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Q7C637

- XYLA_SALTI

UniProt

Q7C637 - XYLA_SALTI

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Protein
Xylose isomerase
Gene
xylA, STY4137, t3858
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011 By similarity
Active sitei104 – 1041 By similarity
Metal bindingi232 – 2321Magnesium 1 By similarity
Metal bindingi268 – 2681Magnesium 1 By similarity
Metal bindingi268 – 2681Magnesium 2 By similarity
Metal bindingi271 – 2711Magnesium 2 By similarity
Metal bindingi296 – 2961Magnesium 1 By similarity
Metal bindingi307 – 3071Magnesium 2 By similarity
Metal bindingi309 – 3091Magnesium 2 By similarity
Metal bindingi339 – 3391Magnesium 1 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:STY4137, t3858
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Xylose isomeraseUniRule annotation
PRO_0000195792Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY4137.

Structurei

3D structure databases

ProteinModelPortaliQ7C637.
SMRiQ7C637. Positions 3-439.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiLFHAHIG.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7C637-1 [UniParc]FASTAAdd to Basket

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MQAYFDQLDR VRYEGPQSTN PLAFRHYNPD ELVLGKRMED HLRFAACYWH    50
TFCWNGADMF GVGAFNRPWQ QPGEALELAK RKADVAFEFF HKLNVPFYCF 100
HDVDVSPKGA SLKEYKNNFA QMVDVLAAKQ EQSGVKLLWG TANCFTNPRY 150
GAGAATNPDP EVFSCAATQV VTAMNATHKL GGENYVLWGG REGYETLLNT 200
DLRQEREQIG RFMQMVVEHK HKMGFQGTLL IEPKPQEPTK HQYDYDVATV 250
YGFLKQFGLE KEIKVNIEAN HATLAGHSFH HEIATAIALG IFGSVDANRG 300
DAQLGWDTDQ FPISVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY 350
DLFYGHIGAM DTMALSLKIA ARMVEDGELD KRVAKRYAGW NGELGQQILK 400
GQLSLGELAQ YAEQHHLAPV HQSGHQELLE NLVNRYLFDK 440
Length:440
Mass (Da):49,640
Last modified:July 5, 2004 - v1
Checksum:iB04CF1BAE17A8EAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD07967.1.
AE014613 Genomic DNA. Translation: AAO71338.1.
RefSeqiNP_458266.1. NC_003198.1.
NP_807478.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO71338; AAO71338; t3858.
CAD07967; CAD07967; CAD07967.
GeneIDi1250366.
KEGGisty:STY4137.
PATRICi18546482. VBISalEnt120419_4226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD07967.1 .
AE014613 Genomic DNA. Translation: AAO71338.1 .
RefSeqi NP_458266.1. NC_003198.1.
NP_807478.1. NC_004631.1.

3D structure databases

ProteinModelPortali Q7C637.
SMRi Q7C637. Positions 3-439.
ModBasei Search...

Protein-protein interaction databases

STRINGi 220341.STY4137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO71338 ; AAO71338 ; t3858 .
CAD07967 ; CAD07967 ; CAD07967 .
GeneIDi 1250366.
KEGGi sty:STY4137.
PATRICi 18546482. VBISalEnt120419_4226.

Phylogenomic databases

eggNOGi COG2115.
HOGENOMi HOG000252293.
KOi K01805.
OMAi LFHAHIG.
OrthoDBi EOG62NX4R.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiXYLA_SALTI
AccessioniPrimary (citable) accession number: Q7C637
Secondary accession number(s): Q8Z2B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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