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Protein
Submitted name:

RifR

Gene

rifR

Organism
Amycolatopsis mediterranei (Nocardia mediterranei)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi3.1.2.20. 313.

Protein family/group databases

ESTHERiamyme-RIFR. Thioesterase.

Names & Taxonomyi

Protein namesi
Submitted name:
RifRImported
Gene namesi
Name:rifRImported
OrganismiAmycolatopsis mediterranei (Nocardia mediterranei)Imported
Taxonomic identifieri33910 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeAmycolatopsis

Interactioni

Protein-protein interaction databases

STRINGi749927.AMED_0648.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FLAX-ray1.80A/B1-259[»]
3FLBX-ray1.80A1-259[»]
ProteinModelPortaliQ7BUF9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7BUF9.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108VTW. Bacteria.
COG3208. LUCA.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR020802. PKS_thioesterase.
IPR012223. TEII.
IPR001031. Thioesterase.
[Graphical view]
PANTHERiPTHR11487. PTHR11487. 1 hit.
PfamiPF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00824. PKS_TE. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7BUF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRPEAEKWL RRFERAPDAR ARLVCLPHAG GSASFFFPLA KALAPAVEVL
60 70 80 90 100
AVQYPGRQDR RHEPPVDSIG GLTNRLLEVL RPFGDRPLAL FGHSMGAIIG
110 120 130 140 150
YELALRMPEA GLPAPVHLFA SGRRAPSRYR DDDVRGASDE RLVAELRKLG
160 170 180 190 200
GSDAAMLADP ELLAMVLPAI RSDYRAVETY RHEPGRRVDC PVTVFTGDHD
210 220 230 240 250
PRVSVGEARA WEEHTTGPAD LRVLPGGHFF LVDQAAPMIA TMTEKLAGPA

LTGSTGGNS
Length:259
Mass (Da):28,166
Last modified:July 5, 2004 - v1
Checksum:i45CDBD02D2C35C81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040570 Genomic DNA. Translation: AAG52991.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040570 Genomic DNA. Translation: AAG52991.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FLAX-ray1.80A/B1-259[»]
3FLBX-ray1.80A1-259[»]
ProteinModelPortaliQ7BUF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi749927.AMED_0648.

Protein family/group databases

ESTHERiamyme-RIFR. Thioesterase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108VTW. Bacteria.
COG3208. LUCA.

Enzyme and pathway databases

BRENDAi3.1.2.20. 313.

Miscellaneous databases

EvolutionaryTraceiQ7BUF9.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR020802. PKS_thioesterase.
IPR012223. TEII.
IPR001031. Thioesterase.
[Graphical view]
PANTHERiPTHR11487. PTHR11487. 1 hit.
PfamiPF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00824. PKS_TE. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699."
    August P.R., Tang L., Yoon Y.J., Ning S., Mueller R., Yu T.W., Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R., Floss H.G.
    Chem. Biol. 5:69-79(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  2. "3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics."
    Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G.
    J. Biol. Chem. 273:6030-6040(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  3. "Rifamycin insusceptibility: exploring the rif gene cluster of Amycolatopsis mediterranei S699."
    Yu T.-W., Pogosova-Agadjanyan E.L., Kuan L.-Y., Bai L., Tin A.M., Adman E., Floss H.G.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  4. "Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699."
    Yu T.W., Muller R., Muller M., Zhang X., Draeger G., Kim C.G., Leistner E., Floss H.G.
    J. Biol. Chem. 276:12546-12555(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: S699Imported.
  6. "Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway."
    Claxton H.B., Akey D.L., Silver M.K., Admiraal S.J., Smith J.L.
    J. Biol. Chem. 284:5021-5029(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).

Entry informationi

Entry nameiQ7BUF9_AMYMD
AccessioniPrimary (citable) accession number: Q7BUF9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.