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Protein

2-deoxyglucose-6-phosphate phosphatase

Gene

yniC

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate (2dGlu6P).By similarity

Catalytic activityi

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity, Co2+By similarity, Zn2+By similarityNote: Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131NucleophileBy similarity
Metal bindingi13 – 131MagnesiumBy similarity
Metal bindingi15 – 151MagnesiumBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Metal bindingi173 – 1731MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2406-MONOMER.
ECOO157:Z2756-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-deoxyglucose-6-phosphate phosphatase (EC:3.1.3.68)
Gene namesi
Name:yniC
Ordered Locus Names:Z2756, ECs2433
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2222222-deoxyglucose-6-phosphate phosphatasePRO_0000108062Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z2756.

Structurei

3D structure databases

ProteinModelPortaliQ7ADF8.
SMRiQ7ADF8. Positions 5-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 153Substrate bindingBy similarity
Regioni115 – 1162Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107UW8. Bacteria.
COG0637. LUCA.
KOiK19270.
OMAiWYAQQPW.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7ADF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPRQILAA IFDMDGLLID SEPLWDRAEL DVMASLGVDI SRRNELPDTL
60 70 80 90 100
GLRIDMVVDL WYARQPWNGP SRQEVVERVI ARAISLVEET RPLLPGVREA
110 120 130 140 150
VALCKEQGLL VGLASASPLH MLEKVLTMFD LRDSFDALAS AEKLPYSKPH
160 170 180 190 200
PQVYLDCAAK LGVDPLTCVA LEDSVNGMIA SKAARMRSIV VPAPEAQNDP
210 220
RFVLANVKLS SLTELTAKDL LG
Length:222
Mass (Da):24,329
Last modified:July 5, 2004 - v1
Checksum:i7B937F2A331476A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051A → S in AAG56713 (PubMed:11206551).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56713.1.
BA000007 Genomic DNA. Translation: BAB35856.1.
PIRiA98933.
E85781.
RefSeqiNP_310460.1. NC_002695.1.
WP_000106834.1. NZ_LPWC01000357.1.

Genome annotation databases

EnsemblBacteriaiAAG56713; AAG56713; Z2756.
BAB35856; BAB35856; BAB35856.
GeneIDi912766.
KEGGiece:Z2756.
ecs:ECs2433.
PATRICi18354210. VBIEscCol44059_2316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56713.1.
BA000007 Genomic DNA. Translation: BAB35856.1.
PIRiA98933.
E85781.
RefSeqiNP_310460.1. NC_002695.1.
WP_000106834.1. NZ_LPWC01000357.1.

3D structure databases

ProteinModelPortaliQ7ADF8.
SMRiQ7ADF8. Positions 5-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z2756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG56713; AAG56713; Z2756.
BAB35856; BAB35856; BAB35856.
GeneIDi912766.
KEGGiece:Z2756.
ecs:ECs2433.
PATRICi18354210. VBIEscCol44059_2316.

Phylogenomic databases

eggNOGiENOG4107UW8. Bacteria.
COG0637. LUCA.
KOiK19270.
OMAiWYAQQPW.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2406-MONOMER.
ECOO157:Z2756-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYNIC_ECO57
AccessioniPrimary (citable) accession number: Q7ADF8
Secondary accession number(s): Q8XEJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.