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Q7BF86

- ARND_YERPS

UniProt

Q7BF86 - ARND_YERPS

Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    4. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciYPSE273123:GI1M-2413-MONOMER.
    UniPathwayiUPA00030.
    UPA00036; UER00496.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
    Gene namesi
    Name:arnDUniRule annotation
    Ordered Locus Names:YPTB2327
    OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
    Taxonomic identifieri273123 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001011: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000383556Add
    BLAST

    Expressioni

    Inductioni

    Activated by low magnesium concentrations, via the two-component regulatory system PhoP/PhoQ.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi273123.YPTB2327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7BF86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 261260NodB homologyUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
    Contains 1 NodB homology domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0726.
    HOGENOMiHOG000261199.
    KOiK13014.
    OMAiLHAWDHF.
    OrthoDBiEOG6423D0.

    Family and domain databases

    Gene3Di3.20.20.370. 2 hits.
    HAMAPiMF_01870. ArnD.
    InterProiIPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view]
    PfamiPF01522. Polysacc_deac_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF88713. SSF88713. 2 hits.
    PROSITEiPS51677. NODB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7BF86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQVGLRIDV DTYRGTQYGV PSLLTVLEKH DIRASFFFSV GPDNMGRHLW    50
    RLFRPRFLWK MLRSNAASLY GWDILLAGTA WPGKKIAKDF GPLMKAAAMA 100
    GHEVGLHAWD HQGWQANVAS WSQQQLTEQV QRGVDTLQQS IGQPISCSAA 150
    AGWRADERVL AVKQQFDFSY NSDCRGTHPF RPLLPNGSLG SVQIPVTLPT 200
    YDEVVGGEVQ AENFNDFIID AILRDSGVSV YTIHAEVEGM SQAAMFEQLL 250
    MRAKQQDIEF CPLSKLLPSD LQLLPVGKVI RAAFPGREGW LGCQSDIKDA 300
    E 301
    Length:301
    Mass (Da):33,504
    Last modified:July 5, 2004 - v1
    Checksum:iABA3A1132D09A864
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336802 Genomic DNA. Translation: AAK69643.1.
    BX936398 Genomic DNA. Translation: CAH21565.1.
    RefSeqiYP_070842.1. NC_006155.1.

    Genome annotation databases

    EnsemblBacteriaiCAH21565; CAH21565; YPTB2327.
    GeneIDi2956284.
    KEGGiyps:YPTB2327.
    PATRICi18643570. VBIYerPse22266_2843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF336802 Genomic DNA. Translation: AAK69643.1 .
    BX936398 Genomic DNA. Translation: CAH21565.1 .
    RefSeqi YP_070842.1. NC_006155.1.

    3D structure databases

    ProteinModelPortali Q7BF86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273123.YPTB2327.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH21565 ; CAH21565 ; YPTB2327 .
    GeneIDi 2956284.
    KEGGi yps:YPTB2327.
    PATRICi 18643570. VBIYerPse22266_2843.

    Phylogenomic databases

    eggNOGi COG0726.
    HOGENOMi HOG000261199.
    KOi K13014.
    OMAi LHAWDHF.
    OrthoDBi EOG6423D0.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00036 ; UER00496 .
    BioCyci YPSE273123:GI1M-2413-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.370. 2 hits.
    HAMAPi MF_01870. ArnD.
    InterProi IPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view ]
    Pfami PF01522. Polysacc_deac_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88713. SSF88713. 2 hits.
    PROSITEi PS51677. NODB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The pmrF polymyxin-resistance operon of Yersinia pseudotuberculosis is upregulated by the PhoP-PhoQ two-component system but not by PmrA-PmrB, and is not required for virulence."
      Marceau M.B., Sebbane F., Ewann F., Collyn F., Lindner B., Campos M.A., Bengoechea J.-A., Simonet M.
      Microbiology 150:3947-3957(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
      Strain: 32777 / IP2777 / Serotype O1:b.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP32953.

    Entry informationi

    Entry nameiARND_YERPS
    AccessioniPrimary (citable) accession number: Q7BF86
    Secondary accession number(s): Q66A05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3