.
SMRiQ7CEG3. Positions 97-234.

Miscellaneous databases

EvolutionaryTraceiQ7CEG3.

Family & Domainsi

Sequence similaritiesi

Belongs to the virB8 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3736.
HOGENOMiHOG000119601.
KOiK03203.
OMAiEMSDESV.
OrthoDBiEOG6Z9B0F.

Family and domain databases

InterProiIPR007430. VirB8.
IPR026264. VirB8/PtlE.
[Graphical view]
PfamiPF04335. VirB8. 1 hit.
[Graphical view]
PIRSFiPIRSF003299. VirB8_PtlE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CEG3-1 [UniParc]FASTAAdd to Basket

« Hide

MFGRKQSPQK SVKNGQGNAP SVYDEALNWE AAHVRLVEKS ERRAWKIAGA    50
FGTITVLLGI GIAGMLPLKQ HVPYLVRVNA QTGAPDILTS LDEKSVSYDT 100
VMDKYWLSQY VIARETYDWY TLQKDYETVG MLSSPSEGQS YASQFQGDKA 150
LDKQYGSNVR TSVTIVSIVP NGKGIGTVRF AKTTKRTNET GDGETTHWIA 200
TIGYQYVNPS LMSESARLTN PLGFNVTSYR VDPEMGVVQ 239
Length:239
Mass (Da):26,446
Last modified:July 5, 2004 - v1
Checksum:i68F44CBCF7018023
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141604 Genomic DNA. Translation: AAD56618.1.
AE014292 Genomic DNA. Translation: AAN33274.1.
CP002998 Genomic DNA. Translation: AEM19554.1.
RefSeqiNP_699269.1. NC_004311.2.
YP_005613780.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33274; AAN33274; BRA0062.
AEM19554; AEM19554; BS1330_II0062.
GeneIDi1164499.
12139496.
KEGGibms:BRA0062.
bsi:BS1330_II0062.
PATRICi17792927. VBIBruSui107850_2282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141604 Genomic DNA. Translation: AAD56618.1 .
AE014292 Genomic DNA. Translation: AAN33274.1 .
CP002998 Genomic DNA. Translation: AEM19554.1 .
RefSeqi NP_699269.1. NC_004311.2.
YP_005613780.1. NC_017250.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BHM X-ray 2.40 A/B/C/D/E 77-239 [» ]
4AKY X-ray 2.60 A/B/C/D/E 97-234 [» ]
4AKZ X-ray 2.25 A/B/C/D/E 97-234 [» ]
ProteinModelPortali Q7CEG3.
SMRi Q7CEG3. Positions 97-234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7CEG3. 1 interaction.
MINTi MINT-8194075.
STRINGi 204722.BRA0062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN33274 ; AAN33274 ; BRA0062 .
AEM19554 ; AEM19554 ; BS1330_II0062 .
GeneIDi 1164499.
12139496.
KEGGi bms:BRA0062.
bsi:BS1330_II0062.
PATRICi 17792927. VBIBruSui107850_2282.

Phylogenomic databases

eggNOGi COG3736.
HOGENOMi HOG000119601.
KOi K03203.
OMAi EMSDESV.
OrthoDBi EOG6Z9B0F.

Miscellaneous databases

EvolutionaryTracei Q7CEG3.
PROi Q7CEG3.

Family and domain databases

InterProi IPR007430. VirB8.
IPR026264. VirB8/PtlE.
[Graphical view ]
Pfami PF04335. VirB8. 1 hit.
[Graphical view ]
PIRSFi PIRSF003299. VirB8_PtlE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis."
    O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.
    Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS.
    Strain: 1330.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  5. "Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori."
    Terradot L., Bayliss R., Oomen C., Leonard G.A., Baron C., Waksman G.
    Proc. Natl. Acad. Sci. U.S.A. 102:4596-4601(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 77-239.

Entry informationi

Entry nameiVIRB8_BRUSU
AccessioniPrimary (citable) accession number: Q7CEG3
Secondary accession number(s): G0KER0, Q7BQL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription of the operon is maximal in early exponential phase.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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