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Q7AJA5

- PKN1_CHLPN

UniProt

Q7AJA5 - PKN1_CHLPN

Protein

Serine/threonine-protein kinase pkn1

Gene

pkn1

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 299ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPNE115711:GI7B-646-MONOMER.
    CPNE115713:GHEY-153-MONOMER.
    CPNE138677:GH8N-151-MONOMER.
    CPNE182082:GH4N-153-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase pkn1 (EC:2.7.11.1)
    Gene namesi
    Name:pkn1
    Ordered Locus Names:CPn_0148, CP_0625, CPj0148, CpB0149
    OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
    Taxonomic identifieri83558 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Serine/threonine-protein kinase pkn1PRO_0000171188Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi115713.CPn0148.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7AJA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 302288Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000035043.
    OMAiFIRYLEC.
    OrthoDBiEOG622PMB.

    Family and domain databases

    Gene3Di3.90.1580.10. 1 hit.
    InterProiIPR016187. C-type_lectin_fold.
    IPR005532. FGE_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF03781. FGE-sulfatase. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7AJA5-1 [UniParc]FASTAAdd to Basket

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    MESEKDIGAK FLGDYRILYR KGQSLWSEDL LAEHRFIKKR YLIRLLLPDL    50
    GSSQPFMEAF HDVVVKLAKL NHPGILSIEN VSESEGRCFL VTQEQDIPIL 100
    SLTQYLKSIP RKLTELEIVD IVSQLASLLD YVHSEGLAQE EWNLDSVYIH 150
    ILNGVPKVIL PDLGFASLIK ERILDGFISD EENRESKIKE RVLLHTSEGK 200
    QGREDTYAFG AITYYLLFGF LPQGIFPMPS KVFSDFIYDW DFLISSCLSC 250
    FMEERAKELF PLIRKKTLGE ELQNVVTNCI ESSLREVPDP LESSQNLPQA 300
    VLKVGETKVS HQQKESAEHL EFVLVEACSI DEAMDTAIES ESSSGVEEEG 350
    YSLALQSLLV REPVVSRYVE AEKEEPKPQP ILTEMVLIEG GEFSRGSVEG 400
    QRDELPVHKV ILHSFFLDVH PVTNEQFIRY LECCGSEQDK YYNELIRLRD 450
    SRIQRRSGRL VIEPGYAKHP VVGVTWYGAS GYAEWIGKRL PTEAEWEIAA 500
    SGGVAALRYP CGEEIEKSRA NFFTADTTTV MSYPPNPYGL YDMAGNVYEW 550
    CQDWYGYDFY EISAQEPESP QGPAQGVYRV LRGGCWKSLK DDLRCAHRHR 600
    NNPGAVNSTY GFRCAKNIN 619
    Length:619
    Mass (Da):70,355
    Last modified:July 5, 2004 - v1
    Checksum:iCA312E28304D7D80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti309 – 3091V → A in AAF38440. (PubMed:10684935)Curated
    Sequence conflicti515 – 5151I → V in AAP98082. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18301.1.
    AE002161 Genomic DNA. Translation: AAF38440.1.
    BA000008 Genomic DNA. Translation: BAA98358.1.
    AE009440 Genomic DNA. Translation: AAP98082.1.
    PIRiA72114.
    D81556.
    D86509.
    RefSeqiNP_224356.1. NC_000922.1.
    NP_300207.1. NC_002491.1.
    NP_445167.1. NC_002179.2.
    NP_876425.1. NC_005043.1.

    Genome annotation databases

    EnsemblBacteriaiAAD18301; AAD18301; CPn_0148.
    AAF38440; AAF38440; CP_0625.
    AAP98082; AAP98082; CpB0149.
    BAA98358; BAA98358; BAA98358.
    GeneIDi1466832.
    894945.
    918939.
    963272.
    KEGGicpa:CP0625.
    cpj:CPj0148.
    cpn:CPn0148.
    cpt:CpB0149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001363 Genomic DNA. Translation: AAD18301.1 .
    AE002161 Genomic DNA. Translation: AAF38440.1 .
    BA000008 Genomic DNA. Translation: BAA98358.1 .
    AE009440 Genomic DNA. Translation: AAP98082.1 .
    PIRi A72114.
    D81556.
    D86509.
    RefSeqi NP_224356.1. NC_000922.1.
    NP_300207.1. NC_002491.1.
    NP_445167.1. NC_002179.2.
    NP_876425.1. NC_005043.1.

    3D structure databases

    ProteinModelPortali Q7AJA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 115713.CPn0148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD18301 ; AAD18301 ; CPn_0148 .
    AAF38440 ; AAF38440 ; CP_0625 .
    AAP98082 ; AAP98082 ; CpB0149 .
    BAA98358 ; BAA98358 ; BAA98358 .
    GeneIDi 1466832.
    894945.
    918939.
    963272.
    KEGGi cpa:CP0625.
    cpj:CPj0148.
    cpn:CPn0148.
    cpt:CpB0149.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000035043.
    OMAi FIRYLEC.
    OrthoDBi EOG622PMB.

    Enzyme and pathway databases

    BioCyci CPNE115711:GI7B-646-MONOMER.
    CPNE115713:GHEY-153-MONOMER.
    CPNE138677:GH8N-151-MONOMER.
    CPNE182082:GH4N-153-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1580.10. 1 hit.
    InterProi IPR016187. C-type_lectin_fold.
    IPR005532. FGE_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF03781. FGE-sulfatase. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CWL029.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR39.
    3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
      Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
      Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J138.
    4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
      Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW-183.

    Entry informationi

    Entry nameiPKN1_CHLPN
    AccessioniPrimary (citable) accession number: Q7AJA5
    Secondary accession number(s): Q7VQ75, Q9K228, Q9Z935
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3