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Q7C637

- XYLA_SALTI

UniProt

Q7C637 - XYLA_SALTI

Protein

Xylose isomerase

Gene

xylA

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011UniRule annotation
    Active sitei104 – 1041UniRule annotation
    Metal bindingi232 – 2321Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 2UniRule annotation
    Metal bindingi271 – 2711Magnesium 2UniRule annotation
    Metal bindingi296 – 2961Magnesium 1UniRule annotation
    Metal bindingi307 – 3071Magnesium 2UniRule annotation
    Metal bindingi309 – 3091Magnesium 2UniRule annotation
    Metal bindingi339 – 3391Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    Ordered Locus Names:STY4137, t3858
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Xylose isomerasePRO_0000195792Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi220341.STY4137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7C637.
    SMRiQ7C637. Positions 3-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2115.
    HOGENOMiHOG000252293.
    KOiK01805.
    OMAiLFHAHIG.
    OrthoDBiEOG62NX4R.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7C637-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAYFDQLDR VRYEGPQSTN PLAFRHYNPD ELVLGKRMED HLRFAACYWH    50
    TFCWNGADMF GVGAFNRPWQ QPGEALELAK RKADVAFEFF HKLNVPFYCF 100
    HDVDVSPKGA SLKEYKNNFA QMVDVLAAKQ EQSGVKLLWG TANCFTNPRY 150
    GAGAATNPDP EVFSCAATQV VTAMNATHKL GGENYVLWGG REGYETLLNT 200
    DLRQEREQIG RFMQMVVEHK HKMGFQGTLL IEPKPQEPTK HQYDYDVATV 250
    YGFLKQFGLE KEIKVNIEAN HATLAGHSFH HEIATAIALG IFGSVDANRG 300
    DAQLGWDTDQ FPISVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY 350
    DLFYGHIGAM DTMALSLKIA ARMVEDGELD KRVAKRYAGW NGELGQQILK 400
    GQLSLGELAQ YAEQHHLAPV HQSGHQELLE NLVNRYLFDK 440
    Length:440
    Mass (Da):49,640
    Last modified:July 5, 2004 - v1
    Checksum:iB04CF1BAE17A8EAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD07967.1.
    AE014613 Genomic DNA. Translation: AAO71338.1.
    RefSeqiNP_458266.1. NC_003198.1.
    NP_807478.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO71338; AAO71338; t3858.
    CAD07967; CAD07967; CAD07967.
    GeneIDi1250366.
    KEGGisty:STY4137.
    PATRICi18546482. VBISalEnt120419_4226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD07967.1 .
    AE014613 Genomic DNA. Translation: AAO71338.1 .
    RefSeqi NP_458266.1. NC_003198.1.
    NP_807478.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali Q7C637.
    SMRi Q7C637. Positions 3-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY4137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO71338 ; AAO71338 ; t3858 .
    CAD07967 ; CAD07967 ; CAD07967 .
    GeneIDi 1250366.
    KEGGi sty:STY4137.
    PATRICi 18546482. VBISalEnt120419_4226.

    Phylogenomic databases

    eggNOGi COG2115.
    HOGENOMi HOG000252293.
    KOi K01805.
    OMAi LFHAHIG.
    OrthoDBi EOG62NX4R.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiXYLA_SALTI
    AccessioniPrimary (citable) accession number: Q7C637
    Secondary accession number(s): Q8Z2B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3