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Protein
Submitted name:

Cag alpha

Gene

cag-alfa

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611ADPCombined sources
Binding sitei133 – 1331ADPCombined sources
Binding sitei140 – 1401ADPCombined sources
Binding sitei145 – 1451ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi181 – 1866ADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Cag alphaImported
Submitted name:
Cag pathogenicity island proteinImported
Submitted name:
Cag-alfaImported
Submitted name:
CagAlpha proteinImported
Submitted name:
Uncharacterized proteinImported
Submitted name:
VirB11-like proteinImported
Gene namesi
Name:cag-alfaImported
Synonyms:cag-alphaImported, cagAlphaImported, virB11Imported
ORF Names:AC785_03890Imported, ACM25_02070Imported, ACM37_01770Imported, AEY53_03685Imported, AM497_06540Imported, AM498_02085Imported, HP0525Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000037143 Componenti: Unassembled WGS sequence
  • UP000037767 Componenti: Unassembled WGS sequence
  • UP000037689 Componenti: Unassembled WGS sequence
  • UP000036805 Componenti: Unassembled WGS sequence
  • UP000036852 Componenti: Unassembled WGS sequence
  • UP000037565 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HP_1451O259903EBI-528063,EBI-528082From a different organism.

Protein-protein interaction databases

MINTiMINT-165082.
STRINGi85963.jhp0474.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G6OX-ray2.50A/B1-330[»]
1NLYX-ray2.80A/B1-330[»]
1NLZX-ray3.00A/B/C/D/E/F1-330[»]
1OPXX-ray2.80A/B1-330[»]
2PT7X-ray2.40A/B/C/D/E/F1-330[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 317282T2SP_EInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4108JB6. Bacteria.
COG0630. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7BK04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDRLSAED KKFLEVERAL KEAALNPLRH ATEELFGDFL KMENITEICY
60 70 80 90 100
NGNKVVWVLK NNGEWQPFDV RDRKAFSLSR LMHFARCCAS FKKKTIDNYE
110 120 130 140 150
NPILSSNLAN GERVQIVLSP VTVNDETISI SIRIPSKTTY PHSFFEEQGF
160 170 180 190 200
YNLLDNKEQA ISAIKDGIAI GKNVIVCGGT GSGKTTYIKS IMEFIPKEER
210 220 230 240 250
IISIEDTEEI VFKHHKNYTQ LFFGGNITSA DCLKSCLRMR PDRIILGELR
260 270 280 290 300
SSEAYDFYNV LCSGHKGTLT TLHAGSSEEA FIRLANMSSS NSAARNIKFE
310 320 330
SLIEGFKDLI DMIVHINHHK QCDEFYIKHR
Length:330
Mass (Da):37,580
Last modified:July 5, 2004 - v1
Checksum:i8B7B2DD8870DA121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282852 Genomic DNA. Translation: AAF80196.1.
AY330638 Genomic DNA. Translation: AAR03888.1.
AY330643 Genomic DNA. Translation: AAR03948.1.
DQ985738 Genomic DNA. Translation: ABJ98418.1.
JQ685155 Genomic DNA. Translation: AGC69807.1.
AB120424 Genomic DNA. Translation: BAD13996.1.
FR666831 Genomic DNA. Translation: CBV36069.1.
FR666838 Genomic DNA. Translation: CBV36233.1.
FR666839 Genomic DNA. Translation: CBV36262.1.
LFCA01000009 Genomic DNA. Translation: KMZ51218.1.
LFKG01000003 Genomic DNA. Translation: KNE08188.1.
LFLE01000019 Genomic DNA. Translation: KNE24670.1.
LFIS01000009 Genomic DNA. Translation: KNX46114.1.
LIXG01000033 Genomic DNA. Translation: KOS32209.1.
LIXF01000007 Genomic DNA. Translation: KOS35664.1.
PIRiE64585.
RefSeqiWP_000133885.1. NZ_LIXG01000033.1.

