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Q7BF86

- ARND_YERPS

UniProt

Q7BF86 - ARND_YERPS

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Protein
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Gene
arnD, YPTB2327
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides By similarity.UniRule annotation

Catalytic activityi

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

GO - Biological processi

  1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
  3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-2413-MONOMER.
UniPathwayiUPA00030.
UPA00036; UER00496.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (EC:3.5.1.n3)
Gene namesi
Name:arnD
Ordered Locus Names:YPTB2327
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation
PRO_0000383556Add
BLAST

Expressioni

Inductioni

Activated by low magnesium concentrations, via the two-component regulatory system PhoP/PhoQ.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi273123.YPTB2327.

Structurei

3D structure databases

ProteinModelPortaliQ7BF86.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 261260NodB homology
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0726.
HOGENOMiHOG000261199.
KOiK13014.
OMAiLHAWDHF.
OrthoDBiEOG6423D0.

Family and domain databases

Gene3Di3.20.20.370. 2 hits.
HAMAPiMF_01870. ArnD.
InterProiIPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
PfamiPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 2 hits.
PROSITEiPS51677. NODB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7BF86-1 [UniParc]FASTAAdd to Basket

« Hide

MKQVGLRIDV DTYRGTQYGV PSLLTVLEKH DIRASFFFSV GPDNMGRHLW    50
RLFRPRFLWK MLRSNAASLY GWDILLAGTA WPGKKIAKDF GPLMKAAAMA 100
GHEVGLHAWD HQGWQANVAS WSQQQLTEQV QRGVDTLQQS IGQPISCSAA 150
AGWRADERVL AVKQQFDFSY NSDCRGTHPF RPLLPNGSLG SVQIPVTLPT 200
YDEVVGGEVQ AENFNDFIID AILRDSGVSV YTIHAEVEGM SQAAMFEQLL 250
MRAKQQDIEF CPLSKLLPSD LQLLPVGKVI RAAFPGREGW LGCQSDIKDA 300
E 301
Length:301
Mass (Da):33,504
Last modified:July 5, 2004 - v1
Checksum:iABA3A1132D09A864
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF336802 Genomic DNA. Translation: AAK69643.1.
BX936398 Genomic DNA. Translation: CAH21565.1.
RefSeqiYP_070842.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH21565; CAH21565; YPTB2327.
GeneIDi2956284.
KEGGiyps:YPTB2327.
PATRICi18643570. VBIYerPse22266_2843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF336802 Genomic DNA. Translation: AAK69643.1 .
BX936398 Genomic DNA. Translation: CAH21565.1 .
RefSeqi YP_070842.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q7BF86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB2327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH21565 ; CAH21565 ; YPTB2327 .
GeneIDi 2956284.
KEGGi yps:YPTB2327.
PATRICi 18643570. VBIYerPse22266_2843.

Phylogenomic databases

eggNOGi COG0726.
HOGENOMi HOG000261199.
KOi K13014.
OMAi LHAWDHF.
OrthoDBi EOG6423D0.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00036 ; UER00496 .
BioCyci YPSE273123:GI1M-2413-MONOMER.

Family and domain databases

Gene3Di 3.20.20.370. 2 hits.
HAMAPi MF_01870. ArnD.
InterProi IPR023557. ArnD.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view ]
Pfami PF01522. Polysacc_deac_1. 1 hit.
[Graphical view ]
SUPFAMi SSF88713. SSF88713. 2 hits.
PROSITEi PS51677. NODB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The pmrF polymyxin-resistance operon of Yersinia pseudotuberculosis is upregulated by the PhoP-PhoQ two-component system but not by PmrA-PmrB, and is not required for virulence."
    Marceau M.B., Sebbane F., Ewann F., Collyn F., Lindner B., Campos M.A., Bengoechea J.-A., Simonet M.
    Microbiology 150:3947-3957(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: 32777 / IP2777 / Serotype O1:b.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiARND_YERPS
AccessioniPrimary (citable) accession number: Q7BF86
Secondary accession number(s): Q66A05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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