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Q7BBW0 (DIVK_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polar-differentiation response regulator DivK
Gene names
Name:divK
Ordered Locus Names:BruAb2_0613
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length123 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS. Ref.4

Subunit structure

Interacts with DivL, PleC, DivJ and PdhS. Ref.4

Subcellular location

Cytoplasm. Note: Localized at one pole of the cell. Colocalizes with PdhS. Ref.4

Disruption phenotype

Lethal. Ref.4

Sequence similarities

Contains 1 response regulatory domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 123123Polar-differentiation response regulator DivK
PRO_0000363206

Regions

Domain4 – 120117Response regulatory

Amino acid modifications

Modified residue5314-aspartylphosphate

Experimental info

Mutagenesis531D → A: Abolishes phosphorylation and localization to the cell pole. Ref.4
Sequence conflict921E → R in AAF14690. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7BBW0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0D74511EB774FA24

FASTA12313,973
        10         20         30         40         50         60 
MTKSVMIVED NELNMKLFRD LIEASGYETI RTRSGLEALD LAREHHPDLI LMDIQLPEVS 

        70         80         90        100        110        120 
GLEVTKWLKD DEELRHIPVI AVTAFAMKGD EERIRQGGCE AYISKPISVP RFIETIKSYL 


GDA 

« Hide

References

« Hide 'large scale' references
[1]"A phosphorelay in Brucella species."
Devos D.P., Rousseau C., Depiereux E., Letesson J.-J.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus."
Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J., Letesson J.J., De Bolle X.
Mol. Microbiol. 43:945-960(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 544 / Biovar 1.
[3]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.
[4]"The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus."
Hallez R., Mignolet J., Van Mullem V., Wery M., Vandenhaute J., Letesson J.-J., Jacobs-Wagner C., De Bolle X.
EMBO J. 26:1444-1455(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CONTROL OF CELL SHAPE, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH DIVL/PLEC/DIVJ/PDHS, MUTAGENESIS OF ASP-53.
Strain: 544 / Biovar 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF051940 mRNA. Translation: AAF14690.1.
AF411569 Genomic DNA. Translation: AAL86375.1.
AE017224 Genomic DNA. Translation: AAX76024.1.
RefSeqYP_223385.1. NC_006933.1.

3D structure databases

ProteinModelPortalQ7BBW0.
SMRQ7BBW0. Positions 2-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ7BBW0. 3 interactions.
MINTMINT-4507690.
STRING262698.BruAb2_0613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX76024; AAX76024; BruAb2_0613.
GeneID3342309.
KEGGbmb:BruAb2_0613.
PATRIC17827503. VBIBruAbo15061_2926.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0784.
HOGENOMHOG000034820.
KOK11443.
OMAWIKDDPE.
OrthoDBEOG6G4VQG.

Enzyme and pathway databases

BioCycBABO262698:GJC2-2827-MONOMER.

Family and domain databases

InterProIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ7BBW0.

Entry information

Entry nameDIVK_BRUAB
AccessionPrimary (citable) accession number: Q7BBW0
Secondary accession number(s): Q578B0, Q9RHA3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names