Genome annotation databases

EnsemblBacteriaiKMZ51218; KMZ51218; AC785_03890.
KNE08188; KNE08188; ACM25_02070.
KNE24670; KNE24670; ACM37_01770.
KNX46114; KNX46114; AEY53_03685.
KOS32209; KOS32209; AM497_06540.
KOS35664; KOS35664; AM498_02085.
PATRICi20592325. VBIHelPyl33062_0551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282852 Genomic DNA. Translation: AAF80196.1.
AY330638 Genomic DNA. Translation: AAR03888.1.
AY330643 Genomic DNA. Translation: AAR03948.1.
DQ985738 Genomic DNA. Translation: ABJ98418.1.
JQ685155 Genomic DNA. Translation: AGC69807.1.
AB120424 Genomic DNA. Translation: BAD13996.1.
FR666831 Genomic DNA. Translation: CBV36069.1.
FR666838 Genomic DNA. Translation: CBV36233.1.
FR666839 Genomic DNA. Translation: CBV36262.1.
LFCA01000009 Genomic DNA. Translation: KMZ51218.1.
LFKG01000003 Genomic DNA. Translation: KNE08188.1.
LFLE01000019 Genomic DNA. Translation: KNE24670.1.
LFIS01000009 Genomic DNA. Translation: KNX46114.1.
LIXG01000033 Genomic DNA. Translation: KOS32209.1.
LIXF01000007 Genomic DNA. Translation: KOS35664.1.
PIRiE64585.
RefSeqiWP_000133885.1. NZ_LIXG01000033.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G6OX-ray2.50A/B1-330[»]
1NLYX-ray2.80A/B1-330[»]
1NLZX-ray3.00A/B/C/D/E/F1-330[»]
1OPXX-ray2.80A/B1-330[»]
2PT7X-ray2.40A/B/C/D/E/F1-330[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-165082.
STRINGi85963.jhp0474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKMZ51218; KMZ51218; AC785_03890.
KNE08188; KNE08188; ACM25_02070.
KNE24670; KNE24670; ACM37_01770.
KNX46114; KNX46114; AEY53_03685.
KOS32209; KOS32209; AM497_06540.
KOS35664; KOS35664; AM498_02085.
PATRICi20592325. VBIHelPyl33062_0551.

Phylogenomic databases

eggNOGiENOG4108JB6. Bacteria.
COG0630. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors."
    Censini S., Lange C., Xiang Z., Crabtree J.E., Ghiara P., Borodovsky M., Rappuoli R., Covacci A.
    Proc. Natl. Acad. Sci. U.S.A. 93:14648-14653(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCUG 17874Imported.
  2. "Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell."
    Covacci A., Rappuoli R.
    J. Exp. Med. 191:587-592(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCUG 17874Imported.
  3. "Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system."
    Yeo H.J., Savvides S.N., Herr A.B., Lanka E., Waksman G.
    Mol. Cell 6:1461-1472(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH ADP.
  4. "VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion."
    Savvides S.N., Yeo H.J., Beck M.R., Blaesing F., Lurz R., Lanka E., Buhrdorf R., Fischer W., Haas R., Waksman G.
    EMBO J. 22:1969-1980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS).
  5. "Comparative analysis of the complete cag pathogenicity island sequence in four Helicobacter pylori isolates."
    Blomstergren A., Lundin A., Nilsson C., Engstrand L., Lundeberg J.
    Gene 328:85-93(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Ca73Imported and Du23:2Imported.
  6. "Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan."
    Azuma T., Yamakawa A., Yamazaki S., Ohtani M., Ito Y., Muramatsu A., Suto H., Yamazaki Y., Keida Y., Higashi H., Hatakeyama M.
    J. Clin. Microbiol. 42:2508-2517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: OK109Imported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3KImported.
  8. "Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase."
    Hare S., Fischer W., Williams R., Terradot L., Bayliss R., Haas R., Waksman G.
    EMBO J. 26:4926-4934(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
  9. "A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island."
    Olbermann P., Josenhans C., Moodley Y., Uhr M., Stamer C., Vauterin M., Suerbaum S., Achtman M., Linz B.
    PLoS Genet. 6:xx-xx(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FIN9624Imported, KAZ3173Imported and L7Imported.
  10. "Functional Plasticity in the Type IV Secretion System of Helicobacter pylori."
    Barrozo R.M., Cooke C.L., Hansen L.M., Lam A.M., Gaddy J.A., Johnson E.M., Cariaga T.A., Suarez G., Peek R.M.Jr., Cover T.L., Solnick J.V.
    PLoS Pathog. 9:E1003189-E1003189(2013)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: J166Imported.
  11. "In silico identification of multidrug resistance associated genes in Helicobacter pylori strains based on comparative genomics approach."
    Loke M.F., Vadivelu J., Tay A.C.Y., Thirriot F., Lee W.C., Goh K.L., Teh X.
    Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UM139Imported, UM147Imported, UM152Imported and UM211Imported.
  12. "Comparative genomics of Helicobacter pylori strains."
    Kumar N., Albert M.J., Al-Akbal H.M., Ahmed N.
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 22Imported and 45Imported.

Entry informationi

Entry nameiQ7BK04_HELPX
AccessioniPrimary (citable) accession number: Q7BK04
Secondary accession number(s): P96528
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.