Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Type IV secretion system protein virB8

Gene

virB8

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The VirB system could be required for the establishment of the replication niche in the host.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein virB8
Gene namesi
Name:virB8
Ordered Locus Names:BRA0062, BS1330_II0062
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002913921 – 239Type IV secretion system protein virB8Add BLAST239

Expressioni

Inductioni

Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-6407073,EBI-6407073
virB10Q9RPX54EBI-6407073,EBI-7022388

Protein-protein interaction databases

DIPiDIP-61163N.
IntActiQ7CEG3. 1 interactor.
MINTiMINT-8194075.

Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi98 – 115Combined sources18
Helixi119 – 121Combined sources3
Helixi122 – 132Combined sources11
Helixi135 – 142Combined sources8
Helixi143 – 145Combined sources3
Beta strandi146 – 149Combined sources4
Helixi151 – 155Combined sources5
Beta strandi158 – 170Combined sources13
Beta strandi172 – 189Combined sources18
Beta strandi194 – 206Combined sources13
Helixi209 – 211Combined sources3
Helixi214 – 217Combined sources4
Beta strandi224 – 233Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BHMX-ray2.40A/B/C/D/E77-239[»]
4AKYX-ray2.60A/B/C/D/E97-234[»]
4AKZX-ray2.25A/B/C/D/E97-234[»]
ProteinModelPortaliQ7CEG3.
SMRiQ7CEG3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7CEG3.

Family & Domainsi

Sequence similaritiesi

Belongs to the virB8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000119601.
KOiK03203.
OMAiQDKHWVE.

Family and domain databases

InterProiIPR032710. NTF2-like_dom.
IPR007430. VirB8.
IPR026264. VirB8/PtlE.
[Graphical view]
PfamiPF04335. VirB8. 1 hit.
[Graphical view]
PIRSFiPIRSF003299. VirB8_PtlE. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7CEG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGRKQSPQK SVKNGQGNAP SVYDEALNWE AAHVRLVEKS ERRAWKIAGA
60 70 80 90 100
FGTITVLLGI GIAGMLPLKQ HVPYLVRVNA QTGAPDILTS LDEKSVSYDT
110 120 130 140 150
VMDKYWLSQY VIARETYDWY TLQKDYETVG MLSSPSEGQS YASQFQGDKA
160 170 180 190 200
LDKQYGSNVR TSVTIVSIVP NGKGIGTVRF AKTTKRTNET GDGETTHWIA
210 220 230
TIGYQYVNPS LMSESARLTN PLGFNVTSYR VDPEMGVVQ
Length:239
Mass (Da):26,446
Last modified:July 5, 2004 - v1
Checksum:i68F44CBCF7018023
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141604 Genomic DNA. Translation: AAD56618.1.
AE014292 Genomic DNA. Translation: AAN33274.1.
CP002998 Genomic DNA. Translation: AEM19554.1.
RefSeqiWP_002966517.1. NZ_KN046805.1.

Genome annotation databases

EnsemblBacteriaiAAN33274; AAN33274; BRA0062.
AEM19554; AEM19554; BS1330_II0062.
GeneIDi3827898.
KEGGibms:BRA0062.
bsi:BS1330_II0062.
PATRICi17792927. VBIBruSui107850_2282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141604 Genomic DNA. Translation: AAD56618.1.
AE014292 Genomic DNA. Translation: AAN33274.1.
CP002998 Genomic DNA. Translation: AEM19554.1.
RefSeqiWP_002966517.1. NZ_KN046805.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BHMX-ray2.40A/B/C/D/E77-239[»]
4AKYX-ray2.60A/B/C/D/E97-234[»]
4AKZX-ray2.25A/B/C/D/E97-234[»]
ProteinModelPortaliQ7CEG3.
SMRiQ7CEG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61163N.
IntActiQ7CEG3. 1 interactor.
MINTiMINT-8194075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33274; AAN33274; BRA0062.
AEM19554; AEM19554; BS1330_II0062.
GeneIDi3827898.
KEGGibms:BRA0062.
bsi:BS1330_II0062.
PATRICi17792927. VBIBruSui107850_2282.

Phylogenomic databases

HOGENOMiHOG000119601.
KOiK03203.
OMAiQDKHWVE.

Miscellaneous databases

EvolutionaryTraceiQ7CEG3.
PROiQ7CEG3.

Family and domain databases

InterProiIPR032710. NTF2-like_dom.
IPR007430. VirB8.
IPR026264. VirB8/PtlE.
[Graphical view]
PfamiPF04335. VirB8. 1 hit.
[Graphical view]
PIRSFiPIRSF003299. VirB8_PtlE. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVIRB8_BRUSU
AccessioniPrimary (citable) accession number: Q7CEG3
Secondary accession number(s): G0KER0, Q7BQL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription of the operon is maximal in early exponential phase.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.