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Q7A774 (HPS_STAAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hexulose-6-phosphate synthase
Short name=HPS
EC=4.1.2.43
Alternative name(s):
D-arabino-3-hexulose-6-phosphate formaldehyde lyase
Gene names
Ordered Locus Names:SA0528
OrganismStaphylococcus aureus (strain N315) [Complete proteome] [HAMAP]
Taxonomic identifier158879 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate By similarity.

Catalytic activity

D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.

Pathway

One-carbon metabolism; formaldehyde assimilation via RuMP pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 1/2.

Sequence similarities

Belongs to the HPS/KGPDC family. HPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2102103-hexulose-6-phosphate synthase
PRO_0000269520

Sequences

Sequence LengthMass (Da)Tools
Q7A774 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7C952A812A729538

FASTA21022,436
        10         20         30         40         50         60 
MELQLAIDLL NKEDAAELAN KVKDYVDIVE IGTPIIYNEG LPAVKHMADN ISNVKVLADM 

        70         80         90        100        110        120 
KIMDAADYEV SQAIKFGADV ITILGVAEDA SIKAAIEEAH KNNKQLLVDM IAVQDLEKRA 

       130        140        150        160        170        180 
KELDEMGADY IAVHTGYDLQ AEGQSPLESL RTVKSVIKNS KVAVAGGIKP DTIKDIVAES 

       190        200        210 
PDLVIVGGGI ANADDPVEAA KQCRAAIEGK

« Hide

References

« Hide 'large scale' references
[1]"Whole genome sequencing of meticillin-resistant Staphylococcus aureus."
Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. expand/collapse author list , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K.
Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: N315.
[2]"Correlation of proteomic and transcriptomic profiles of Staphylococcus aureus during the post-exponential phase of growth."
Scherl A., Francois P., Bento M., Deshusses J.M., Charbonnier Y., Converset V., Huyghe A., Walter N., Hoogland C., Appel R.D., Sanchez J.-C., Zimmermann-Ivol C.G., Corthals G.L., Hochstrasser D.F., Schrenzel J.
J. Microbiol. Methods 60:247-257(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
Strain: N315.
[3]"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
Submitted (OCT-2007) to UniProtKB
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: N315.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000018 Genomic DNA. Translation: BAB41759.1.
PIRD89825.
RefSeqNP_373781.1. NC_002745.2.

3D structure databases

ProteinModelPortalQ7A774.
SMRQ7A774. Positions 1-202.
ModBaseSearch...

Protein-protein interaction databases

STRING158879.SA0528.

2D gel databases

SWISS-2DPAGEQ7A774.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB41759; BAB41759; BAB41759.
GeneID1123333.
KEGGsau:SA0528.
PATRIC19573168. VBIStaAur116463_0554.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0269.
HOGENOMHOG000226072.
KOK08093.
OMAYIDVVEI.
ProtClustDBCLSK884731.

Enzyme and pathway databases

BioCycSAUR158879:GJCB-562-MONOMER.
UniPathwayUPA00294; UER00434.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR017553. 3-hexulose-6-phosphate_synth.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR03128. RuMP_HxlA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPS_STAAN
AccessionPrimary (citable) accession number: Q7A774
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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