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Protein

Beta-lactamase

Gene

blaZ

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaZImported
ORF Names:BN1321_410016Imported, BSZ10_12000Imported, BTN44_15565Imported, ERS072840_00155Imported, HMPREF3211_01027Imported, pSM39_16Imported, SAP013A_014Imported, SAP026A_004Imported, SAP036A_009Imported, SAP062B_008Imported, SAP064A_004Imported, SAP065B_012Imported, SAP066A_028Imported, SAP084B_009Imported, SAP086A_012Imported, SAP088A_025Imported, SAP090A_004Imported, SAP090A_049Imported, SAP090C_001Imported, SAP091A_023Imported, SAP092A_021Imported, SAP093C_016Imported, SAP094B_027Imported, SAP095A_002Imported, SAP101A_028Imported, VRA0047Imported
Encoded oniPlasmid 17.2 kb beta-lactamase plasmidImported
Plasmid SAP062BImported
Plasmid SAP064AImported
Plasmid SAP065BImported
Plasmid SAP066AImported
Plasmid SAP101AImported
Plasmid pBORa53Imported
Plasmid pCM05Imported
Plasmid pETBImported
Plasmid pI258Imported
Plasmid pLW043Imported
Plasmid pSK21Imported
Plasmid pSK23Imported
Plasmid pSK53Imported
Plasmid pSK57Imported
Plasmid pSK60Imported
Plasmid pSK74Imported
Plasmid pSK76Imported
Plasmid pSK79Imported
Plasmid pSK80Imported
Plasmid pSM39Imported
Plasmid pWBG756Imported
Plasmid unnamedImported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000186958 Componenti: Unassembled WGS sequence
  • UP000070177 Componenti: Unassembled WGS sequence
  • UP000039437 Componenti: Unassembled WGS sequence
  • UP000236484 Componenti: Chromosome
  • UP000069800 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501458766325 – 281Beta-lactamaseSequence analysisAdd BLAST257

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Q7BWD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLIFLIVI ALVLSACNSN SSHAKELNDL EKKYNAHIGV YALDTKSGKE
60 70 80 90 100
VKFNSDKRFA YASTSKAINS AILLEQVPYN KLNKKVHINK DDIVAYSPIL
110 120 130 140 150
EKYVGKDITL KALIEASMTY SDNTANNKII KEIGGIKKVK QRLKELGDKV
160 170 180 190 200
TNPVRYEIEL NYYSPKSKKD TSTPAAFGKT LNKLIANGKL SKENKKFLLD
210 220 230 240 250
LMLNNKSGDT LIKDGVPKDY KVADKSGQAI TYASRNDVAF VYPKGQSEPI
260 270 280
VLVIFTNKDN KSDKPNDKLI SETAKSVMKE F
Length:281
Mass (Da):31,349
Last modified:May 10, 2005 - v1
Checksum:iF82A836773C275FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25252 Genomic DNA Translation: AAA26642.1
M25253 Genomic DNA Translation: AAA26643.1
U58139 Genomic DNA Translation: AAB09464.1
AE017171 Genomic DNA Translation: AAQ17167.1
AY917098 Genomic DNA Translation: AAX99120.1
DQ016067 Genomic DNA Translation: AAY84138.1
FJ231270 Genomic DNA Translation: ACI48602.1
GQ900472 Genomic DNA Translation: ACZ66081.1
GQ900419 Genomic DNA Translation: ACZ68595.1
GQ900481 Genomic DNA Translation: ACZ69112.1
GQ900482 Genomic DNA Translation: ACZ69159.1
GQ900507 Genomic DNA Translation: ACZ69349.1
GQ900378 Genomic DNA Translation: ADA61289.1
GQ900387 Genomic DNA Translation: ADA61657.1
GQ900444 Genomic DNA Translation: ADA79953.1
GQ900489 Genomic DNA Translation: ADA80464.1
GQ900490 Genomic DNA Translation: ADA80509.1
GQ900491 Genomic DNA Translation: ADA80554.1
GQ900492 Genomic DNA Translation: ADA80601.1
GQ900493 Genomic DNA Translation: ADA80654.1
GQ900495 Genomic DNA Translation: ADA80732.1
GQ915266 Genomic DNA Translation: ADA80923.1
GQ915267 Genomic DNA Translation: ADA80974.1
GQ915270 Genomic DNA Translation: ADA81103.1
GQ915270 Genomic DNA Translation: ADA81148.1
GQ915272 Genomic DNA Translation: ADA81178.1
KJ756353 Genomic DNA Translation: AKA87318.2
CP018629 Genomic DNA Translation: AUS76558.1
AB245468 Genomic DNA Translation: BAE94456.1
AB245469 Genomic DNA Translation: BAE94459.1
AP012467 Genomic DNA Translation: BAO01001.1
CVOQ01000036 Genomic DNA Translation: CRI18382.1
FGEC01000001 Genomic DNA Translation: CXN16838.1
LRQH01000091 Genomic DNA Translation: KXA36907.1
MSFF01000058 Genomic DNA Translation: OLF26442.1
RefSeqiNP_878023.1, NC_005054.1
WP_000733283.1, NZ_PKSE01000002.1
YP_003329488.1, NC_013550.1
YP_006937602.1, NC_013319.1
YP_006937751.1, NC_013323.1
YP_006938263.1, NC_013337.1
YP_006938770.1, NC_013352.1
YP_008709799.1, NC_022598.1

Genome annotation databases

EnsemblBacteriaiCRI18382; CRI18382; BN1321_410016
CXE62063; CXE62063; ERS074020_01428
CXL97108; CXL97108; ERS072738_01168
CXN16838; CXN16838; ERS072840_00155
KXA36907; KXA36907; HMPREF3211_01027
OAP75147; OAP75147; A4U86_05910
GeneIDi13874750
13874903
13875430
13875951
17363235
2598287
29754060
8655740
PATRICifig|1280.3358.peg.2813

Similar proteinsi

Entry informationi

Entry nameiQ7BWD2_STAAU
AccessioniPrimary (citable) accession number: Q7BWD2
Secondary accession number(s): A0A1W5IJA8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

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