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Q7BBW0

- DIVK_BRUAB

UniProt

Q7BBW0 - DIVK_BRUAB

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Protein

Polar-differentiation response regulator DivK

Gene

divK

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphorelay signal transduction system Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polar-differentiation response regulator DivK
Gene namesi
Name:divK
Ordered Locus Names:BruAb2_0613
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

Subcellular locationi

Cytoplasm 1 Publication
Note: Localized at one pole of the cell. Colocalizes with PdhS.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Lethal.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi53 – 531D → A: Abolishes phosphorylation and localization to the cell pole. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Polar-differentiation response regulator DivKPRO_0000363206Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 5314-aspartylphosphate1 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with DivL, PleC, DivJ and PdhS.1 Publication

Protein-protein interaction databases

IntActiQ7BBW0. 3 interactions.
MINTiMINT-4507690.
STRINGi262698.BruAb2_0613.

Structurei

3D structure databases

ProteinModelPortaliQ7BBW0.
SMRiQ7BBW0. Positions 2-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 120117Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0784.
HOGENOMiHOG000034820.
KOiK11443.
OMAiWIKDDPE.
OrthoDBiEOG6G4VQG.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7BBW0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKSVMIVED NELNMKLFRD LIEASGYETI RTRSGLEALD LAREHHPDLI
60 70 80 90 100
LMDIQLPEVS GLEVTKWLKD DEELRHIPVI AVTAFAMKGD EERIRQGGCE
110 120
AYISKPISVP RFIETIKSYL GDA
Length:123
Mass (Da):13,973
Last modified:July 5, 2004 - v1
Checksum:i0D74511EB774FA24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921E → R in AAF14690. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051940 mRNA. Translation: AAF14690.1.
AF411569 Genomic DNA. Translation: AAL86375.1.
AE017224 Genomic DNA. Translation: AAX76024.1.
RefSeqiYP_223385.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX76024; AAX76024; BruAb2_0613.
GeneIDi3342309.
KEGGibmb:BruAb2_0613.
PATRICi17827503. VBIBruAbo15061_2926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051940 mRNA. Translation: AAF14690.1 .
AF411569 Genomic DNA. Translation: AAL86375.1 .
AE017224 Genomic DNA. Translation: AAX76024.1 .
RefSeqi YP_223385.1. NC_006933.1.

3D structure databases

ProteinModelPortali Q7BBW0.
SMRi Q7BBW0. Positions 2-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7BBW0. 3 interactions.
MINTi MINT-4507690.
STRINGi 262698.BruAb2_0613.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX76024 ; AAX76024 ; BruAb2_0613 .
GeneIDi 3342309.
KEGGi bmb:BruAb2_0613.
PATRICi 17827503. VBIBruAbo15061_2926.

Phylogenomic databases

eggNOGi COG0784.
HOGENOMi HOG000034820.
KOi K11443.
OMAi WIKDDPE.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-2827-MONOMER.

Miscellaneous databases

PROi Q7BBW0.

Family and domain databases

InterProi IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A phosphorelay in Brucella species."
    Devos D.P., Rousseau C., Depiereux E., Letesson J.-J.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus."
    Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J., Letesson J.J., De Bolle X.
    Mol. Microbiol. 43:945-960(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 544 / Biovar 1.
  3. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.
  4. "The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus."
    Hallez R., Mignolet J., Van Mullem V., Wery M., Vandenhaute J., Letesson J.-J., Jacobs-Wagner C., De Bolle X.
    EMBO J. 26:1444-1455(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CONTROL OF CELL SHAPE, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, PHOSPHORYLATION AT ASP-53, INTERACTION WITH DIVL/PLEC/DIVJ/PDHS, MUTAGENESIS OF ASP-53.
    Strain: 544 / Biovar 1.

Entry informationi

Entry nameiDIVK_BRUAB
AccessioniPrimary (citable) accession number: Q7BBW0
Secondary accession number(s): Q578B0, Q9RHA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3