Q7AKI6 (AHPD_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	SCO5031
ORF Names:	SCK7.04c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359509
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7AKI6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1CB543F2E1A33E2F	FASTA	178	19,002
	10 20 30 40 50 60 MSLDSLKSAV PDYAKDLKLN LGSVIGNSDL PAQQLWGTVL ATAIASRSPI VLRELEPEAK 70 80 90 100 110 120 ANLSPEAYSA AKSAAAVMAM NNVFYRTRHL LSDHEYGTLR AGLRMNVIGN PGVDKVDFEL 130 140 150 160 170 WSFAVSAING CGMCLDSHEQ VLRKAGVDRE TIQEAFKIAA VVEAVGVTLD AEAVLAAE

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939122 Genomic DNA. Translation: CAC05876.1.
RefSeq	NP_629183.1. NC_003888.3.
3D structure databases
HSSP	HSSP built from PDB template 1ME5 based on UniProtKB P0A5N4.
ProteinModelPortal	Q7AKI6.
SMR	Q7AKI6. Positions 4-176.
ModBase	Search...
Protein family/group databases
PeroxiBase	4586. ScoAhpD.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1100472.
GenomeReviews	Gene locus SCO5031 in contig AL645882_GR.
KEGG	sco:SCO5031.
NMPDR	fig|100226.1.peg.4986.
PATRIC	23739898. VBIStrCoe124346_5109.
Phylogenomic databases
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK902841.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_STRCO

Accession

Primary (citable) accession number: Q7AKI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program