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Q7A777

- GCH4_STAAN

UniProt

Q7A777 - GCH4_STAAN

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei176 – 1761May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-558-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:SA0524
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292GTP cyclohydrolase FolE2PRO_0000147726Add
BLAST

Proteomic databases

PRIDEiQ7A777.

2D gel databases

SWISS-2DPAGEQ7A777.

Interactioni

Protein-protein interaction databases

STRINGi158879.SA0524.

Structurei

3D structure databases

ProteinModelPortaliQ7A777.
SMRiQ7A777. Positions 47-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7A777-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEFDLSTRE GRWKHFGSVD PIEGTKPTTK NEMTDLQSTH KDFLFEIEEV
60 70 80 90 100
GIKNLVYPVL VDQYQTAGTF SFSTSLTKDE KGINMSRIIE SVEKHYDNGI
110 120 130 140 150
ELEFNTLYQV LRTLQTNMKQ NAAGVDVSGK WFFDRYSPTT NIKAVGNADV
160 170 180 190 200
TYGLAIDGDK VTRKELTIEA TVTTLCPCSK EISEYSAHNQ RGVVTVKTYI
210 220 230 240 250
NKDQNIVDDY KNKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE
260 270 280 290
DLIRLIAADL VEFDWLDGFD IECRNEESIH QHDAFAKLKY RK
Length:292
Mass (Da):33,481
Last modified:July 5, 2004 - v1
Checksum:i78EAF10A9A42553B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41755.1.
PIRiH89824.
RefSeqiNP_373777.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41755; BAB41755; BAB41755.
GeneIDi1123329.
KEGGisau:SA0524.
PATRICi19573160. VBIStaAur116463_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41755.1 .
PIRi H89824.
RefSeqi NP_373777.1. NC_002745.2.

3D structure databases

ProteinModelPortali Q7A777.
SMRi Q7A777. Positions 47-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158879.SA0524.

2D gel databases

SWISS-2DPAGE Q7A777.

Proteomic databases

PRIDEi Q7A777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB41755 ; BAB41755 ; BAB41755 .
GeneIDi 1123329.
KEGGi sau:SA0524.
PATRICi 19573160. VBIStaAur116463_0550.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SAUR158879:GJCB-558-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.

Entry informationi

Entry nameiGCH4_STAAN
AccessioniPrimary (citable) accession number: Q7A777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3