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Q7AJA5

- PKN1_CHLPN

UniProt

Q7AJA5 - PKN1_CHLPN

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Protein

Serine/threonine-protein kinase pkn1

Gene

pkn1

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 299ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPNE115711:GI7B-646-MONOMER.
CPNE115713:GHEY-153-MONOMER.
CPNE138677:GH8N-151-MONOMER.
CPNE182082:GH4N-153-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pkn1 (EC:2.7.11.1)
Gene namesi
Name:pkn1
Ordered Locus Names:CPn_0148, CP_0625, CPj0148, CpB0149
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000424: Chromosome, UP000000583: Chromosome, UP000000801: Chromosome, UP000000802: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Serine/threonine-protein kinase pkn1PRO_0000171188Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi115713.CPn0148.

Structurei

3D structure databases

ProteinModelPortaliQ7AJA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 302288Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000035043.
OMAiFIRYLEC.
OrthoDBiEOG622PMB.

Family and domain databases

Gene3Di3.90.1580.10. 1 hit.
InterProiIPR016187. C-type_lectin_fold.
IPR005532. FGE_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF03781. FGE-sulfatase. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7AJA5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESEKDIGAK FLGDYRILYR KGQSLWSEDL LAEHRFIKKR YLIRLLLPDL
60 70 80 90 100
GSSQPFMEAF HDVVVKLAKL NHPGILSIEN VSESEGRCFL VTQEQDIPIL
110 120 130 140 150
SLTQYLKSIP RKLTELEIVD IVSQLASLLD YVHSEGLAQE EWNLDSVYIH
160 170 180 190 200
ILNGVPKVIL PDLGFASLIK ERILDGFISD EENRESKIKE RVLLHTSEGK
210 220 230 240 250
QGREDTYAFG AITYYLLFGF LPQGIFPMPS KVFSDFIYDW DFLISSCLSC
260 270 280 290 300
FMEERAKELF PLIRKKTLGE ELQNVVTNCI ESSLREVPDP LESSQNLPQA
310 320 330 340 350
VLKVGETKVS HQQKESAEHL EFVLVEACSI DEAMDTAIES ESSSGVEEEG
360 370 380 390 400
YSLALQSLLV REPVVSRYVE AEKEEPKPQP ILTEMVLIEG GEFSRGSVEG
410 420 430 440 450
QRDELPVHKV ILHSFFLDVH PVTNEQFIRY LECCGSEQDK YYNELIRLRD
460 470 480 490 500
SRIQRRSGRL VIEPGYAKHP VVGVTWYGAS GYAEWIGKRL PTEAEWEIAA
510 520 530 540 550
SGGVAALRYP CGEEIEKSRA NFFTADTTTV MSYPPNPYGL YDMAGNVYEW
560 570 580 590 600
CQDWYGYDFY EISAQEPESP QGPAQGVYRV LRGGCWKSLK DDLRCAHRHR
610
NNPGAVNSTY GFRCAKNIN
Length:619
Mass (Da):70,355
Last modified:July 5, 2004 - v1
Checksum:iCA312E28304D7D80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091V → A in AAF38440. (PubMed:10684935)Curated
Sequence conflicti515 – 5151I → V in AAP98082. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18301.1.
AE002161 Genomic DNA. Translation: AAF38440.1.
BA000008 Genomic DNA. Translation: BAA98358.1.
AE009440 Genomic DNA. Translation: AAP98082.1.
PIRiA72114.
D81556.
D86509.
RefSeqiNP_224356.1. NC_000922.1.
NP_300207.1. NC_002491.1.
NP_445167.1. NC_002179.2.
NP_876425.1. NC_005043.1.

Genome annotation databases

EnsemblBacteriaiAAD18301; AAD18301; CPn_0148.
AAF38440; AAF38440; CP_0625.
AAP98082; AAP98082; CpB0149.
BAA98358; BAA98358; BAA98358.
GeneIDi1466832.
894945.
918939.
963272.
KEGGicpa:CP0625.
cpj:CPj0148.
cpn:CPn0148.
cpt:CpB0149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA. Translation: AAD18301.1 .
AE002161 Genomic DNA. Translation: AAF38440.1 .
BA000008 Genomic DNA. Translation: BAA98358.1 .
AE009440 Genomic DNA. Translation: AAP98082.1 .
PIRi A72114.
D81556.
D86509.
RefSeqi NP_224356.1. NC_000922.1.
NP_300207.1. NC_002491.1.
NP_445167.1. NC_002179.2.
NP_876425.1. NC_005043.1.

3D structure databases

ProteinModelPortali Q7AJA5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 115713.CPn0148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD18301 ; AAD18301 ; CPn_0148 .
AAF38440 ; AAF38440 ; CP_0625 .
AAP98082 ; AAP98082 ; CpB0149 .
BAA98358 ; BAA98358 ; BAA98358 .
GeneIDi 1466832.
894945.
918939.
963272.
KEGGi cpa:CP0625.
cpj:CPj0148.
cpn:CPn0148.
cpt:CpB0149.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000035043.
OMAi FIRYLEC.
OrthoDBi EOG622PMB.

Enzyme and pathway databases

BioCyci CPNE115711:GI7B-646-MONOMER.
CPNE115713:GHEY-153-MONOMER.
CPNE138677:GH8N-151-MONOMER.
CPNE182082:GH4N-153-MONOMER.

Family and domain databases

Gene3Di 3.90.1580.10. 1 hit.
InterProi IPR016187. C-type_lectin_fold.
IPR005532. FGE_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF03781. FGE-sulfatase. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CWL029.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR39.
  3. "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA."
    Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K., Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.
    Nucleic Acids Res. 28:2311-2314(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J138.
  4. "The genome sequence of Chlamydia pneumoniae TW183 and comparison with other Chlamydia strains based on whole genome sequence analysis."
    Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P., Schneider S., Pohl T., Essig A., Marre R., Melchers K.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW-183.

Entry informationi

Entry nameiPKN1_CHLPN
AccessioniPrimary (citable) accession number: Q7AJA5
Secondary accession number(s): Q7VQ75, Q9K228, Q9Z935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3