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Protein

Polar-differentiation response regulator DivK

Gene

divK

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polar-differentiation response regulator DivK
Gene namesi
Name:divK
Ordered Locus Names:BruAb2_0613
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Lethal.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53D → A: Abolishes phosphorylation and localization to the cell pole. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003632061 – 123Polar-differentiation response regulator DivKAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with DivL, PleC, DivJ and PdhS.1 Publication

Protein-protein interaction databases

IntActiQ7BBW0. 3 interactors.
MINTiMINT-4507690.

Structurei

3D structure databases

ProteinModelPortaliQ7BBW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000034820.
KOiK11443.
OMAiAHGYQTS.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7BBW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSVMIVED NELNMKLFRD LIEASGYETI RTRSGLEALD LAREHHPDLI
60 70 80 90 100
LMDIQLPEVS GLEVTKWLKD DEELRHIPVI AVTAFAMKGD EERIRQGGCE
110 120
AYISKPISVP RFIETIKSYL GDA
Length:123
Mass (Da):13,973
Last modified:July 5, 2004 - v1
Checksum:i0D74511EB774FA24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92E → R in AAF14690 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051940 mRNA. Translation: AAF14690.1.
AF411569 Genomic DNA. Translation: AAL86375.1.
AE017224 Genomic DNA. Translation: AAX76024.1.
RefSeqiWP_002966022.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX76024; AAX76024; BruAb2_0613.
GeneIDi3828149.
KEGGibmb:BruAb2_0613.
PATRICi17827503. VBIBruAbo15061_2926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051940 mRNA. Translation: AAF14690.1.
AF411569 Genomic DNA. Translation: AAL86375.1.
AE017224 Genomic DNA. Translation: AAX76024.1.
RefSeqiWP_002966022.1. NC_006933.1.

3D structure databases

ProteinModelPortaliQ7BBW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7BBW0. 3 interactors.
MINTiMINT-4507690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX76024; AAX76024; BruAb2_0613.
GeneIDi3828149.
KEGGibmb:BruAb2_0613.
PATRICi17827503. VBIBruAbo15061_2926.

Phylogenomic databases

HOGENOMiHOG000034820.
KOiK11443.
OMAiAHGYQTS.

Miscellaneous databases

PROiQ7BBW0.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIVK_BRUAB
AccessioniPrimary (citable) accession number: Q7BBW0
Secondary accession number(s): Q578B0, Q9RHA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.