Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7A774

- HPS_STAAN

UniProt

Q7A774 - HPS_STAAN

Protein

3-hexulose-6-phosphate synthase

Gene

SA0528

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate.By similarity

    Catalytic activityi

    D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.

    Pathwayi

    GO - Molecular functioni

    1. hexulose-6-phosphate synthase activity Source: InterPro
    2. orotidine-5'-phosphate decarboxylase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. carbohydrate metabolic process Source: UniProtKB-KW
    3. formaldehyde assimilation via ribulose monophosphate cycle Source: UniProtKB-UniPathway
    4. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbohydrate metabolism, One-carbon metabolism

    Enzyme and pathway databases

    BioCyciSAUR158879:GJCB-562-MONOMER.
    UniPathwayiUPA00294; UER00434.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hexulose-6-phosphate synthase (EC:4.1.2.43)
    Short name:
    HPS
    Alternative name(s):
    D-arabino-3-hexulose-6-phosphate formaldehyde lyase
    Gene namesi
    Ordered Locus Names:SA0528
    OrganismiStaphylococcus aureus (strain N315)
    Taxonomic identifieri158879 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000751: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2102103-hexulose-6-phosphate synthasePRO_0000269520Add
    BLAST

    2D gel databases

    SWISS-2DPAGEQ7A774.

    Interactioni

    Protein-protein interaction databases

    STRINGi158879.SA0528.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7A774.
    SMRiQ7A774. Positions 1-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HPS/KGPDC family. HPS subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0269.
    HOGENOMiHOG000226072.
    KOiK08093.
    OMAiYIDVVEI.
    OrthoDBiEOG66B435.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR017553. 3-hexulose-6-phosphate_synth.
    IPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR03128. RuMP_HxlA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7A774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELQLAIDLL NKEDAAELAN KVKDYVDIVE IGTPIIYNEG LPAVKHMADN    50
    ISNVKVLADM KIMDAADYEV SQAIKFGADV ITILGVAEDA SIKAAIEEAH 100
    KNNKQLLVDM IAVQDLEKRA KELDEMGADY IAVHTGYDLQ AEGQSPLESL 150
    RTVKSVIKNS KVAVAGGIKP DTIKDIVAES PDLVIVGGGI ANADDPVEAA 200
    KQCRAAIEGK 210
    Length:210
    Mass (Da):22,436
    Last modified:July 5, 2004 - v1
    Checksum:i7C952A812A729538
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB41759.1.
    PIRiD89825.
    RefSeqiNP_373781.1. NC_002745.2.

    Genome annotation databases

    EnsemblBacteriaiBAB41759; BAB41759; BAB41759.
    GeneIDi1123333.
    KEGGisau:SA0528.
    PATRICi19573168. VBIStaAur116463_0554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000018 Genomic DNA. Translation: BAB41759.1 .
    PIRi D89825.
    RefSeqi NP_373781.1. NC_002745.2.

    3D structure databases

    ProteinModelPortali Q7A774.
    SMRi Q7A774. Positions 1-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158879.SA0528.

    2D gel databases

    SWISS-2DPAGE Q7A774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB41759 ; BAB41759 ; BAB41759 .
    GeneIDi 1123333.
    KEGGi sau:SA0528.
    PATRICi 19573168. VBIStaAur116463_0554.

    Phylogenomic databases

    eggNOGi COG0269.
    HOGENOMi HOG000226072.
    KOi K08093.
    OMAi YIDVVEI.
    OrthoDBi EOG66B435.

    Enzyme and pathway databases

    UniPathwayi UPA00294 ; UER00434 .
    BioCyci SAUR158879:GJCB-562-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR017553. 3-hexulose-6-phosphate_synth.
    IPR013785. Aldolase_TIM.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR03128. RuMP_HxlA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: N315.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: N315.
    3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
      Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
      Submitted (OCT-2007) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: N315.

    Entry informationi

    Entry nameiHPS_STAAN
    AccessioniPrimary (citable) accession number: Q7A774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3