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Protein

Serine/threonine-protein kinase pkn1

Gene

pkn1

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pkn1 (EC:2.7.11.1)
Gene namesi
Name:pkn1
Ordered Locus Names:CPn_0148, CP_0625, CPj0148, CpB0149
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001711881 – 619Serine/threonine-protein kinase pkn1Add BLAST619

Post-translational modificationi

Autophosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0149

Structurei

3D structure databases

ProteinModelPortaliQ7AJA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 302Protein kinasePROSITE-ProRule annotationAdd BLAST288

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E6M Bacteria
COG0515 LUCA
COG1262 LUCA
HOGENOMiHOG000035043
OMAiTQANFFS
OrthoDBiPOG091H091W

Family and domain databases

InterProiView protein in InterPro
IPR016187 CTDL_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR005532 SUMF_dom
PfamiView protein in Pfam
PF03781 FGE-sulfatase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q7AJA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEKDIGAK FLGDYRILYR KGQSLWSEDL LAEHRFIKKR YLIRLLLPDL
60 70 80 90 100
GSSQPFMEAF HDVVVKLAKL NHPGILSIEN VSESEGRCFL VTQEQDIPIL
110 120 130 140 150
SLTQYLKSIP RKLTELEIVD IVSQLASLLD YVHSEGLAQE EWNLDSVYIH
160 170 180 190 200
ILNGVPKVIL PDLGFASLIK ERILDGFISD EENRESKIKE RVLLHTSEGK
210 220 230 240 250
QGREDTYAFG AITYYLLFGF LPQGIFPMPS KVFSDFIYDW DFLISSCLSC
260 270 280 290 300
FMEERAKELF PLIRKKTLGE ELQNVVTNCI ESSLREVPDP LESSQNLPQA
310 320 330 340 350
VLKVGETKVS HQQKESAEHL EFVLVEACSI DEAMDTAIES ESSSGVEEEG
360 370 380 390 400
YSLALQSLLV REPVVSRYVE AEKEEPKPQP ILTEMVLIEG GEFSRGSVEG
410 420 430 440 450
QRDELPVHKV ILHSFFLDVH PVTNEQFIRY LECCGSEQDK YYNELIRLRD
460 470 480 490 500
SRIQRRSGRL VIEPGYAKHP VVGVTWYGAS GYAEWIGKRL PTEAEWEIAA
510 520 530 540 550
SGGVAALRYP CGEEIEKSRA NFFTADTTTV MSYPPNPYGL YDMAGNVYEW
560 570 580 590 600
CQDWYGYDFY EISAQEPESP QGPAQGVYRV LRGGCWKSLK DDLRCAHRHR
610
NNPGAVNSTY GFRCAKNIN
Length:619
Mass (Da):70,355
Last modified:July 5, 2004 - v1
Checksum:iCA312E28304D7D80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309V → A in AAF38440 (PubMed:10684935).Curated1
Sequence conflicti515I → V in AAP98082 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18301.1
AE002161 Genomic DNA Translation: AAF38440.1
BA000008 Genomic DNA Translation: BAA98358.1
AE009440 Genomic DNA Translation: AAP98082.1
PIRiA72114
D81556
D86509
RefSeqiNP_224356.1, NC_000922.1
WP_010882798.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18301; AAD18301; CPn_0148
AAF38440; AAF38440; CP_0625
AAP98082; AAP98082; CpB0149
BAA98358; BAA98358; BAA98358
GeneIDi894945
KEGGicpa:CP_0625
cpj:CPj0148
cpn:CPn0148
cpt:CpB0149
PATRICifig|115713.3.peg.168

Similar proteinsi

Entry informationi

Entry nameiPKN1_CHLPN
AccessioniPrimary (citable) accession number: Q7AJA5
Secondary accession number(s): Q7VQ75, Q9K228, Q9Z935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health