Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q7ADE6 (ASTD_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:Z2778, ECs2452
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_0000262400

Regions

Nucleotide binding220 – 2256NAD By similarity

Sites

Active site2431 By similarity
Active site2771 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7ADE6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 147D74C2088D9221

FASTA49252,985
        10         20         30         40         50         60 
MTLWINGDWI TGQGASRVKR NPVSGEVLWQ GNDADAAQVG QACRAARAAF PRWARLSFAE 

        70         80         90        100        110        120 
RQAVVERFAG LLERNKGELT AIIARETGKP RWEAATELTA MINKIAISIK AYHVRTGEQR 

       130        140        150        160        170        180 
SEMPDGAASL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTIIFKPS ELTPWSGEAV 

       190        200        210        220        230        240 
MRLWQQAGLP PGVLNLVQGG CETGQALSAL EDLDGLLFTG SANTGYQLHR QLSGQPEKIL 

       250        260        270        280        290        300 
ALEMGGNNPL IIDEVADIDA AVHLTIQSAF VTAGQRCTCA RRVLLKSGAQ GDAFLARLVA 

       310        320        330        340        350        360 
VSQRLTPGNW DDEPQPFIGG LISEQAAQQV FTAWQQLEAM GGRTLLAPRL LQAGTSLLTP 

       370        380        390        400        410        420 
GIIEMTGVAG VPDEEVFGPL LRVWRYDSFE EAIRMANNTR FGLSCGLVSP EREKFDQLLL 

       430        440        450        460        470        480 
EARAGIVNWN KPLTGAASTA PFGGIGASGN HRPSAWYAAD YCAWPMASLE SDSLTLPATL 

       490 
NPGLDFSDEV VR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG56732.1.
BA000007 Genomic DNA. Translation: BAB35875.1.
PIRD90935.
H85783.
RefSeqNP_288179.1. NC_002655.2.
NP_310479.1. NC_002695.1.

3D structure databases

ProteinModelPortalQ7ADE6.
SMRQ7ADE6. Positions 2-484.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000025386; EBESCP00000024279; EBESCG00000024440.
EBESCT00000059588; EBESCP00000057416; EBESCG00000058635.
GeneID917113.
961717.
GenomeReviewsGene locus Z2778 in contig AE005174_GR.
Gene locus ECs2452 in contig BA000007_GR.
KEGGece:Z2778.
ecs:ECs2452.
PATRIC18354248. VBIEscCol44059_2335.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000009176.
HOGENOMHBG752218.
OMAKAYHART.
ProtClustDBPRK09457.

Enzyme and pathway databases

BioCycECOL83334:ECS2452-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_ECO57
AccessionPrimary (citable) accession number: Q7ADE6
Secondary accession number(s): Q8XDY8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents