Q7A7P2 (LIP2_STAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 2
EC=3.1.1.3

Alternative name(s):
Glycerol ester hydrolase 2

Gene names

Name:	lip2
Synonyms:	geh
Ordered Locus Names:	SA0309

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Propeptide	38 – 296	259	By similarity		PRO_0000045190
	Chain	297 – 691	395	Lipase 2		PRO_0000045191
Sites
	Active site	413	1	Charge relay system By similarity
	Active site	646	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7A7P2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 11F2117D26C54C7A	FASTA	691	76,543
	10 20 30 40 50 60 MLRGQEERKY SIRKYSIGVV SVLAATMFVV SSHEAQASEK TPTSNAAAQK ETLNQPGEQG 70 80 90 100 110 120 NAITSHQMQS GKQLDDMHKE NGKSGTVTEG KDTLQSSKHQ STQNSKTIRT QNDNQVKQDS 130 140 150 160 170 180 ERQGSKQSHQ NNATNNTERQ NDQVQNTHHA ERNGSQSTTS QSNDVDKSQP SIPAQKVLPN 190 200 210 220 230 240 HDKAAPTSTT PPSNDKTAPK STKAQDATTD KHPNQQDTHQ PAHQIIDAKQ DDTVRQSEQK 250 260 270 280 290 300 PQVGDLSKHI DGQNSPEKPT DKNTDNKQLI KDALQAPKTR STTNAAADAK KVRPLKANQV 310 320 330 340 350 360 QPLNKYPVVF VHGFLGLVGD NAPALYPNYW GGNKFKVIEE LRKQGYNVHQ ASVSAFGSNY 370 380 390 400 410 420 DRAVELYYYI KGGRVDYGAA HAAKYGHERY GKTYKGIMPN WEPGKKVHLV GHSMGGQTIR 430 440 450 460 470 480 LMEEFLRNGN KEEIAYHKAH GGEISPLFTG GHNNMVASIT TLATPHNGSQ AADKFGNTEA 490 500 510 520 530 540 VRKIMFALNR FMGNKYSNID LGLTQWGFKQ LPNESYIDYI KRVSKSKIWT SDDNAAYDLT 550 560 570 580 590 600 LDGSAKLNNM TSMNPNITYT TYTGVSSHTG PLGYENPDLG TFFLMDTTSR IIGHDAREEW 610 620 630 640 650 660 RKNDGVVPVI SSLHPSNQPF INVTNDEPAT RRGIWQVKPI IQGWDHVDFI GVDFLDFKRK 670 680 690 GAELANFYTG IINDLLRVEA TESKGTQLKA S

References

[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: N315.
[2]	"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315." Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F. Submitted (OCT-2007) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Strain: N315.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB41533.1.
PIR	B89797.
RefSeq	NP_373555.1. NC_002745.2.
3D structure databases
ProteinModelPortal	Q7A7P2.
SMR	Q7A7P2. Positions 296-683.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7A7P2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000001583; EBSTAP00000001583; EBSTAG00000001583.
GeneID	1123088.
GenomeReviews	Gene locus SA0309 in contig BA000018_GR.
KEGG	sau:SA0309.
PATRIC	19572670. VBIStaAur116463_0324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1075.
GeneTree	EBGT00050000023709.
HOGENOM	HBG694146.
OMA	ETINRIG.
ProtClustDB	CLSK2752181.
Enzyme and pathway databases
BioCyc	SAUR158879:SA0309-MONOMER.
Family and domain databases
InterPro	IPR005877. Gpos_YSIRK. [Graphical view]
KO	K01046.
Pfam	PF04650. YSIRK_signal. 1 hit. [Graphical view]
TIGRFAMs	TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP2_STAAN

Accession

Primary (citable) accession number: Q7A7P2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program