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Q7BBW0

- DIVK_BRUAB

UniProt

Q7BBW0 - DIVK_BRUAB

Protein

Polar-differentiation response regulator DivK

Gene

divK

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2827-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polar-differentiation response regulator DivK
    Gene namesi
    Name:divK
    Ordered Locus Names:BruAb2_0613
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome II

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Localized at one pole of the cell. Colocalizes with PdhS.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Lethal.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi53 – 531D → A: Abolishes phosphorylation and localization to the cell pole. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 123123Polar-differentiation response regulator DivKPRO_0000363206Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 5314-aspartylphosphate1 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with DivL, PleC, DivJ and PdhS.1 Publication

    Protein-protein interaction databases

    IntActiQ7BBW0. 3 interactions.
    MINTiMINT-4507690.
    STRINGi262698.BruAb2_0613.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7BBW0.
    SMRiQ7BBW0. Positions 2-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 120117Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0784.
    HOGENOMiHOG000034820.
    KOiK11443.
    OMAiWIKDDPE.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    InterProiIPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7BBW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSVMIVED NELNMKLFRD LIEASGYETI RTRSGLEALD LAREHHPDLI    50
    LMDIQLPEVS GLEVTKWLKD DEELRHIPVI AVTAFAMKGD EERIRQGGCE 100
    AYISKPISVP RFIETIKSYL GDA 123
    Length:123
    Mass (Da):13,973
    Last modified:July 5, 2004 - v1
    Checksum:i0D74511EB774FA24
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921E → R in AAF14690. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051940 mRNA. Translation: AAF14690.1.
    AF411569 Genomic DNA. Translation: AAL86375.1.
    AE017224 Genomic DNA. Translation: AAX76024.1.
    RefSeqiYP_223385.1. NC_006933.1.

    Genome annotation databases

    EnsemblBacteriaiAAX76024; AAX76024; BruAb2_0613.
    GeneIDi3342309.
    KEGGibmb:BruAb2_0613.
    PATRICi17827503. VBIBruAbo15061_2926.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051940 mRNA. Translation: AAF14690.1 .
    AF411569 Genomic DNA. Translation: AAL86375.1 .
    AE017224 Genomic DNA. Translation: AAX76024.1 .
    RefSeqi YP_223385.1. NC_006933.1.

    3D structure databases

    ProteinModelPortali Q7BBW0.
    SMRi Q7BBW0. Positions 2-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q7BBW0. 3 interactions.
    MINTi MINT-4507690.
    STRINGi 262698.BruAb2_0613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX76024 ; AAX76024 ; BruAb2_0613 .
    GeneIDi 3342309.
    KEGGi bmb:BruAb2_0613.
    PATRICi 17827503. VBIBruAbo15061_2926.

    Phylogenomic databases

    eggNOGi COG0784.
    HOGENOMi HOG000034820.
    KOi K11443.
    OMAi WIKDDPE.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-2827-MONOMER.

    Miscellaneous databases

    PROi Q7BBW0.

    Family and domain databases

    InterProi IPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A phosphorelay in Brucella species."
      Devos D.P., Rousseau C., Depiereux E., Letesson J.-J.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus."
      Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J., Letesson J.J., De Bolle X.
      Mol. Microbiol. 43:945-960(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 544 / Biovar 1.
    3. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.
    4. "The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus."
      Hallez R., Mignolet J., Van Mullem V., Wery M., Vandenhaute J., Letesson J.-J., Jacobs-Wagner C., De Bolle X.
      EMBO J. 26:1444-1455(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CONTROL OF CELL SHAPE, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, PHOSPHORYLATION AT ASP-53, INTERACTION WITH DIVL/PLEC/DIVJ/PDHS, MUTAGENESIS OF ASP-53.
      Strain: 544 / Biovar 1.

    Entry informationi

    Entry nameiDIVK_BRUAB
    AccessioniPrimary (citable) accession number: Q7BBW0
    Secondary accession number(s): Q578B0, Q9RHA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3