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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation1 Publication

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Transition state stabilizerUniRule annotation1
Active sitei103Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2386 EcoH7CP02_EDL933

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Synonyms:katP
Ordered Locus Names:L7017, ECO57PM75
Encoded oniPlasmid pO1573 Publications
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Plasmid pO157
  • UP000002519 Componenti: Plasmid pO157

Subcellular locationi

  • Periplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_000035478224 – 736Catalase-peroxidase 2Add BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-102)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.L7017

Structurei

3D structure databases

ProteinModelPortaliQ7BSW8
SMRiQ7BSW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiEPEEIFW

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7BSW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKTLPVLI LLALSGSFST AVAADKKETQ NFYYPETLDL TPLRLHSPES
60 70 80 90 100
NPWGADFDYA TRFQQLDMEA LKKDIKDLLT TSQDWWPADY GHYGPFFIRM
110 120 130 140 150
AWHGAGTYRT YDGRGGASGG QQRFEPLNSW PDNVNLDKAR RLLWPVKKKY
160 170 180 190 200
GSSISWGDLM VLTGNVALES MGFKTLGFAG GREDDWESDL VYWGPDNKPL
210 220 230 240 250
ADNRDKNGKL QKPLAATQMG LIYVNPEGPG GKPDPLASAK DIREAFSRMA
260 270 280 290 300
MDDEETVALI AGGHTFGKAH GAASPEKCIG AGPDGAPVEE QGLGWKNKCG
310 320 330 340 350
TGNGKYTITS GLEGAWSTSP TQFTMQYLKN LYKYEWELHK SPAGAYQWKP
360 370 380 390 400
KKAANIVQDA HDPSVLHPLM MFTTDIALKV DPEYKKITTR FLNDPKAFEQ
410 420 430 440 450
AFARAWFKLT HRDMGPAARY LGNEVPAESF IWQDPLPAAD YTMIDGKDIK
460 470 480 490 500
SLKEQVMDLG IPASELIKTA WASASTFRVT DYRGGNNGAR IRLQPEINWE
510 520 530 540 550
VNEPEKLKKV LASLTSLQRE FNKKQSDGKK VSLADLIVLS GNAAIEDAAR
560 570 580 590 600
KAGVELEIPF TPGRTDASQE QTDVASFSVL EPTADGFRNY YSKSRSHISP
610 620 630 640 650
VESLIDKASQ LDLTVPEMTA LLGGLRVMDI NTNNSSLGVF TDTPGVLDNK
660 670 680 690 700
FFVNLLDMST RWSKADKEDT YNGFDRKTGA LKWKASSVDL IFSSNPELRA
710 720 730
VAEVYASDDA RNKFIHDFVK SWNKVMNSDR FDLNNK
Length:736
Mass (Da):81,794
Last modified:July 5, 2004 - v1
Checksum:iF3EA593D3FDEDB8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89017 Genomic DNA Translation: CAA61429.1
AF074613 Genomic DNA Translation: AAC70085.1
AB011549 Genomic DNA Translation: BAA31832.1
PIRiT00313
RefSeqiWP_000592771.1, NZ_NOKN01000004.1
YP_002756743.1, NC_012487.1

Genome annotation databases

EnsemblBacteriaiAAC70085; AAC70085; Z_L7017
BAA31832; BAA31832; BAA31832
GeneIDi7701572
KEGGiece:Z_L7017
PATRICifig|83334.175.peg.3529

Similar proteinsi

Entry informationi

Entry nameiKATG2_ECO57
AccessioniPrimary (citable) accession number: Q7BSW8
Secondary accession number(s): P77038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
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Main funding by: National Institutes of Health