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Q7A7E0

- SLE1_STAAN

UniProt

Q7A7E0 - SLE1_STAAN

Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. barrier septum assembly Source: UniProtKB-KW
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-438-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
    Gene namesi
    Name:sle1
    Synonyms:aaa
    Ordered Locus Names:SA0423
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    Subcellular locationi

    Secreted By similarity. Cell surface By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 334309N-acetylmuramoyl-L-alanine amidase sle1PRO_0000231623Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA0423.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7A7E0.
    SMRiQ7A7E0. Positions 228-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 7143LysM 1Add
    BLAST
    Repeati93 – 13543LysM 2Add
    BLAST
    Repeati160 – 20243LysM 3Add
    BLAST
    Domaini210 – 334125Peptidase C51PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 LysM repeats.Curated
    Contains 1 peptidase C51 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG3942.
    HOGENOMiHOG000279823.
    OMAiEMNYSAS.
    OrthoDBiEOG6GTZPF.

    Family and domain databases

    Gene3Di3.10.350.10. 3 hits.
    InterProiIPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view]
    PfamiPF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view]
    SMARTiSM00257. LysM. 3 hits.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 3 hits.
    PROSITEiPS50911. CHAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7A7E0-1 [UniParc]FASTAAdd to Basket

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    MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK    50
    LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS 100
    LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNAASNSSRP 150
    STNSGGGSYY TVQAGDSLSL IASKYGTTYQ KIMSLNGLNN FFIYPGQKLK 200
    VTGNASTNSG SATTTNRGYN TPVFSHQNLY TWGQCTYHVF NRRAEIGKGI 250
    STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND 300
    GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH 334
    Length:334
    Mass (Da):35,836
    Last modified:July 5, 2004 - v1
    Checksum:i4C1E30AD9DE61D36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB41653.1.
    PIRiB89812.
    RefSeqiNP_373675.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB41653; BAB41653; BAB41653.
    GeneIDi1123208.
    KEGGisau:SA0423.
    PATRICi19572918. VBIStaAur116463_0448.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB41653.1 .
    PIRi B89812.
    RefSeqi NP_373675.1. NC_002745.2.

    3D structure databases

    ProteinModelPortali Q7A7E0.
    SMRi Q7A7E0. Positions 228-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA0423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB41653 ; BAB41653 ; BAB41653 .
    GeneIDi 1123208.
    KEGGi sau:SA0423.
    PATRICi 19572918. VBIStaAur116463_0448.

    Phylogenomic databases

    eggNOGi COG3942.
    HOGENOMi HOG000279823.
    OMAi EMNYSAS.
    OrthoDBi EOG6GTZPF.

    Enzyme and pathway databases

    BioCyci SAUR158879:GJCB-438-MONOMER.

    Family and domain databases

    Gene3Di 3.10.350.10. 3 hits.
    InterProi IPR007921. CHAP_dom.
    IPR018392. LysM_dom.
    [Graphical view ]
    Pfami PF05257. CHAP. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view ]
    SMARTi SM00257. LysM. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 3 hits.
    PROSITEi PS50911. CHAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.
    2. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
      Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
      Submitted (OCT-2007) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: N315.

    Entry informationi

    Entry nameiSLE1_STAAN
    AccessioniPrimary (citable) accession number: Q7A7E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3