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Protein

ATP-dependent Clp protease ATP-binding subunit ClpC

Gene

clpC

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi208 – 2158ATPSequence analysis
Nucleotide bindingi545 – 5528ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-517-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC
Gene namesi
Name:clpC
Ordered Locus Names:SA0483
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818ATP-dependent Clp protease ATP-binding subunit ClpCPRO_0000269684Add
BLAST

Proteomic databases

PRIDEiQ7A797.

Structurei

3D structure databases

ProteinModelPortaliQ7A797.
SMRiQ7A797. Positions 3-801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini417 – 45236UVRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 410248IAdd
BLAST
Regioni471 – 662192IIAdd
BLAST

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated
Contains 1 UVR domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000218210.
OMAiYVGFNIQ.
OrthoDBiEOG65F8SM.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7A797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL
60 70 80 90 100
ESFNITEDKV IEEVEKLIGH GQDHVGTLHY TPRAKKVIEL SMDEARKLHH
110 120 130 140 150
NFVGTEHILL GLIRENEGVA ARVFANLDLN ITKARAQVVK ALGNPEMSNK
160 170 180 190 200
NAQASKSNNT PTLDSLARDL TVIAKDGTLD PVIGRDKEIT RVIEVLSRRT
210 220 230 240 250
KNNPVLIGEP GVGKTAIAEG LAQAIVNNEV PETLKDKRVM SLDMGTVVAG
260 270 280 290 300
TKYRGEFEER LKKVMEEIQQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL
310 320 330 340 350
KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPVQVD EPSVVDTVAI
360 370 380 390 400
LKGLRDRYEA HHRINISDEA IEAAVKLSNR YVSDRFLPDK AIDLIDEASS
410 420 430 440 450
KVRLKSHTTP NNLKEIEQEI EKVKNEKDAA VHAQEFENAA NLRDKQTKLE
460 470 480 490 500
KQYEEAKNEW KNAQNGMSTS LSEEDIAEVI AGWTGIPLTK INETESEKLL
510 520 530 540 550
SLEDTLHERV IGQKDAVNSI SKAVRRARAG LKDPKRPIGS FIFLGPTGVG
560 570 580 590 600
KTELARALAE SMFGDDDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDDGG
610 620 630 640 650
QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRTVDFR
660 670 680 690 700
NTIIIMTSNV GAQELQDQRF AGFGGSSDGQ DYETIRKTML KELKNSFRPE
710 720 730 740 750
FLNRVDDIIV FHKLTKEELK EIVTMMVNKL TNRLSEQNIN IIVTDKAKDK
760 770 780 790 800
IAEEGYDPEY GARPLIRAIQ KTIEDNLSEL ILDGNQIEGK KVTVDHDGKE
810
FKYDIAEQTS ETKTPSQA
Length:818
Mass (Da):91,037
Last modified:July 5, 2004 - v1
Checksum:i404DBB1643BAA31F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41713.1.
PIRiF89819.
RefSeqiWP_000897132.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41713; BAB41713; BAB41713.
PATRICi19573076. VBIStaAur116463_0508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41713.1.
PIRiF89819.
RefSeqiWP_000897132.1. NC_002745.2.

3D structure databases

ProteinModelPortaliQ7A797.
SMRiQ7A797. Positions 3-801.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7A797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB41713; BAB41713; BAB41713.
PATRICi19573076. VBIStaAur116463_0508.

Phylogenomic databases

HOGENOMiHOG000218210.
OMAiYVGFNIQ.
OrthoDBiEOG65F8SM.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-517-MONOMER.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiCLPC_STAAN
AccessioniPrimary (citable) accession number: Q7A797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.