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Protein

3-hexulose-6-phosphate synthase

Gene

SA0528

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate.By similarity

Catalytic activityi

D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbohydrate metabolism, One-carbon metabolism

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-562-MONOMER.
UniPathwayiUPA00294; UER00434.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hexulose-6-phosphate synthase (EC:4.1.2.43)
Short name:
HPS
Alternative name(s):
D-arabino-3-hexulose-6-phosphate formaldehyde lyase
Gene namesi
Ordered Locus Names:SA0528
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2102103-hexulose-6-phosphate synthasePRO_0000269520Add
BLAST

2D gel databases

SWISS-2DPAGEQ7A774.

Interactioni

Protein-protein interaction databases

STRINGi158879.SA0528.

Structurei

3D structure databases

ProteinModelPortaliQ7A774.
SMRiQ7A774. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPS/KGPDC family. HPS subfamily.Curated

Phylogenomic databases

eggNOGiCOG0269.
HOGENOMiHOG000226072.
KOiK08093.
OMAiFADMKTM.
OrthoDBiEOG66B435.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR017553. 3-hexulose-6-phosphate_synth.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR03128. RuMP_HxlA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7A774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQLAIDLL NKEDAAELAN KVKDYVDIVE IGTPIIYNEG LPAVKHMADN
60 70 80 90 100
ISNVKVLADM KIMDAADYEV SQAIKFGADV ITILGVAEDA SIKAAIEEAH
110 120 130 140 150
KNNKQLLVDM IAVQDLEKRA KELDEMGADY IAVHTGYDLQ AEGQSPLESL
160 170 180 190 200
RTVKSVIKNS KVAVAGGIKP DTIKDIVAES PDLVIVGGGI ANADDPVEAA
210
KQCRAAIEGK
Length:210
Mass (Da):22,436
Last modified:July 5, 2004 - v1
Checksum:i7C952A812A729538
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41759.1.
PIRiD89825.
RefSeqiNP_373781.1. NC_002745.2.
WP_000422861.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB41759; BAB41759; BAB41759.
GeneIDi23196442.
KEGGisau:SA0528.
PATRICi19573168. VBIStaAur116463_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB41759.1.
PIRiD89825.
RefSeqiNP_373781.1. NC_002745.2.
WP_000422861.1. NC_002745.2.

3D structure databases

ProteinModelPortaliQ7A774.
SMRiQ7A774. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158879.SA0528.

2D gel databases

SWISS-2DPAGEQ7A774.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB41759; BAB41759; BAB41759.
GeneIDi23196442.
KEGGisau:SA0528.
PATRICi19573168. VBIStaAur116463_0554.

Phylogenomic databases

eggNOGiCOG0269.
HOGENOMiHOG000226072.
KOiK08093.
OMAiFADMKTM.
OrthoDBiEOG66B435.

Enzyme and pathway databases

UniPathwayiUPA00294; UER00434.
BioCyciSAUR158879:GJCB-562-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR017553. 3-hexulose-6-phosphate_synth.
IPR013785. Aldolase_TIM.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR03128. RuMP_HxlA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: N315.
  3. "Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315."
    Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.
    Submitted (OCT-2007) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: N315.

Entry informationi

Entry nameiHPS_STAAN
AccessioniPrimary (citable) accession number: Q7A774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.