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Protein

Hexitol phosphatase B

Gene

hxpB

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sugar-phosphate phosphohydrolase that catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate. Also catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate (2dGlu6P); this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2-deoxyglucose.By similarity

Catalytic activityi

Sugar phosphate + H2O = sugar + phosphate.By similarity
2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.By similarity
D-mannitol 1-phosphate + H2O = D-mannitol + phosphate.By similarity
Sorbitol 6-phosphate + H2O = sorbitol + phosphate.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity, Co2+By similarity, Zn2+By similarityNote: Requires the presence of a divalent metal cation for activity. Can use zinc, manganese, cobalt or magnesium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13NucleophileBy similarity1
Metal bindingi13Divalent metal cationBy similarity1
Active sitei15Proton donorBy similarity1
Metal bindingi15Divalent metal cation; via carbonyl oxygenBy similarity1
Binding sitei148SubstrateBy similarity1
Metal bindingi173Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandCobalt, Magnesium, Manganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hexitol phosphatase BBy similarity
Alternative name(s):
2-deoxyglucose-6-phosphate phosphataseBy similarity (EC:3.1.3.68By similarity)
Mannitol-1-phosphataseBy similarity (EC:3.1.3.22By similarity)
Sorbitol-6-phosphataseBy similarity (EC:3.1.3.50By similarity)
Sugar-phosphataseBy similarity (EC:3.1.3.23By similarity)
Gene namesi
Name:hxpBBy similarity
Synonyms:yniC
Ordered Locus Names:Z2756, ECs2433
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB02726 2-Phosphoglycolic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080621 – 222Hexitol phosphatase BAdd BLAST222

Interactioni

Protein-protein interaction databases

STRINGi155864.Z2756

Structurei

3D structure databases

ProteinModelPortaliQ7ADF8
SMRiQ7ADF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 15Substrate bindingBy similarity3
Regioni115 – 116Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107UW8 Bacteria
COG0637 LUCA
KOiK19270
OMAiEPLWDQA

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01509 HAD-SF-IA-v3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7ADF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPRQILAA IFDMDGLLID SEPLWDRAEL DVMASLGVDI SRRNELPDTL
60 70 80 90 100
GLRIDMVVDL WYARQPWNGP SRQEVVERVI ARAISLVEET RPLLPGVREA
110 120 130 140 150
VALCKEQGLL VGLASASPLH MLEKVLTMFD LRDSFDALAS AEKLPYSKPH
160 170 180 190 200
PQVYLDCAAK LGVDPLTCVA LEDSVNGMIA SKAARMRSIV VPAPEAQNDP
210 220
RFVLANVKLS SLTELTAKDL LG
Length:222
Mass (Da):24,329
Last modified:July 5, 2004 - v1
Checksum:i7B937F2A331476A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205A → S in AAG56713 (PubMed:11206551).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56713.1
BA000007 Genomic DNA Translation: BAB35856.1
PIRiA98933
E85781
RefSeqiNP_310460.1, NC_002695.1
WP_000106834.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56713; AAG56713; Z2756
BAB35856; BAB35856; BAB35856
GeneIDi912766
KEGGiece:Z2756
ecs:ECs2433
PATRICifig|386585.9.peg.2547

Similar proteinsi

Entry informationi

Entry nameiHXPB_ECO57
AccessioniPrimary (citable) accession number: Q7ADF8
Secondary accession number(s): Q8XEJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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