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Q7C637 (XYLA_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylose isomerase

EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:STY4137, t3858
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylopyranose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_00455

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00455

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Xylose isomerase HAMAP-Rule MF_00455
PRO_0000195792

Sites

Active site1011 By similarity
Active site1041 By similarity
Metal binding2321Magnesium 1 By similarity
Metal binding2681Magnesium 1 By similarity
Metal binding2681Magnesium 2 By similarity
Metal binding2711Magnesium 2 By similarity
Metal binding2961Magnesium 1 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3391Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7C637 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B04CF1BAE17A8EAB

FASTA44049,640
        10         20         30         40         50         60 
MQAYFDQLDR VRYEGPQSTN PLAFRHYNPD ELVLGKRMED HLRFAACYWH TFCWNGADMF 

        70         80         90        100        110        120 
GVGAFNRPWQ QPGEALELAK RKADVAFEFF HKLNVPFYCF HDVDVSPKGA SLKEYKNNFA 

       130        140        150        160        170        180 
QMVDVLAAKQ EQSGVKLLWG TANCFTNPRY GAGAATNPDP EVFSCAATQV VTAMNATHKL 

       190        200        210        220        230        240 
GGENYVLWGG REGYETLLNT DLRQEREQIG RFMQMVVEHK HKMGFQGTLL IEPKPQEPTK 

       250        260        270        280        290        300 
HQYDYDVATV YGFLKQFGLE KEIKVNIEAN HATLAGHSFH HEIATAIALG IFGSVDANRG 

       310        320        330        340        350        360 
DAQLGWDTDQ FPISVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY DLFYGHIGAM 

       370        380        390        400        410        420 
DTMALSLKIA ARMVEDGELD KRVAKRYAGW NGELGQQILK GQLSLGELAQ YAEQHHLAPV 

       430        440 
HQSGHQELLE NLVNRYLFDK 

« Hide

References

[1]"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18."
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. expand/collapse author list , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:848-852(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT18.
[2]"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700931 / Ty2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513382 Genomic DNA. Translation: CAD07967.1.
AE014613 Genomic DNA. Translation: AAO71338.1.
RefSeqNP_458266.1. NC_003198.1.
NP_807478.1. NC_004631.1.

3D structure databases

ProteinModelPortalQ7C637.
SMRQ7C637. Positions 3-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220341.STY4137.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO71338; AAO71338; t3858.
CAD07967; CAD07967; CAD07967.
GeneID1250366.
KEGGsty:STY4137.
PATRIC18546482. VBISalEnt120419_4226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2115.
HOGENOMHOG000252293.
KOK01805.
OMALFHAHIG.
OrthoDBEOG62NX4R.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_SALTI
AccessionPrimary (citable) accession number: Q7C637
Secondary accession number(s): Q8Z2B8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families